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Journal Article
Oleanolic acid and its derivatives in breast cancer therapy: mechanistic insights, structural modifications, and novel delivery strategies
Oleanolic acid is a natural pentacyclic triterpenoid widely found in dietary plants and has attracted translational interest in breast cancer research. This review addresses how oleanolic acid and its derivatives exert anticancer effects in breast cancer models, and how structural modification and…
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Journal Article
Evaluation of potential of Revstone® on gentamicin-induced renal toxicity in Wistar rats: a comparative study of the capsule and syrup forms
IntroductionRevstone®, a polyherbal formulation available in capsule and syrup forms, is designed to treat kidney-related disorders. However, its renoprotective efficacy remains insufficiently validated. In this study, we aimed to evaluate and compare the renoprotective potential of Revstone®…
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Journal Article
Bioequivalence study of testosterone undecanoate soft capsules in healthy postmenopausal women under fed conditions: a single-center, four-period, repeated crossover trial
PurposeThis study aimed to systematically evaluate the pharmacokinetics, bioequivalence, and safety of a single postprandial oral dose of testosterone undecanoate (TU) and its originator drug Andriol Testocaps® in healthy postmenopausal Chinese women, providing theoretical support for optimizing…
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Journal Article
Induction of apoptosis by ethanol extract of sapodilla leaf in HGT-1 cells involved caspase-independent signal transduction pathway and activation of Nrf2/HO-1
Gastric cancer has become one of the most common cancers globally. Sapodilla or known as Manilkara zapota (L.) P. Royen, has been traditionally applied for cough, cold, and diarrhea. The detailed mechanisms in modulating sapodilla leaf 70% ethanol extract against HGT-1 human gastric cancer cell…
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Journal Article
Curcumin in oral health: mechanisms, clinical evidence, and delivery strategies
Curcumin, a polyphenolic compound derived from the turmeric rhizome (Curcuma longa), has attracted significant interest in dentistry and oral medicine because of its multifaceted therapeutic properties. In particular, curcumin exhibits potent anti-inflammatory, antioxidant, and antimicrobial…
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Journal Article
Celastrol increases anoikis sensitivity to suppress triple-negative breast cancer via EGFR pathway and p-EMT state regulation
Faced with the highly malignant threat of metastatic triple-negative breast cancer (TNBC), the effect of traditional chemical agents is limited, and new anti-metastasis drug remains to be explored. Celastrol (Cel) is a bioactive compound derived from Tripterygium wilfordii with significant…
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Journal Article
Relevance and limitations of clinical follow-up in a pharmacokinetic study on direct oral anticoagulants
IntroductionDirect oral anticoagulants (DOACs), including apixaban and rivaroxaban, are widely prescribed for the prevention of cardioembolic stroke and the treatment of venous thromboembolism. Although routine therapeutic monitoring is not required, real-world patients often present with multiple…
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Journal Article
Pharmacological mechanism of active components in Polygonatum odoratum for idiopathic pulmonary fibrosis: a study integrating bioinformatics and experimental validation
Introduction: Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, and often fatal interstitial lung disease characterized by persistent alveolar injury, inflammation, and extracellular matrix remodeling, ultimately leading to respiratory failure. Despite ongoing research, current…
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Journal Article
Application of the miRNAs as biomarkers and therapeutic strategies in periodontal inflammation
Inflammatory and host immunological responses to bacterial tooth infections contribute to the development of periodontal disease. MiRNAs (miRNAs) play a critical role in regulating these immunological and inflammatory responses. miRNAs influence both innate and adaptive immunity in periodontal…
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Journal Article
Beyond codeine – the evidence landscape of conventional, natural, and emerging antitussive therapies: a systematic review and meta-analysis
BackgroundFor decades, cough treatment has relied on centrally acting agents like codeine despite inconsistent efficacy. Advances in cough neurobiology enabled targeted therapies. Natural remedies remain widely used, though evidence for their effectiveness and safety is limited. This study aimed to…
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Journal Article
Prevalence of actionable pharmacogenomic variants in Brazilian patients with cancer
IntroductionPharmacogenomic (PGx) variants can influence drug efficacy and safety, yet their prevalence in Latin American populations with cancer is underexplored. Our aim is to characterize the frequency and phenotypic distribution of actionable pharmacogenes in Brazilian patients with metastatic…
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Journal Article
Finerenone is associated with pronounced uric acid reduction in hyperuricemic diabetic kidney disease: a real-world analysis
BackgroundDiabetic kidney disease (DKD) is a critical complication of type 2 diabetes, often compounded by hyperuricemia, which may accelerate renal function decline. While finerenone, a nonsteroidal mineralocorticoid receptor antagonist (MRA), provides renal and cardiovascular benefits, its impact…
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Journal Article
Network toxicology and single-cell analysis reveal key gene-mediated bisphenol a interference with granulosa cell function in polycystic ovary syndrome
BackgroundBisphenol A (BPA), a typical endocrine-disrupting chemical, is implicated in the pathogenesis of Polycystic Ovary Syndrome (PCOS); however, the underlying molecular mechanisms and pathophysiological processes remain unclear. This study aims to decipher molecular interactions between BPA…
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Journal Article
Cistanche tubulosa-Ginkgo biloba combination enhances memory via cortico-cerebellar reorganization: a randomized controlled trial
BackgroundAge-related memory decline has emerged as a critical global public health challenge, yet few ethnopharmacological interventions have demonstrated robust clinical efficacy in improving memory and cognitive function.ObjectivesThis randomized, double-blind, placebo-controlled trial aimed to…
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Journal Article
Antifungal and anti-virulence activities of cinnamon, thyme, and clove essential oils against Candida species
BackgroundCandida species are major opportunistic pathogens, with Candida albicans being the most frequent cause of candidiasis. However, increasing rates of non-albicans infections and antifungal resistance bring an urgent need for new therapeutics. Essential oils (EOs) have gained attention due…
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Journal Article
Research article proteomics-based plasma biomarkers for predicting CRKP infection in ICU sepsis patients
BackgroundEarly differentiation between carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-sensitive K. pneumoniae (CSKP) infections is critical due to limited treatment options and high mortality associated with CRKP. Current diagnostic methods are slow and insufficient for timely…
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Journal Article
Lycium barbarum polysaccharides as prebiotics prevent colorectal cancer liver metastasis in non-alcoholic fatty liver disease by modulating gut microbiota–FGF21-PI3K-AKT axis
IntroductionColorectal cancer liver metastasis (CRLM) is the leading cause of death in colorectal cancer, and nonalcoholic fatty liver disease (NAFLD) promotes CRLM. Lycium barbarum polysaccharides (LBPs), bioactive metabolites of the traditional medicinal plant Lycium barbarum L, inhibit the…
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Journal Article
Will the introduction of β-lactamase inhibitors alter the adverse event profile of parent penicillins antibiotics? a pharmacovigilance study based on amoxicillin-clavulanate and ampicillin-sulbactam
ObjectiveThis study aimed to investigate whether the introduction of β-lactamase inhibitors (BLIs) alters the adverse event (AE) profiles of parent penicillin antibiotics, using real-world pharmacovigilance data.MethodsA disproportionality analysis was conducted using reports from the FDA Adverse…
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