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Journal Article
Applicability of academic real-world data research in the case studies of the HTx project to practical health technology assessment work
IntroductionNext-Generation HTA (HTx) is a recently finalised EU project which aimed to connect academic HTA researchers with HTA practitioners.MethodsThis paper studies the applicability of the academic RWD research conducted through four case studies within the HTx project to practical HTA work…
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Journal Article
Real-world pharmacovigilance and molecular mechanisms of fruquintinib: SRC and STAT3 as potential off-target mediators of proteinuria
BackgroundFruquintinib, a highly selective inhibitor of vascular endothelial growth factor receptors (VEGFR) 1–3, has demonstrated significant survival benefits in metastatic colorectal cancer (mCRC). While pivotal clinical trials have characterized its general toxicity profile, the molecular…
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Journal Article
Xiao Chai Hu Tang-derived decoction (Tung-Yi Fang) suppresses triple negative breast cancer cells in vitro and in vivo via regulating EGFR/AXL-mediated signaling
BackgroundTriple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options. Xiao Chai Hu Tang (XCHT), a classical herbal formula, is prescribed as an adjuvant therapy in breast cancer care. However, the high sugar content of XCHT may influence its…
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Journal Article
Neuroprotective effects of curcumin, memantine, and caffeic acid in a Rat model of cerebral ischemia-reperfusion injury
Cerebral ischemia–reperfusion (I/R) injury leads to neuronal loss through oxidative stress, inflammation, and apoptosis. Curcumin, memantine, and caffeic acid possess antioxidant and neuroprotective properties. This study compared their efficacy in a rat model of transient cerebral ischemia. Forty…
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Journal Article
Traditional Chinese medicine and plant metabolites for rheumatoid arthritis via modulating gut microbiota: a scoping review evaluating the transition from correlation to causality
BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis. The “gut-joint axis” proposes gut microbiota and metabolites modulate RA inflammation via mucosal and systemic immune responses. Botanical drugs (Traditional Chinese Medicine, TCM) and plant metabolites…
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Journal Article
Selective phosphoinositide 3-kinase inhibitors and implication in diabetic retinopathy as pharmacological tools
Phosphoinositide 3-kinases (PI3Ks) are ubiquitous enzymes, that regulate different cellular functions, most involved in pathogenesis and progression of several oncological diseases. Indeed, some PI3K inhibitors have been approved for blood cancers, such as lymphoma. Interestingly, leniolisib, a…
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Journal Article
Bridging evidence worlds: policy and practice pathways for integrating clinical trials and real-world data in drug development and HTA
The integration of clinical and real-world evidence represents one of the most critical transformations in modern drug development and health technology assessment (HTA). Despite increasing regulatory openness, however, clinical trial evidence and real-world data (RWD) still operate largely as…
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Journal Article
Hydroxysafflor yellow A attenuates sepsis-induced intestinal barrier dysfunction by modulating Bcl-2/SOD2-mediated mitochondrial apoptosis
BackgroundSepsis remains a major cause of hospital mortality. Sepsis-induced intestinal injury is regarded as the driving force behind the rapid progression of critical conditions such as shock and sepsis, and serves as the initiating factor of subsequent organ dysfunction. Therefore, the…
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Journal Article
Retrospective study on the effectiveness of clinical pharmacists’ consultation in the management of carbapenem-resistant organisms infections
BackgroundThe emergence and global dissemination of carbapenem-resistant organisms (CROs) pose a significant public health threat. Clinical pharmacists play a pivotal role in optimizing antimicrobial therapy through their expertise in pharmacokinetics, pharmacodynamics, and antimicrobial…
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Journal Article
Reduced-order modeling of solute transport within physiologically realistic solid tumor microenvironment
IntroductionSolid tumors are characterized by densely packed extracellular matrices and limited vascularization, creating significant resistance to both diffusive and convective transport. Tumor growth depends on complex flow–structure interactions across multiple scales, while vascular…
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Journal Article
Rus-GXF, a ruscogenin glycoside, binds to the ADP-binding domain of JAK1 to prevent inflammation and barrier damage in acute lung injury
BackgroundRuscogenin-1-O-[β-D-glucopyranosyl (1→2)][β-D-xylopyranosyl (1→3)] -β-D-fucopyranoside (Rus-GXF) is a ruscogenin glycoside of Liriope muscari (Decaisne) L. H. Bailey, yet its protective effects against acute lung injury—a condition characterized by exacerbated inflammation and barrier…
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Journal Article
Hydrochlorothiazide and chlorthalidone use and glaucoma risk: pharmacovigilance analysis and nationwide cohort study
Hydrochlorothiazide and chlorthalidone are widely used thiazide diuretics, and pharmacovigilance reports have suggested a possible link between their use and glaucoma. Therefore, this study aims to evaluate whether the use of hydrochlorothiazide or chlorthalidone is associated with an increased…
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Journal Article
Shen-yuan-dan capsule inhibits METTL3-mediated m6A methylation to restore autophagy homeostasis and attenuate post-myocardial infarction heart failure
BackgroundHeart failure (HF) after myocardial infarction (MI) is a serious health issue. This study investigates the therapeutic effects of Shen-Yuan-Dan Capsule (SYD) on post-MI HF and explores its mechanisms, particularly involving m6A modification and autophagy.MethodsNetwork pharmacology and…
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Journal Article
Ethnopharmacology and ecosystem applications of woody plant species in the Southern European Alps: a systematic review
IntroductionAlpine woody plants are deeply embedded in traditional healthcare systems across the Southern European Alps, where multiple organs—including leaves, bark, fruits, buds, and flowers—are used to manage respiratory, musculoskeletal, gastrointestinal, dermatological, metabolic…
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Journal Article
Multi-target computational pipeline for discovery of pan-influenza neuraminidase inhibitors
The continuous evolution of influenza A and B viruses, coupled with the emergence of drug resistance, creates a pressing need for novel antiviral agents with broad-spectrum activity. The viral neuraminidase enzyme remains a prime target, but its structural variability across different strains…
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Journal Article
Comparative pharmacovigilance of non-benzodiazepine receptor agonists versus dual orexin receptor antagonists for insomnia in older adults
BackgroundThe accelerating global aging trend has positioned insomnia in the elderly as a major public health challenge. Although cognitive behavioral therapy is the first-line intervention, pharmacological treatment remains widely used. However, significant safety concerns exist regarding the use…
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Journal Article
Ferroptosis in diabetes-associated cognitive dysfunction: mechanisms and therapeutic potential
Diabetic-Associated Cognitive Dysfunction (DACD) is a major central nervous system complication of diabetes. Its pathogenesis involves dysfunction of the neurovascular unit, oxidative stress, and chronic neuroinflammation. Ferroptosis, an iron-dependent form of regulated cell death, is strongly…
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