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Journal of Toxicology
Scopus
ISSN 1687-8191 · Wiley · 555 articles in the index
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Journal Article
Dexrazoxane Protects Against Hand–Foot Syndrome–Like Skin Damage in Pegylated Liposomal Doxorubicin-Treated Mice
The anticancer drug pegylated liposomal doxorubicin (PLD) can cause hand–foot syndrome (HFS), a condition that develops in the palms and soles when pressure is frequently applied. Strategies to address HFS are insufficient. Dexrazoxane (DXZ) protects against doxorubicin-induced cardiotoxicity…
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Journal Article
Toxicological Assessment of D-Allulose From a Novel One-Step Fermentation Process Using Genetically Modified Escherichia coli: A 90-Day Dietary Toxicity Study in Rats
D-Allulose is a rare monosaccharide structurally similar to D-fructose, characterized by low caloric content and relatively high sweetness. This study aimed to conduct a 90-day oral toxicity test to systemically evaluate the potential toxicological effects of D-allulose produced via a novel…
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Journal Article
Potential of Graphene Nanoparticles for Reducing Cadmium Toxicity and Environmental Contamination
This narrative review synthesizes peer-reviewed studies retrieved from major scientific databases addressing the environmental and biological applications of graphene-based nanomaterials for cadmium mitigation. Cadmium (Cd) is a nonessential and highly toxic heavy metal with a prolonged biological…
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Journal Article
Empagliflozin Alleviates Arsenic Trioxide–Induced Nephrotoxicity by Activating the SIRT1/Akt/Nrf2 Pathway
Arsenic trioxide (ATO), utilized in the treatment of acute promyelocytic leukemia (APL), presents significant renal toxicity that restricts its clinical usage. The potential effects of empagliflozin (EMPA) on ATO-induced nephrotoxicity remain unexplored. This study aims to investigate whether EMPA…
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Journal Article
Organ-Specific Microplastic Profiling and Polymer Characterization in Freshwater Fish Species of Karnataka
Microplastic (MP) contamination is an emerging threat to freshwater ecosystems and food security. The objective of this study was to provide a comprehensive baseline assessment of MP abundance, polymer composition, and tissue-specific distribution across five organs (gut, gills, liver, gonads, and…
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Journal Article
Combined Toxicity Effects and Health Risks of Microplastics and Multiple Pollutants
Microplastics, as emerging pollutants, are ubiquitously present globally and pose significant threats to both ecosystems and human health. These pollutants not only exert direct toxicity on the environment and living organisms but also influence the toxicity of other pollutants through mechanisms…
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Journal Article
In Vitro hRPTEC TERT1 Model for Uranium-Induced Nephrotoxicity Pathway Study
As a heavy metal and alpha emitter, uranium U(VI) presents chemical and radiological toxicity risks. Its toxicity particularly targets the kidneys in the event of intoxication, but the detailed study mechanisms leading to uranium-induced renal failure have not yet been studied based on the adverse…
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Journal Article
Spatiotemporal Distribution, Risk, and Source Identification of Organochlorine Pesticides in the Surface Water of Shitalakshya River, Bangladesh
This study investigates the spatiotemporal distribution of organochlorine pesticides (OCPs) in the surface water (n = 60) of Shitalakshya River, Bangladesh, by an optimized and validated LLE–GC–ECD method by calibration (0.10–5.00 µgL−1), linearity (R2 = 0.995–0.999), recovery (80.11%–117.10%)…
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Journal Article
Seasonal Variation of Microplastic Contamination in Landfill Leachate, River Water, and Soil During Premonsoon and Monsoon: First Evidence From Landfill Sites in Nepal
Landfills serve as a significant source of microplastics (MPs) contamination, affecting the surrounding air, water, and agricultural soils. This study examined the seasonal variation of MPs in leachate, river water, and soil at Sisdole (old) and Banchare Dada (new) landfill sites (LFSs). MPs…
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Journal Article
Toxicological Profile of a Quercus laurina Bark Extract Through Oral Administration: Impact on Hepatocyte Mitochondrial Bioenergetics
Quercus laurina is an oak species used orally in Mexican folk medicine. However, its toxicological profile has not yet been evaluated, which makes it difficult to determine safe doses for traditional preparations. This study, for the first time, evaluates the acute toxicity of an ethanolic extract…
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Journal Article
Adverse Effects of Airborne Heavy Metals on Human Skin Cells: Insights From Sebum Analysis of Indoor and Outdoor Workers
Heavy metals in particulate matter (PM) contribute to oxidative stress, DNA damage, and inflammatory responses in skin cells. This study aimed to investigate the toxic effects of airborne heavy metals on human sebocytes, keratinocytes, and ex vivo skin. To this end, we collected sebum samples from…
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Journal Article
Subacute Oral Toxicity Evaluation of Red Pine Oil in Sprague–Dawley Rats: Safety Profiling for Potential Therapeutic Use
Red pine oil (Pinus densiflora) is a monoterpene-rich essential oil with antimicrobial, antioxidant, and anti-inflammatory activities. While commonly used topically, its systemic safety following oral use remains underexplored, limiting its development as an oral therapeutic or supplement. This…
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Journal Article
Resveratrol Partially Attenuates Lung Responses to Diesel Exhaust in Aged Mice
Despite scientific evidence and government actions aimed at reducing air pollution, it remains a major public health issue in large urban centers, compromising human health, particularly among the most vulnerable populations, including the elderly. Polyphenolic compounds are believed to have…