1,027 results
Showing 1–20 · 0.25 seconds · RSS
Bangladesh Journal of Pharmacology
Scopus
ISSN 1991-007X · Bangladesh Pharmacological Society · 1,027 articles in the index
-
Journal Article
Protective effects of ethanolic leaf extract of Medicago sativa against complete Freund's adjuvant-induced arthritis in Wistar rats
This study evaluated the antiarthritic activity of the ethanolic leaf extract of Medicago sativa through phytochemical screening and a complete Freund's adjuvant-induced arthritis model in Wistar rats. Phytochemical screening revealed the presence of alkaloids, tannins, phenolics, flavonoids…
-
Journal Article
microRNA-370-5p inhibits non-small cell lung cancer cell proliferation and migration and promotes apoptosis by targeting KPNA3
This study aimed to investigate the biological function of microRNA-370-5p (miR-370-5p) in non-small cell lung cancer (NSCLC) and its regulatory relationship with KPNA3. The expression levels of miR-370-5p and KPNA3 were examined in 72 NSCLC tissue samples and matched adjacent non-tumor tissues, as…
-
Journal Article
Integrated LC–MS-guided phytochemical profiling, molecular docking, and in vitro validation of Sauromatum venosum extracts against colorectal cancer
The antioxidant, phytochemical, and anti-colorectal cancer potential of Sauromatum venosum leaf and tuber extracts were investigated using experimental and computational approaches. Hydroalcoholic, aqueous, and ethyl acetate extracts were evaluated using DPPH assay. Hydroalcoholic leaf (L1) and…
-
Journal Article
Effect of hydroethanolic extract of Butea monosperma flower on bleomycin-induced pulmonary fibrosis in mice via IL-6 modulation
This study evaluates the antifibrotic and anti-inflammatory potential of a hydroethanolic extract of Butea monosperma flowers in bleomycin-induced pulmonary fibrosis in Swiss albino mice. The extract (100 and 200 mg/kg orally) was administered for 21 days following oropharyngeal aspiration of…
-
Journal Article
Cuscuta chinensis ethanol extract suppresses H22 hepatoma growth in mice and reduces PI3K/AKT phosphorylation
This study evaluated the effects of Cuscuta chinensis ethanol extract in H22 hepatoma-bearing mice. Tumor-bearing mice were treated with cyclophos-phamide or varying doses of the extract for 14 days. Tumor growth was assessed using bioluminescence imaging and tumor weight measurements. The extract…
-
Journal Article
Sinomenine promotes neuronal differentiation and neurite out-growth via Akt activation in vitro
Sinomenine, a bioactive alkaloid from Sinomenium acutum, exhibits anti-inflammatory and neuroprotective effects, but its role in neuronal differentiation and morphological maturation remains unclear. This study used Neuro-2a cells and primary neural stem/progenitor cells (NSPCs) to examine the…
-
Journal Article
In vitro antiproliferative activity of Dracaena fragrans ‘Lemon Lime’ on MCF-7 breast cancer cell lines
This study aimed to evaluate the in vitro antiproliferative activity of leaves of Dracaena fragrans ‘Lemon Lime’ on MCF-7 breast cancer cell lines. Phytoconstituents were extracted from leaves, and their total flavonoid contents were measured. Cell viability of cell lines was assessed by the MTT…
-
Journal Article
Antitumor effects of metformin or atorvastatin as adjuvant therapies to neoadjuvant chemotherapy in non-metastatic breast cancer
Breast cancer remains the most common life-threatening malignancy among women worldwide. This randomized, placebo-controlled study evaluated the antitumor effects of metformin or atorvastatin as adjuvant therapies combined with neoadjuvant chemotherapy in 90 patients with non-metastatic breast…
-
Journal Article
Hepatoprotective effect of Pluchea pteropoda extract against CCl4-induced hepatotoxicity
This study aimed to evaluate the hepatoprotective effects of P. pteropoda extract against carbon tetrachloride (CCl4)-induced hepatotoxicity. The extraction condition was due to ethanol 50%, a solid-to-solvent ratio of 1:10, extraction temperature of 60°C, and extraction time of 4 hours…
-
Journal Article
Effects of ethanolic leaf extract of Gynura divaricata on NF-κB pathway in human HeLa cells
This study aims to evaluate the anti-cancer activity of the ethanolic leaf extract of Gynura divaricata in human cervical cancer HeLa cells. Cells were treated with various concentrations of extract, and cell viability was assessed to determine the half-maximal inhibitory concentration (IC50). The…
-
Journal Article
Anti-arthritic activity of Alternanthera paronychioides through suppression of inflammatory cytokines and NF-κB signaling
Alternanthera paronychioides is traditionally used for managing inflammatory disorders; however, its anti-arthritic efficacy and underlying mechanisms remain insufficiently characterized. The present study evaluated the anti-arthritic potential of A. paronychioides in acute and chronic animal…
-
Journal Article
Tangeretin suppresses HER2-driven breast cancer via PI3K/AKT/mTOR inhibition and caspase-dependent apoptosis
Tangeretin, a citrus-derived polymethoxylated flavone, exhibits potent and selective anti-cancer activity against HER2-positive breast cancer. It demonstrated cytotoxicity in SKBR3 cells (IC₅₀ = 19.5 ± 1.7 µM) and MCF-7 cells (IC₅₀ = 36.2 ± 2.4 µM), while sparing non-tumorigenic MCF-10A cells (>90%…
-
Journal Article
Effectiveness of Artemisia pallens against behavioral depression and impact on monoaminergic and GABAergic systems
Depression is characterized by decreased monoamine levels (dopamine, noradrenaline, serotonin), gamma-aminobutyric acid (GABA), elevated corticosterone, and dysregulation of the hypothalamic-pituitary-adrenal axis. This study aims to examine the effects of Artemisia pallens against behavioral…
-
Journal Article
2-Methoxy-6-acetyl-7-methyljuglone, a natural naphthoquinone from Polygonum cuspidatum, protects against 6-OHDA-induced neurotoxicity in PC12 cells
This study investigated the neuroprotective effects of 2-methoxy-6-acetyl-7-methyljuglone (MAM, a compound isolated from Polygonum cuspidatum) in 6-hydroxydopamine (6-OHDA)-injuried pheochromocytoma (PC12) cells. 6-OHDA treatment significantly induced cell death, apoptosis and mitochondrial…
-
Journal Article
Neuroprotective effect of juglone against 6-OHDA-induced neurotoxicity in PC12 cells
No abstract
-
Journal Article
Anti-tumor activity of Simarouba glauca on Ehrlich ascites carcinoma in mice
This study aimed to evaluate the anti-cancer potential of the ethanolic extract of Simarouba glauca leaf in Ehrlich ascites carcinoma-bearing Swiss albino mice. Ehrlich ascites carcinoma was induced by intraperitoneal injection of 1 × 10⁶ viable cells in each mouse. The extract (150 or 300 mg/kg)…
-
Journal Article
Novel CRT2 peptide inhibits tumor growth and angiogenesis in colorectal cancer HT-116 cell lines via PI3K/ERK signaling pathway
This study aims to evaluate the efficacy of the CRT2 peptide in inhibiting VEGFR1 tyrosine kinase activity against solid tumors. Molecular docking was performed using Cluspro 2.0 against the vascular endothelial growth factor receptor-1 (VEGFR1) with CRT2. Moreover, in vitro studies were conducted…
-
Journal Article
Cytotoxic effect of Luffa cylindrica leaf extract on MCF-7 cell lines
This study investigated the cytotoxic effect of Luffa cylindrica leaf aqueous ethanolic extract on breast cancer cell lines MCF-7 and the normal epithelial cell line MCF-10A. Phytochemical screening and DPPH assays confirmed the presence of antioxidant compounds. MTT showed a dose-dependent…
-
Journal Article
Antiproliferative activity of Tribulus terrestris stem bark extract against A431 cells
Not available
-
Journal Article
Ginkgolide B alleviates renal and podocyte injury in membranous nephropathy by inhibiting ferroptosis
This study investigated whether ginkgolide B alleviates renal and podocyte injury in membranous nephropathy by inhibiting ferroptosis. Rats with passive Heymann nephritis received ginkgolide B (7.5 mg/kg/day) or vehicle. Ginkgolide B significantly ameliorated nephrotic syndrome, reducing 24-hour…
Showing at most 50 pages. Narrow your search with filters for more specific results.