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Brazilian Journal of Otorhinolaryngology
Scopus
ISSN 1808-8686 · Elsevier · 2.463 artikel di indeks
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Artikel Jurnal
Genetically predicted plasma metabolites mediate the relation between inflammatory factors and Meniere's disease
Objective: Emerging evidence suggests inflammation contributes to Meniere’s Disease (MD), a chronic vestibular disorder characterized by vertigo, hearing loss, and tinnitus. However, the causal role of Inflammatory Factors (IFs) and the mediating effects of Plasma Metabolites (PMs) in MD remain…
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Artikel Jurnal
Efficacy of Chinese herbal medicine in allergic rhinitis: a meta‐analysis
Objective: To evaluate the clinical efficacy of Chinese Herbal Medicine (CHM) in treating Allergic Rhinitis (AR) through meta‐analysis. Methods: A meta‐analysis was conducted using a random effects model to explore the impact of CHM on response rates, nasal symptom scores, quality of life, blood…
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Artikel Jurnal
Quantitative proteomics analysis to identify biomarkers of refractory benign paroxysmal positional vertigo
Objective: Benign Paroxysmal Positional Vertigo (BPPV) is transient vertigo and paroxysmal nystagmus induced by changes in head position. This study was conducted to investigate the differential expression of serum proteins in patients with refractory BPPV and to screen for diagnostic biomarkers…
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Artikel Jurnal
The emerging role of anti-thymic stromal lymphopoietin monoclonal antibody (Tezepelumab) in comorbid and non-comorbid CRSwNP patients: a scoping review
Objective: This systematic review aims to evaluate the effectiveness of Tezepelumab, a monoclonal antibody targeting the thymic stromal lymphopoietin, in patients affected by chronic rhinosinusitis with nasal polyposis, both with and without comorbid asthma. Methods: A systematic search of the…
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Artikel Jurnal
Brazilian Academy of Paediatric Otorhinolaryngology Task Force – lingual frenulum disorders in childhood – evidence-based recommendations
Objective: To provide evidence-based recommendations for the diagnosis, assessment of functional impact, and management of altered lingual frenulum in children. Methods: Task force members were educated on knowledge synthesis methods, including electronic database search, review and selection of…
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Artikel Jurnal
Genetic diagnosis of macrotia in PIK3CA-Related Overgrowth Spectrum (PROS) and long-term outcome of otoplasty: a case report and literature review
Objectives: PIK3CA-Related Overgrowth Spectrum (PROS) is a highly heterogeneous disease. Facial Infiltrating Lipomatosis (FIL) is a rare PROS subset, and its atypical phenotypes, such as macrotia, present diagnostic and therapeutic challenges due to limited data. This study aims to detail the…
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Artikel Jurnal
Efficacy and safety of corticosteroids in the management of chronic rhinosinusitis: A systematic review and meta-analysis of randomized and non-randomized studies
Objective: To evaluate the efficacy and safety of corticosteroids in Chronic Rhinosinusitis (CRS), focusing on health-related quality of life, disease severity, systemic steroid-sparing effects, and Serious Adverse Events (SAEs). Methods: Following PRISMA 2020 guidelines, PubMed, Web of Science…
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Artikel Jurnal
Nomogram for predicting cognitive impairment in middle-aged and elderly individuals with self-reported hearing loss: Insights from the longitudinal CHARLS cohort
Objective: To develop and evaluate a predictive model for cognitive impairment, assessed by a brief cognitive test, among middle-aged and older adults with self-reported hearing loss, aiming to facilitate early identification and targeted intervention in high-risk populations. Methods: This study…
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Artikel Jurnal
An affordable and optimized 3D biomodel for sinonasal surgery training
Objectives: To develop and evaluate the anatomical accuracy and haptic fidelity of an affordable kit consisting of a silicone head, a foam support, and a 3D-printed biomodel of the paranasal sinuses for surgical training. Methods: This single-center, technological, and interventional study detailed…
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Artikel Jurnal
Combined endoscopic and open frontolateral laryngectomy for glottic tumors involving the anterior commissure
Objective: The combined endoscopic and open frontolateral laryngectomy technique has been proposed to balance oncologic safety with functional preservation in the management of glottic tumors involving the Anterior Commissure (AC). This study aims to describe this technique in detail, its…
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Artikel Jurnal
Association of triglyceride and cholesterol with vestibular vertigo: Evidence from univariable and multivariable mendelian randomization and mediation analysis
Objectives: This study aimed to use Mendelian Randomization (MR) method to explore the potential causal association of triglyceride and cholesterol on the risk of vestibular vertigo and potential mediating factors. Methods: We extracted genetic variants associated with triglyceride and cholesterol…
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Artikel Jurnal
Image-guided protocol with a guide-marker for bone conduction hearing implant placement estimation
Objective: To propose a protocol for image-guided implant placement estimation, combining 3D reconstruction of preoperative Computed Tomography (CT) images and a guide-marker, for individuals undergoing percutaneous Bone Conduction Hearing Devices (BCHD). Methods: Fifty-one subjects aged 6- to…
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Artikel Jurnal
Discriminative validity and diagnostic accuracy of Horus® posturographic parameters in individuals with and without vestibulopathy
Objective: To assess the discriminative validity and diagnostic accuracy of posturographic parameters from the Horus® in individuals with and without vestibulopathy. Methods: This is a methodological study of discriminative validity and diagnostic accuracy. 153 individuals aged 40–79, of both…
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Artikel Jurnal
P16INK4a protein expression associated with Head and Neck Squamous Cell Carcinoma: A perspective of a public health reference service in São Paulo
Objectives: Human Papillomavirus (HPV) may be a predictive biomarker predictor for clinical outcome and influence treatment decisions in patients with Head and Neck Squamous Cell Carcinoma (HNSCC). Methods: We evaluated 253 patients with HNSCC from state of São Paulo, Brazil. The influence of…
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Artikel Jurnal
Explainable machine learning model for predicting hearing recovery in unilateral sudden sensorineural hearing loss
Objective: Sudden Sensorineural Hearing Loss (SSNHL) is routinely encountered in otolaryngology clinics. The prognosis of SSNHL varies dramatically and depends on multiple influence factors. This study aimed to develop an explainable Machine Learning (ML) model with easily accessible features to…
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Artikel Jurnal
miR-199a-5p inhibits malignant progression and enhances cisplatin sensitivity of nasopharyngeal carcinoma by targeting SLC1A5
Objective: The prevalence of Nasopharyngeal Carcinoma (NPC) is increasing, and the mortality of patients with cisplatin resistance is high. In this study, we aimed to elucidate several potential mechanisms of miR-199a-5p in regulating the progression and cisplatin resistance of NPC. Methods…
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