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Clinical Epigenetics
Scopus
ISSN 1868-7075 · BMC · 1,152 articles in the index
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Journal Article
Characterization and clinical implications of CpG island methylator phenotypes of resistant tumors
Abstract Background Drug resistance, characterized by high heterogeneity and complex mechanisms, poses a significant challenge in cancer treatment. Stratifying resistant tumors into biologically and clinically meaningful subgroups can improve prognostic evaluation and help guide treatment…
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Journal Article
Epigenome-wide association study of leukocyte telomere length and their effects on smoking-induced lung tumorigenesis: insights from the Dongfeng-Tongji cohort study
Abstract Background Epigenetic factors underlying telomere length (TL) may provide insight into telomeric homeostasis, with direct links to cigarette smoking and lung cancer susceptibility. It is unclear, nevertheless, to what extent effects of TL and its related DNA methylation on the…
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Journal Article
Genome-wide DNA methylation patterns for indicators of liver steatosis: a longitudinal multiomic study
Abstract Background To identify blood DNA methylation profiles related to liver steatosis, we performed an EWAS on the presence of ultrasonically-identified liver steatosis in the Young Finns Study (YFS) participants (n = 1529, 33–50y.), and on liver enzyme levels and fatty liver index (FLI) across…
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Journal Article
Association between cardiovascular health and epigenetic aging: a twin study
Abstract Objective To explore the association between life’s essential 8 and epigenetic age based on twins population. Methods This study included 1030 twins (515 pairs) for cross-sectional analysis and conducted cross-lagged analysis among 294 twins (147 pairs) who participated in both the…
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Journal Article
Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trial
Abstract Background DNA methylation plays an important role in systemic lupus erythematosus (SLE) pathogenesis by regulating immune cell function and disease progression. Dietary factors, particularly methyl-donor micronutrients such as folic acid and vitamin B12, may influence DNA methylation…
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Journal Article
Blood DNA methylation-predicted plasma protein levels and colorectal cancer survival
Background Protein EpiScores are a novel class of DNA methylation (DNAm)-based metrics proposed to measure peripheral immune system characteristics. Although Protein EpiScores have been associated with chronic disease risk, their relationship with colorectal cancer (CRC) survival has not been…
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Journal Article
Modeling mammalian meiosis with pluripotent stem cells: progress and challenges
Abstract Meiosis is a specialized cell division producing haploid gametes from diploid germ cells and is vital to sexual reproduction in mammals. This process entails carefully regulated molecular events including double-strand break repair, remodeling of the chromatin and the segregation of the…
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Journal Article
HIV associated epigenetic trends and chronic diseases: insights into the hidden burden of chronic infection
Abstract Human Immunodeficiency Virus (HIV) remains a major health challenge despite dramatic advances in treatment and prevention. People living with HIV (PLWH) continue to experience high rates of non-AIDS comorbidities, including cardiovascular, renal, pulmonary, oncologic, and neurocognitive…
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Journal Article
HDAC11 interacts with the NuRD (MTA3) complex to transcriptionally suppress TGFβ1 expression and inhibit hepatocellular carcinoma metastasis
Abstract Hepatocellular carcinoma (HCC) is a leading global health concern, recognized for its complex pathogenesis and high mortality rates. The metastatic progression of HCC, considered the terminal event in tumor development, plays a pivotal role in determining patient prognosis, with metastasis…
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Journal Article
Smoking behaviour, altered DNA methylation, and heart failure risk: evidence from a prospective cohort and epigenetic Mendelian randomization study
Abstract Background To date, there is still a lack of studies focusing on the interactions between tobacco smoking, epigenetic modifications, and heart failure (HF) risk. Methods We first performed a prospective cohort study in the UK Biobank to assess the causal relationship between smoking…
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Journal Article
Single-cell transcriptomics uncover RNF130-mediated TNF-α pathway activation and worenine synergy with paclitaxel in breast cancer
Abstract Background Triple-negative breast cancer (TNBC) is distinguished by high invasiveness and a tendency for recurrence. Recent studies have suggested that E3 ubiquitin ligases play a crucial role in the initiation and progression of various tumors. However, there is still an absence of…
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Journal Article
Differential transcriptomic modulation by histone deacetylase inhibitor SAHA in LUAD and LUSC
Abstract Background Histone deacetylases (HDACs) are central epigenetic regulators in non-small cell lung cancer (NSCLC), yet responses to HDAC inhibitors (HDACi) vary markedly between lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC). We asked how the pan-HDAC inhibitor suberoylanilide…
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Journal Article
The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis
Abstract Adverse childhood experiences (ACEs), such as abuse and neglect, are associated with poor health in adulthood. One proposed biological mechanism linking early adversity to health outcomes is epigenetic age acceleration (EAA), a measure of biological aging derived from DNA methylation…
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Journal Article
Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson’s disease
Abstract Background Histone deacetylases (HDACs) are epigenetic molecules responsible for regulation of gene transcription. Dysregulation of HDACs has been linked to neurodegenerative disease. Here, we used the class I HDAC PET radioligand [11C]Martinostat to quantify and map changes in the…
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Journal Article
Epigenomic subtypes and prognostic methylation signatures in clear cell renal cell carcinoma
Abstract Background Clear cell renal cell carcinoma (ccRCC) is characterized by marked epigenetic dysregulation, contributing to aberrant gene expression and tumor progression. To expand current knowledge on genome-wide methylation patterns in ccRCC, we performed Methylated DNA Immunoprecipitation…
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Journal Article
Dual epigenetic and nuclear export inhibition by chidamide and selinexor in high grade B-cell lymphomas via survivin and PI3K/AKT inhibition
Abstract Backgound High-grade B-cell lymphoma with concurrent MYC and BCL2/BCL6 rearrangements (HGBL-DHL) is a highly aggressive disease that is resistant to conventional first-line immunochemotherapeutic regimens. This resistance necessitates the exploration of innovative therapeutic strategies…
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Journal Article
Epigenetic clocks can differentiate between exogenous and endogenous skin ageing
Abstract Context Whereas factors originating internally to the body, such as blood nutrients and hormones, influence endogenous skin ageing, exogenous skin ageing results from the penetration of harmful factors through the skin’s outer stratum corneum layer. Aim To test whether an exogenous skin…
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Journal Article
Accelerated biological aging and underlying epigenetic modification mediated the association between obesity and asthma
Abstract Background The relationships among obesity, accelerated biological aging, and asthma, as well as the underlying epigenetic mechanisms, remain incompletely understood. Methods We conducted a prospective cohort study in the UK Biobank to evaluate whether accelerated biological aging mediates…
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Journal Article
Azacitidine and decitabine show distinct response patterns in pediatric Myelodysplastic Syndromes and Juvenile Myelomonocytic Leukemia before HSCT: a systematic review and quantitative analysis
Abstract Background Epigenetic dysregulation is a key therapeutic target in pediatric hematologic malignancies resistant to conventional chemotherapy, where allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative option. In this setting, hypomethylating agents (HMAs)…
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