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Artikel Jurnal
Exploring the therapeutic potential of baicalin against MCF-7 breast cancer cells: biochemical, in vitro, and computational perspectives
BackgroundBaicalin (BA), a flavonoid extracted from the dried roots of Scutellaria baicalensis, is well known in traditional Chinese medicine (TCM) for its anti-apoptotic, anti-inflammatory, and antioxidant activities. However, its therapeutic potential in breast cancer needs to be evaluated…
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Artikel Jurnal
Combined azelastine fluticasone nasal spray versus fluticasone propionate nasal spray in postoperative management of central compartment atopic disease (CCAD)
BackgroundCentral compartment atopic disease (CCAD) is a subtype of chronic rhinosinusitis with nasal polyps (CRSwNP), distinguished by polypoid changes in the middle turbinates, superior nasal septum, and/or superior turbinates.ObjectiveThe aim of this study was to compare the efficacy of combined…
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Artikel Jurnal
Therapeutic potential of combination medicinal mushrooms (NevG) in ischemic stroke: correlating motor function, cognitive recovery, and hippocampal integrity in MCAO rats
BackgroundIschemic stroke is a major neurological disorder that is characterized by cognitive decline and sensorimotor impairment. Despite the potential of therapeutic effects and anti-inflammatory properties of medicinal mushrooms, most current research focuses on single-species effects rather…
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Artikel Jurnal
7-Dehydrocholesterol attenuates osteoarthritis by synergistically inhibiting oxidative stress, inflammation, and ferroptosis in macrophages
ObjectiveOsteoarthritis (OA) is a prevalent degenerative disorder affecting joints, characterized by progressive cartilage deterioration, inflammation of the synovium, and structural damage to subchondral bone. Inflammation mediated by synovial macrophages is a key driver of OA progression…
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Artikel Jurnal
Exploratory analysis of the association between body composition albumin-bound paclitaxel induced peripheral neuropathy
ObjectiveThis study aimed to examine the relationship between L3 Skeletal Muscle Index (L3SMI) and the incidence and severity of chemotherapy-induced peripheral neuropathy (CIPN) in patients with malignant tumors treated with nab-PTX (albumin-bound paclitaxel) monotherapy or in combination with…
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Artikel Jurnal
Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury
IntroductionThe combination of ginsenoside Rg1 and salidroside (PRC) exhibits cardioprotective potential against myocardial ischemia-reperfusion injury (MIRI), yet its underlying mechanism remains unclear.Materials and MethodsAn in vivo rat model of MIRI and an in vitro H/R model using H9c2…
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Artikel Jurnal
Heart failure induced by cancer therapies: focus on targeted agents, mechanisms, risk prediction, and clinical management
Targeted therapies have revolutionized oncology but are accompanied by significant cardiovascular complications, with heart failure being a major dose-limiting toxicity. This review primarily focuses on heart failure induced by targeted anticancer agents, while also contextualizing findings with…
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Artikel Jurnal
Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks
ContextDanggui Niantong granules (DGNTG), a traditional Chinese medicine, serve as an effective therapeutic agent for the treatment of rheumatoid arthritis (RA). However, the comprehensive molecular mechanisms of DGNTG in RA remain unclear. Increasing evidence highlights the significant role of…
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Artikel Jurnal
CYP2C19 genotype-guided escalation to ticagrelor vs. clopidogrel in secondary stroke prevention: a retrospective cohort study
ObjectiveTo evaluate the effectiveness and safety of an antiplatelet therapy strategy guided by CYP2C19 genotyping in the secondary prevention of ischemic stroke in a real-world setting.MethodsThis single-center retrospective cohort study enrolled 623 ischemic stroke patients. Based on their…
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Artikel Jurnal
Differential cardiovascular benefits of SGLT2 inhibitors, sacubitril/valsartan, omecamtiv mecarbil, and vericiguat across heart failure phenotypes: a systematic review and meta-analysis
AimThe study evaluated the cardiovascular outcomes associated with pharmacological treatments in heart failure (HF) patients and explored whether the benefits/risks associated with these drugs for HF with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) were consistent with HF with…
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Artikel Jurnal Teks lengkap
Atrial fibrillation signals associated with overactive bladder drugs across JADER and FAERS: disproportionality and time-to-onset analyses
IntroductionOveractive bladder (OAB) drugs are widely prescribed, yet the occurrence of atrial fibrillation (AF) after treatment initiation remains poorly characterized.MethodsWe evaluated reports of AF associated with OAB medications using two spontaneous reporting systems (SRSs): the Japanese…
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Artikel Jurnal
Efficacy and safety of Nefecon, glucocorticoids, or supportive therapyadded to RASi+SGLT2i in IgA nephropathy
BackgroundIgAN is the most common primary glomerulonephritis worldwide. Currently, “RASi + SGLT2i” has become the standard basic treatment regimen. Nefecon is an oral budesonide formulation targeting the intestinal mucosa.MethodsA single-center retrospective cohort study was conducted, including…
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Artikel Jurnal
A multicenter, randomized, double-blind, double-simulated, positive drug parallel-controlled clinical trial to evaluate the efficacy and safety of Xiao’er Fengreqing oral liquid in the treatment of acute pharyngitis/tonsillitis in children
BackgroundAcute pharyngitis and tonsillitis are common in children. Xiao’er Fengreqing Oral Liquid (XFQOL) shows potential benefits in previous studies of pediatric acute upper respiratory tract infections and influenza, but high-quality clinical evidence for pediatric acute pharyngitis/tonsillitis…
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Artikel Jurnal
Fucoxanthin attenuates carbonyl stress and neuroinflammation by modulating MGO/RAGE/NF-κB axis in Aβ-induced models
IntroductionAmyloid-β (Aβ) accumulation is a central pathological feature of Alzheimer’s disease (AD) and a major driver of disease progression. Recent evidence suggests that carbonyl stress associated with Aβ plays a critical role in AD pathology by promoting neuroinflammation and neuronal damage…
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Artikel Jurnal
Sertraline safety in adolescents experiencing a depressive episode during first 3 weeks: added anxiolytic matters more than CYP2C19 polymorphisms
ObjectivesTo evaluate the associations of clinical and pharmacogenetic factors (CYP2C19*2, *17 polymorphisms) with the safety parameters of sertraline in adolescents with a depressive episode and suicidal intentions for 3 weeks in a psychiatric hospital.MethodsThe study included 112 adolescents…
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Artikel Jurnal
Pharmacokinetics and nephrotoxicity of cisplatin modulated by combination therapy with brusatol
Ethnopharmacological RelevanceQuassinoid brusatol, isolated from the traditional Chinese medicine Brucea javanica (L.) Merr., significantly increases the intracellular concentration of cisplatin and reduces tumor size by inhibiting the Nrf2 pathway. However, the underlying mechanism remains…
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Artikel Jurnal
Physician attitudes toward natural syrup formulations for cough and sore throat: a multinational cross-sectional survey of 398 healthcare professionals across 13 countries
BackgroundUnderstanding physician attitudes toward natural over the counter (OTC) products in respiratory medicine remains understudied in multinational contexts. This study represents the first multinational survey of physician perceptions regarding natural syrup formulations for cough and sore…
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Artikel Jurnal
Hydroxychloroquine withdrawal triggers pregnancy-associated pulmonary arterial hypertension in systemic lupus erythematosus: a case report and exploration of the Complement-EndMT axis
BackgroundThe continuation of hydroxychloroquine (HCQ) during pregnancy in patients with systemic lupus erythematosus (SLE) is a cornerstone of management, proven to mitigate maternal disease flares. However, its precise role in preventing the devastating cardiopulmonary complication of…
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