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Stem Cells International
Scopus
ISSN 1687-966X · Wiley · 3,085 articles in the index
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Journal Article
The Evolving Role of Mesenchymal Stem Cells and Their Exosomes in Epilepsy Management: From Bench to Bedside
Trial Registration: ClinicalTrials.gov identifier: NCT05886205
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Journal Article
Bone Marrow Mesenchymal Stromal Cells and Their Derived Extracellular Vesicles Protect Pancreatic Beta-TC-6 Cells From Hypoxia-Induced Injury via miR-539-3p-Mediated Downregulation of CD36 Expression
Bone marrow mesenchymal stromal cells (BMSCs) have been shown to enhance the function of pancreatic beta-cells under hypoxic conditions. However, the precise mechanisms underlying this protective effect remain elusive. In this study, we established a hypoxic beta-cell model using murine pancreatic…
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Journal Article
The Size of Human Mesenchymal Tissue Stem Cell Turnover Units is a Major Determinant for Maintaining High Stem Cell Fractions With Serial Culture Expansion
Recently, we used kinetic stem cell (KSC) counting to show that the stability of the stem cell fraction (SCF) during serial culture expansion of human oral alveolar bone mesenchymal tissue cell (MTC) preparations varied significantly among patient donors. Whereas some patient donor samples’ SCFs…
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Journal Article
Mesenchymal Stem Cells Restore Endometrial Integrity and Sustain Pregnancy via CCR7-ERK/JNK Signaling Modulation
Recurrent pregnancy loss (RPL), defined as more than two consecutive miscarriages before 20 weeks of gestation, affects 1%–5% of reproductive-aged women, with nearly half of the cases remaining idiopathic. Using ethanol-induced endometrial injury in rats to simulate RPL, we demonstrated that…
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Journal Article
Intracavernous Injection of Mechanically Extracted Stromal Vascular Fragments Suppresses Endothelial-Mesenchymal Transformation to Mitigate Erectile Dysfunction in Hypertensive Rats
Erectile dysfunction (ED) is widespread among individuals with high blood pressure and negatively affects quality of life. The effect of stromal vascular fraction (SVF) on hypertension-related ED remains unexplored. We used a hypertensive rat model to explore the relative efficacy of adipose tissue…
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Journal Article
Analysis of Primary Cilium-Bearing Human Neuroprogenitors Using Flow Cytometry
The primary cilium is a protruding organelle present on many cell types with important roles for cell signaling. Defects in primary cilium formation and function are linked to numerous pathological conditions including neurodevelopmental defects, aging and cancer. The evaluation of ciliated cells…
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Journal Article
Role of Stem Cells and Stem Cell Markers in Oral Potentially Malignant Disorders and Malignant Transformation: A Systematic Review
Oral potentially malignant disorders (OPMDs) have varying risk of malignant transformation (MT), yet the underlying mechanisms remain unclear. Recent evidence suggest emerging role of stem cells in carcinogenesis. This systematic review aimed to synthesizes current knowledge on the role of stem…
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Journal Article
Evaluation of MSC-Secretome Effects in an Ex Vivo Compartmentalized Osteochondral Interface Model
Trial Registration: ClinicalTrials.gov identifier: NCT04223622
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Journal Article
Regenerative Potential of Mesenchymal Stem Cells for Enhancing Uterine Health and Fertility in Repeat Breeder Dairy Cows
The suboptimal reproductive performance of repeat-breeding (RB) cows is a major challenge for the dairy industry, leading to higher costs, prolonged calving intervals, and reduced productivity, negatively impacting herd productivity and economic viability. Among the associated factors, endometrial…
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Journal Article
Mesenchymal Stem Cells Polarize Macrophages to an Anti-Inflammatory Phenotype to Ameliorate Diabetic Nephropathy
In diabetic nephropathy (DN), classically activated macrophages (M1) are significantly increased, whereas alternatively activated macrophages (M2) are markedly decreased in the renal tissues. Mesenchymal stem cells (MSCs) have been shown to stimulate macrophages from M1 phenotype to M2 phenotype…
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