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Gut Microbes
Scopus
ISSN 1949-0976 · Taylor & Francis Group · 2,142 articles in the index
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Journal Article
Gut‒heart axis: emerging therapies targeting trimethylamine N-oxide production
Trimethylamine N-oxide (TMAO) has garnered considerable attention because of its role in the pathophysiology and pathogenesis of various disorders, particularly heart and kidney disease. Gut microbes produce trimethylamine (TMA) moieties from common dietary precursors, such as choline or carnitine…
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Journal Article
Muribaculum intestinale negatively impacts glioma growth in mice through the toll-like receptor 2
Glioblastoma (GBM) is the most common and malignant brain tumor in adult humans. Recent studies have demonstrated a link between the composition of the gut microbiota and glioma progression. Here, we describe that the growth of glioma in mice is inversely correlated with the relative abundance of…
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Journal Article
Fusobacterium nucleatum plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation
Gut microbiota dysbiosis has been implicated in the pathogenesis of irritable bowel syndrome (IBS), a globally prevalent functional gastrointestinal disorder; however, mechanistic insights remain limited. We determined that the bacterium Fusobacterium nucleatum (F. nucleatum) played a pathogenic…
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Journal Article
Akkermansia muciniphila's nifJ gene enhances colostrum sIgA synthesis by branched-chain amino acid degradation to branched short-chain fatty acids
Colostrum secretory immunoglobulin A (sIgA) confers the first immune defense line for neonates to adapt to the external environment, while gut microbes have received attention for their high reactivity with sIgA. Here, we report that high levels of sIgA in sow colostrum are associated with the…
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Journal Article
Microbial extracellular vesicles from min pigs remodel macrophage polarization via STING to sustain intestinal immune homeostasis
Intestinal immune homeostasis is crucial for intestinal function and health. Increasing evidence suggests that certain gut microbiota can enhance the host's intestinal immune regulatory capacity. However, the mechanisms by which the microbiota confers beneficial traits and robust immunity to the…
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Journal Article
Improving ulcerative colitis prospects through fecal microbiota transfer: atypical donor microbiota can boost success rate
Fecal microbiota transfer (FMT) has been used with variable success in the experimental treatment of ulcerative colitis (UC), and efforts to improve its efficacy very much remain a matter of trial and error. We recently predicted that atypical donor microbiota could improve results. Here, we…
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Journal Article
Gut microbiome remodeling induced by microplastic exposure in humans
The impact of microplastics (MPs) on the diversity and composition of the gut microbiome has been extensively documented in animal studies, but evidence in humans remains limited. Recognizing the potential differences in MP effects between animal and human gut microbiomes, this review synthesizes…
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Journal Article
The enteric DNA virome differs in infants at risk for atopic disease
Atopic disease prevalence, including atopic dermatitis, food allergy, asthma, and allergic rhinitis, has risen dramatically in industrialized countries. Traditional, single family farming lifestyles protect against atopic disease, but the mechanisms are incompletely understood. While there are…
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Journal Article
A novel exopolysaccharide from Lactiplantibacillus plantarum H6 improves cholesterol metabolism via Muribaculum-mediated activation of the enterohepatic FXR–FGF15 axis
Hypercholesterolemia is a major risk factor for atherosclerotic cardiovascular disease; however, current therapeutic options such as statins are limited by issues including hepatotoxicity and patient intolerance. Probiotics and their metabolites show promise in modulating cholesterol metabolism…
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Journal Article
Gut microbial ammonia as a mediator of PFOS neurotoxicity and its remediation by the flavonoid Icaritin
Perfluorooctane sulfonate (PFOS), a persistent environmental pollutant, is associated with cognitive dysfunction through mechanisms involving neuroinflammation, oxidative stress, and metabolic disruption. Icaritin, a bioactive flavonoid with antioxidant and anti-inflammatory properties, exhibits…
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Journal Article
Self-aggregating Lactiplantibacillus plantarum enhances type-I interferon responses via the cytosolic sensors NOD2 and cGAS
The gut microbiome plays a critical role in health, disease and immunity. To date, we have access to large datasets describing how the microbial diversity present in the gut correlates with many clinical conditions. However, the microbiome composition is taxonomically complex; influenced by many…
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Journal Article
Akkermansia muciniphila modulates intestinal mucus composition to counteract high-fat diet-induced obesity in mice
Objective This study investigates whether live Akkermansia muciniphila MucT supplementation can counteract obesity and metabolic dysfunctions induced by a high-fat diet (HFD) by modulating intestinal mucus production, secretion and composition.Design C57BL/6J mice were fed an HFD with or without…
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Journal Article
Peptidoglycan from Bifidobacterium adolescentis enhances IL-10 production in regulatory B cells to alleviate gut inflammation
The mechanisms by which gut microbiota modulate host immune responses remain incompletely understood. Here, we screened Lactobacillus and Bifidobacterium strains isolated from healthy individuals to identify symbionts capable of suppressing gut inflammation. Among them, Bifidobacterium adolescentis…
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Journal Article
Induction of DNA-mediated immune responses by bacterial extracellular vesicles results in control of murine norovirus infection
Commensal bacteria have been a centerpiece for understanding interkingdom impacts on viral replication. Multiple groups have investigated the roles commensal bacteria played in regulating enteric virus infection and it has been found that the mechanisms through which this regulation occurs varies…
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Journal Article
Early risk stratification of late-onset sepsis in very preterm infants by intestinal microbiota profiling: a multicenter case–control validation study
Intestinal bacterial translocation to the bloodstream is a route of infection for late-onset sepsis (LOS) in preterm infants, highlighting the potential of fecal microbiota profiling for early risk stratification. We aimed to identify and validate LOS-specific gut microbiota signatures. Fifty-eight…
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Journal Article
Natural microbiota confer life-long protection against obesity via an early-life, immune-mediated effect on brown adipocytes
Obesity, a major risk factor for metabolic disease, has increased in industrialized nations alongside a reduction in gut microbiota diversity. Reconstituting laboratory mice with complex, natural microbiota and commensals from wild mice resulted in protection against diet-induced obesity. These…
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Journal Article
Gut microbiome-derived propionate reprograms alveolar macrophages metabolically and regulates lung injury responses in mice
Responses to lung injury can vary between individuals with the diet and gut microbiome representing two underappreciated sources for this variability. The gut microbiome can influence lung injury outcomes through the gut‒lung axis, but exactly how diet and its effects on the microbiota are involved…
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Journal Article
Intestinal epithelial TLR4 knock out induces sex-specific effects on gut barrier and microbiome in an activity-based anorexia model
The role of the microbiota‒gut‒brain axis in the pathophysiology of anorexia nervosa has emerged in recent decades. Increased expression of Toll-like receptor 4 (TLR4) has been reported in the intestinal epithelial cells (IEC) of activity-based anorexia (ABA) mice. The inducible TLR4 knockout in…
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Journal Article
Helicobacter pylori induces the production of interleukin-37 to promote broad immunosuppression and enhance colonization
Helicobacter pylori infects approximately half of the world’s population, resulting in lifelong gastric infections. To promote lifelong colonization, H. pylori modulates host immunity via unknown mechanisms. Here we show that H. pylori can harness the pan-immunosuppressive cytokine interleukin-37…
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