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Frontiers in Pharmacology
Scopus
ISSN 1663-9812 · Frontiers Media S.A. · 31,912 articles in the index
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Journal Article
PDE1B and PDE10A as novel targets for schizophrenia: from molecular design and synthesis to therapeutic promise
Phosphodiesterase 1B (PDE1B) and phosphodiesterase 10A (PDE10A), members of the phosphodiesterase superfamily, are responsible for cyclic nucleotide hydrolysis, thereby regulating key intracellular signaling pathways such as cAMP response element-binding protein (CREB) activation and brain-derived…
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Journal Article
Thymelaea hirsuta (L.) Endl. extract attenuates NLRP3 inflammasome activation via modulation of ATPase activity
BackgroundThe NLRP3 inflammasome is a multiprotein complex of the innate immune system that mediates the maturation and secretion of interleukin-1β (IL-1β) and plays a pivotal role in the pathogenesis of chronic inflammatory diseases, including asthma, metabolic disorders, and autoimmune diseases…
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Journal Article
Intra-tumoural microenvironment and bugs-based drug design: foreseeable future in oncology and immuno-oncology
The term tumour microenvironment (TME) encompasses the coexistence of microorganisms and different cellular elements including endothelial cells, macrophages, cancer-associated fibroblasts and a complex network of microvessels. Integration of tumour immunity and intratumoural microbiome into…
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Journal Article
NAPQI adducts in patients with selective hypersensitivity to acetaminophen
IntroductionAcetaminophen, a widely used analgesic and antipyretic, can cause adverse reactions ranging from mild urticaria to severe anaphylaxis. While interindividual differences in pharmacokinetics and genetic polymorphisms are known to affect acetaminophen metabolism, the specific mechanisms…
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Journal Article
Recent advances in mitochondria-targeted porphyrin-based metal-organic frameworks for enhanced cancer therapy
Porphyrin-based metal-organic frameworks (MOFs) offer exceptional advantages for cancer therapy, including high photosensitizer loading, tunable nanostructures, and suppression of porphyrin self-quenching. By functionalizing with mitochondria targeting ligands, these platforms deliver reactive…
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Journal Article
Case Report: Severe SIADH and QTc prolongation induced by escitalopram-quetiapine interaction in a CYP2C19 intermediate metabolizer at therapeutic doses
Escitalopram is widely regarded as a well-tolerated selective serotonin reuptake inhibitor (SSRI) with a favorable safety profile. However, severe adverse events can occur even at therapeutic doses in susceptible individuals. Here, we report a rare case of simultaneous life-threatening Syndrome of…
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Journal Article
RP-182 alleviated obstruction-induced renal fibrosis by reprogramming CD206+ macrophages
IntroductionObstructive nephropathy is a major cause of chronic kidney disease (CKD), characterized by progressive renal fibrosis with limited treatment options. CD206+ macrophages have emerged as key drivers of fibrogenesis, yet targeted strategies against this subset remain…
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Journal Article
Cannabis sativa L. roots extract modulates gastrointestinal motility and ameliorates ethanol-induced gastric ulcers in animal models
IntroductionCannabis sativa L. roots are traditionally used to manage gastrointestinal (GI) disorders; however, experimental pharmacological evidence supporting these uses remains limited. This study investigated the chemical profile, safety, and GI-related pharmacological effects of an ethanolic…
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Journal Article
Efficacy and safety of cinobufacini capsules combined with oxaliplatin-based chemotherapy for advanced colorectal cancer: a human systematic review and meta-analysis
BackgroundPatients with stage III–IV colorectal cancer (CRC) face poor prognosis due to metastases and limited treatment options. In China, cinobufacini capsules are widely used as a complementary medicine, but evidence for their clinical value remains insufficient.MethodsSystematic searches were…
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Journal Article
Integrating network pharmacology and transcriptomics to reveal the therapeutic effect of Long Mu Ning Xin Decoction on attention-deficit/hyperactivity disorder by regulating cAMP and PI3K/AKT pathways
BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children. Long Mu Ning Xin Decoction (LMNXD) shows established clinical efficacy against ADHD, yet its mechanistic basis is not fully elucidated.ObjectiveThis study investigates the therapeutic…
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Journal Article
Tezepelumab in severe asthma: chest computed tomography assessment of airway remodeling and clinical remission
IntroductionSevere asthma is characterized by persistent uncontrolled symptoms despite optimal standard therapy and/or by the need for high-intensity treatment to maintain control. Thymic stromal lymphopoietin (TSLP) is a key innate cytokine that promotes bronchial inflammation in both T2-high and…
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Journal Article
Quercetin regulates autophagy and attenuates airway inflammation in a murine model of asthma: association with PI3K/Akt/mTOR signaling pathway modulation
BackgroundAs a natural flavonoid, quercetin has anti-inflammatory and anti-oxidative activities. Studies confirm its beneficial effect on asthma, but the underlying mechanism remains unclear. This study aimed to systematically evaluate quercetin’s efficacy in treating asthma, explore its regulatory…
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Journal Article
New pyrimidine derivatives as potential agents against hepatocellular carcinoma: design, synthesis, and in vitro and in vivo biological evaluations
BackgroundSorafenib is a tyrosine kinase inhibitor (TKI) used to treat hepatocellular carcinoma (HCC), but this drug causes clinically significant toxicities in approximately 50% of patients. Given the high frequency and severity of these side effects, it is necessary to develop new, safer drugs to…
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Journal Article
Ramulus mori (Sangzhi) alkaloids improve intestinal oxidative damage and inflammation in DHEA-induced polycystic ovary syndrome rats via gut microbiota and metabolite modulation
IntroductionIntestinal dysbiosis, characterized by reduced diversity and enrichment of pro-inflammatory taxa, is implicated in the pathogenesis of polycystic ovary syndrome (PCOS). Ramulus mori (Sangzhi) alkaloids (SZ-A), approved in China for type 2 diabetes with broad metabolic effects, remain…
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Journal Article
Spatial profiling of the metabolism-immune axis in ovarian cancer
Ovarian cancer remains a lethal disease marked by profound therapeutic resistance, largely orchestrated by a complex tumor microenvironment (TME) governed by metabolism-immune crosstalk. This review focuses on the spatiotemporal dynamics of the metabolism-immune axis in ovarian cancer progression…
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Journal Article
Case Report: Toxic epidermal necrolysis induced by sintilimab in a patient with advanced lung squamous cell carcinoma
BackgroundSintilimab is an effective PD-1 immune checkpoint inhibitor (ICI) for advanced non-small cell lung cancer (NSCLC). However, it can cause severe immune-related adverse events (irAEs) such as toxic epidermal necrolysis (TEN), a rare hypersensitivity reaction with significant mortality…
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