27.677 hasil
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PLoS Neglected Tropical Diseases
Scopus
ISSN 1935-2735 · Public Library of Science (PLoS) · 27.677 artikel di indeks
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Artikel Jurnal
Onchocerciasis and non-communicable diseases in the Bafut Health District, Cameroon: Knowledge, attitudes, and practices towards community-directed treatment with ivermectin.
BackgroundOnchocerciasis remains a public health problem in Cameroon despite years of community-directed treatment with ivermectin (CDTI). Its persistence increasingly overlaps with the rising burden of non-communicable diseases (NCDs). Community knowledge, attitudes, and practices (KAP) toward…
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Artikel Jurnal
Assessment of the efficacy and safety of two albendazole regimens for the treatment of hypermicrofilaraemic loiasis in adults in Woleu-Ntem Province, Gabon: A phase IIb single-blind randomised controlled trial.
BackgroundLoa (L.) loa hypermicrofilaraemia (≥ 8,000 mf/mL) increases the risk of severe adverse events during mass ivermectin administration for onchocerciasis control. Albendazole has been proposed as a potential alternative for reducing microfilaraemia prior to ivermectin…
Juga tersedia di: DOAJ
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Artikel Jurnal
Leptospirosis in the Caribbean Region between 2000 and 2022: A scoping review of morbidity and mortality.
BackgroundLeptospirosis remains an important yet underreported public health concern in the Caribbean. Urbanisation, biodiversity loss and human encroachment into natural habitats have contributed to shifts in its epidemiological patterns. However, accurate assessment of disease burden is hindered…
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Artikel Jurnal
Analysis of Phlebotomine sandflies in Laos from 2014-2024: Inventory, description of a new species, screening for Leishmania and detection of Trypanosoma.
IntroductionPhlebotomine sandflies are the principal vectors of leishmaniasis. Laos is a landlocked country bordering Thailand, where autochthonous cases of leishmaniasis have been reported. However, the status of leishmaniases in Laos is unknown due to a lack of testing. In the past decades, very…
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Artikel Jurnal
Attenuated viral strains of priority pathogens for potential use in controlled human infection model studies: A scoping review.
BackgroundThere are several known pathogens and families identified as high risk for pandemic potential. It is essential to study these pathogens and develop medical countermeasures to mitigate disease prior to potential pandemics. Controlled human infection models (CHIMs) using attenuated viral…
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Artikel Jurnal
Bridging the knowledge gap: Thai parents' perspectives on dengue infection and its vaccination and the need for targeted promotion.
BackgroundDengue infection is endemic in Thailand, with children being the most impacted group. Various measures, including the dengue vaccine (recently recommended in Thailand since 2017 for Dengvaxia and 2023 for Qdenga), have been implemented to prevent and manage the disease. However, the rate…
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Artikel Jurnal
Arboviruses circulation in Guinea: Overview and perspectives for public health.
BackgroundArboviruses constitute a major global public health concern, particularly in countries with fragile healthcare systems. However, data on arbovirus circulation remain fragmented and under-analysed. This study aimed to document the historical and current circulation of arboviruses in Guinea…
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Community knowledge, attitudes, and practices toward cutaneous leishmaniasis in central Ethiopia.
BackgroundCutaneous leishmaniasis is the most prevalent clinical form of leishmaniasis and remains a significant public health problem, particularly in low- and middle-income countries where it disproportionately affects disadvantaged populations. The disease causes a far-reaching impact to the…
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Artikel Jurnal
A systematic review and meta-analysis of knowledge, attitudes, and practices toward anthrax prevention and control in Ethiopia: Implication for a one health policy.
BackgroundAnthrax is one of the tropical diseases that are often overlooked... Anthrax's burden extends beyond its effects on health; it also has an economic cost. Implementing One Health policies requires knowledge, attitude, and practice (KAP) about anthrax prevention and control. However, there…
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Artikel Jurnal
Targeting Leishmania donovani Sphingosine Kinase 1 using PF-543 enhances immune response and limits parasite load.
BackgroundSphingosine-1-phosphate (S1P) is a bioactive lipid mediator regulating apoptosis, proliferation, and immune responses. While S1Ps presence in Leishmania donovani phagolysosomes has been reported, the role of sphingosine kinases, especially SphK1, in parasite survival and host immune…
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Artikel Jurnal
Microbiota-derived indole differentially shapes Entamoeba histolytica physiology and promotes host-compatible colonization.
Entamoeba histolytica is a pathogenic amoeba that colonizes the human large intestine and causes amoebiasis. In its natural gut environment, the parasite is exposed to microbiota-derived metabolites, including indole, a tryptophan-derived compound present at millimolar concentrations, whereas…
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Artikel Jurnal
One health at the last mile: Multi-scale predictors of Schistosoma japonicum infection in southwest China across two decades of control.
In China, schistosomiasis is targeted for elimination. As the country approaches elimination, it is critical to evaluate how the dynamics of transmission are changing in remaining pockets of disease. We have been studying areas of schistosomiasis reemergence and persistence in Sichuan, China since…
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Artikel Jurnal
Maternal expression and breast milk transfer of an mRNA- encoded monoclonal antibody in a murine model of cholera.
Breast milk confers infants with immunity to a multitude of pathogens reflective of prior maternal infections and vaccinations. However, in outbreak situations where infants may be vulnerable to lethal infections due to gaps in the maternal immune repertoire, a case can be made for supplementing…
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Artikel Jurnal
LAMP-coupled CRISPR-Cas12a assays: A promising new tool for molecular diagnosis of leishmaniasis.
BackgroundTegumentary leishmaniasis is a parasitic disease endemic in the Americas. Its clinical management and control rely on early and accurate diagnosis and adequate treatment. PCR-based molecular diagnostics offer high sensitivity and specificity over microscopy or culture but are less…
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