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Therapeutic Advances in Gastroenterology
Scopus
ISSN 1756-283X · SAGE Publishing · 1,675 articles in the index
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Journal Article
A network meta-analysis on the optimal treatment of malignant gastric outlet obstruction
Background: Gastric outlet obstruction (GOO) caused by malignancy significantly impairs patient quality of life. Surgical gastrojejunostomy (SGJ), endoscopic stenting (ES), and endoscopic ultrasound-guided gastroenterostomy (EUS-GE) are the three main palliative treatments. However, the optimal…
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Journal Article
How does survodutide work? Plain language review of a potential new medication for obesity and liver disease
Summary What is this review about? This review provides an overview of a medication called survodutide. Survodutide is not yet approved for use but is currently being tested to treat people living with obesity , as well as those living with MASH (metabolic dysfunction–associated steatohepatitis)…
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Journal Article
The potential benefit of sodium glucose cotransporter (SGLT)-2 inhibitors in liver cirrhosis: A mini review
Liver cirrhosis represents a growing global health burden and prognosis is determined by the severity of portal hypertension and the development of complications. Among these, kidney dysfunction stands out as one of the strongest predictors of mortality. Sodium–glucose cotransporter-2 (SGLT2)…
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Journal Article
Subcutaneous infliximab for inflammatory bowel disease: Clinical evidence, pharmacokinetics, and implementation challenges
Infliximab (IFX) has traditionally been administered intravenously (IV) for the treatment of moderate-to-severe ulcerative colitis (UC) and Crohn’s disease (CD). Advances in biologic drug delivery and evolving patient preferences have led to the development of subcutaneous (SC) formulations that…
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Journal Article
Prevalence of non-alcoholic fatty liver disease across populations and comorbid conditions: An umbrella review of meta-analyses
Background Non-alcoholic fatty liver disease (NAFLD) affects approximately one-third of the global population, but reported prevalence varies across populations and comorbid conditions. Objectives To characterize the global prevalence of NAFLD across diverse populations and comorbid conditions…
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Journal Article
Facilitated reintroduction of eliminated eosinophilic esophagitis trigger foods with dupilumab
Eosinophilic esophagitis (EoE) is a chronic, type 2 inflammatory disease of the esophagus, characterized by infiltration of eosinophils and symptoms of esophageal dysfunction. EoE is often exacerbated by common trigger foods, such as milk, egg, soy, and wheat, and can be effectively treated by…
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Journal Article
Real-world comparison of second-line infliximab and jak inhibitors for ulcerative colitis after first-line vedolizumab: A comparative multicenter study
Background Vedolizumab (VDZ) is increasingly used as a first-line biologic therapy for moderate-to-severe ulcerative colitis (UC), but evidence on second-line treatment efficacy following VDZ first-line treatment is lacking. Objectives Real-World Comparison of second-line infliximab and jak…
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Journal Article
The Israeli IBD Research Nucleus: collaborative advancements in Israeli IBD research
Inflammatory bowel diseases (IBD) are increasing worldwide, requiring multidisciplinary care and coordinated research infrastructures. Leveraging Israel’s integrated healthcare system with IBD centers of specific and complementary research expertise, a national collaborative consortium was…
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Journal Article
From fresh to frozen: evaluating the feasibility of unprocessed raw stool banking for scalable FMT production
Background: Manufacturing of fecal microbiota transplantation (FMT) products from fresh stool donations poses significant logistical, safety, and scalability challenges. Objectives: To evaluate the technical feasibility of freezing unprocessed, raw stool donations prior to manufacturing to improve…
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Journal Article
Elafibranor in selected patients with primary biliary cholangitis and cirrhosis: An exploratory real-world cohort study
Background Patients with primary biliary cholangitis (PBC) and cirrhosis are a vulnerable population at risk of disease progression and complications. Although elafibranor has shown efficacy in patients with an inadequate response to ursodeoxycholic acid, evidence in individuals with established…
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Journal Article
Acceptability of probiotics, fecal microbiota transplantation, and emerging microbiome-derived therapies in patients with inflammatory bowel diseases: A cross-sectional Survey Study
Background Microbiome-derived therapies (MDT), including probiotics and fecal microbiota transplantation (FMT), represent promising therapeutic approaches in inflammatory bowel disease (IBD). Objectives We aimed to evaluate patient preferences and determinants of MDT acceptability in IBD. Design…
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Journal Article
Age-stratified colonoscopy outcomes and referral-factor associations in the Swedish colorectal cancer fast-track pathway: a retrospective cohort study
Background: The standardised course of care colorectal cancer pathway (SCC-CRC) is a symptom-based fast-track diagnostic pathway. Age-related differences in outcomes and referral-factor associations within different age groups are incompletely described. Objective: To describe colonoscopy outcomes…
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Journal Article
The role of enteroscopy in the diagnosis and interventional management of small intestine diseases
Evaluation of the small intestine is technically difficult because of its length and anatomy. Capsule endoscopy and device-assisted enteroscopy (DAE) have expanded diagnostic and therapeutic options in recent years. This narrative review summarizes the current indications, therapeutic procedures…
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Journal Article
Preliminary research on the effectiveness and safety of metal clip-assisted endoscopic variceal ligation in the treatment of gastric varices
Background: Gastric variceal bleeding is a common and serious complication of liver cirrhosis and carries a high mortality. Endoscopic variceal ligation (EVL) is widely used, but its efficacy for gastric varices is limited by incomplete variceal capture and a high rate of post-ligation rebleeding…
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Journal Article
Patient and physician preferences for treatment of hepatitis C virus infection in Japan: a discrete choice experiment: plain language summary of publication
Summary What is this summary about? This summary explains what both people living with hepatitis C and doctors think is meaningful when treating hepatitis C in Japan. We asked people living with hepatitis C and doctors about their opinions on hepatitis C treatment using a questionnaire. What was…
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Journal Article
Robot-assisted versus conventional endoscopic submucosal dissection: a systematic review and meta-analysis
Background: Robot-assisted endoscopic submucosal dissection (RA-ESD) has been developed to address the ergonomic and technical limitations of conventional ESD (C-ESD). However, the current evidence base remains limited and is predominantly derived from preclinical studies. Objectives: To…
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Journal Article
Efficacy and safety of risankizumab in moderate-to-severe Crohn’s disease: a systematic review and meta-analysis
Background: Crohn’s disease (CD) is a chronic inflammatory disorder with limited therapeutic options for treatment-refractory patients. This meta-analysis evaluates the efficacy and safety of risankizumab (IL-23 p19 inhibitor) in moderate-to-severe CD. Objectives: To evaluate the clinical…
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Journal Article
Impact of wet suction on specimen quality and diagnostic accuracy in EUS-guided tissue acquisition: a systematic review and meta-analysis of randomized controlled trials
Background and aims: Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is critical for diagnosing solid lesions. The wet-suction technique, which pre-fills the needle lumen with saline, has been proposed to improve specimen quality compared with conventional dry suction. This study aimed to…
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Journal Article
Impact of celiac disease on the clinical course of inflammatory bowel disease: CEL_EII study by GETECCU
Background: Inflammatory bowel disease (IBD) and celiac disease (CeD) are immune-mediated digestive disorders with shared genetic, immunological, and environmental risk factors. Objectives: This study aimed to assess whether the coexistence of CeD and IBD is associated with a differential IBD…
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Journal Article
International collaborative experiences in managing pyoderma gangrenosum in patients with inflammatory bowel disease
Pyoderma gangrenosum (PG) is a rare but challenging extraintestinal manifestation (EIM) of inflammatory bowel diseases (IBD), affecting 6%–48% of IBD patients. This retrospective study analyzed affected patients and evaluated therapeutic strategies for both IBD remission and PG resolution. A…
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