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Programme Grants for Applied Research
Scopus
ISSN 2050-4322 · NIHR Journals Library · 160 articles in the index
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Journal Article
Improving outcomes when care homes close: NIHR Programme Grant multi-methods study
Background When care homes close, it can be detrimental to older people’s well-being. However, there is little formal evidence to guide services when undertaking such important work. Objectives This study explores what happens when homes close, how best to minimise negative outcomes for older…
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Journal Article
Promoting activity, independence and stability in early dementia and mild cognitive impairment: the PrAISED research programme including an RCT
Background Dementia represents a major public health challenge worldwide. Interventions are required to maintain functional ability and prevent crises. Exercise-based therapy may improve activities of daily living and prevent falls. Objective We aimed to systematically develop an intervention…
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Journal Article
Digital intervention to support cancer survivors: the CLASP research programme
Background There are increasing numbers of cancer survivors who have finished their primary treatment, but whose quality of life remains consistently poor over years. There is limited evidence for pragmatic, brief interventions to support cancer survivors in primary care, where most patients are…
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Journal Article
Avoiding patient harm through the application of prescribing safety indicators in English general practices: the PRoTeCT research programme evaluating OptimiseRx and PINCER
Background Hazardous prescribing is an important and expensive preventable cause of patient harm, which can be identified using electronic healthcare records. In our Programme Grant we investigated the large-scale roll-out of a type of clinical decision support called OptimiseRx® (First Databank…
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Journal Article
Behavioural intervention to improve sleep in childhood epilepsy: the CASTLE RCT programme
Background Sleep problems are common in young people with epilepsy and neurodevelopmental disorders, impacting learning, behaviour and family function. Sleep disturbances can trigger seizures, which in turn disrupt sleep, creating a vicious cycle. Available behavioural interventions have been…
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Journal Article
Development and evaluation of personalised post-diagnostic dementia support based in primary care: the D-PACT research programme
Background Dementia affects nearly 1 million people in the United Kingdom and their unpaid carers physically, psychologically, socially and economically, highlighting that both need support. Post-diagnostic support is recognised as inadequate globally. In England, it is fragmented or absent apart…
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Journal Article
Living well with Crohn’s & Colitis fatigue, pain and urgency/faecal incontinence: the IBD-BOOST research programme including an RCT
Background Inflammatory bowel disease (IBD) adversely impacts the quality of life. Healthcare professionals target treatment at controlling gut inflammation. However, patients report troublesome symptoms of fatigue, abdominal pain and urgency or faecal incontinence in the absence of inflammation…
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Journal Article
Scalable low-cost interventions to support medication adherence in people prescribed treatment for hypertension in primary care: a research programme
Background About 14.9% of people (9.9 million) registered with primary care practices in England and Wales are prescribed medication for hypertension. However, many do not take their medication as prescribed. To address this problem, we need scalable interventions. Objective To develop a scalable…
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Journal Article
Tackling chronic depression, adapting and testing the DIALOG+ solution-focused approach for people with long-term depression: the TACK mixed-methods research programme
Background Long-term (previously termed chronic) depression is associated with significant personal, social and economic consequences often resulting in a poor quality of life for individuals. Effective treatments that improve quality of life for individuals with chronic depression remain limited…
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Journal Article
Scalable behavioural weight management programmes for the prevention and treatment of type 2 diabetes: research programme including three RCTs
Background Behavioural weight management programmes can prevent type 2 diabetes and reduce risk factors for complications and medication use in those with type 2 diabetes. However, few are sufficiently scalable, and weight is typically regained. We evaluated whether scalable behavioural weight…
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Journal Article
A lifelong approach to promote effective self-management in adults with type 1 diabetes: the DAFNEplus research programme including a cluster RCT
Background Dose Adjustment For Normal Eating is a 5-day, group-based clinical education programme for adults with type 1 diabetes, training them in the complex self-management skills, enabling them to optimise both their glycaemic management and quality of life. Although Dose Adjustment For Normal…
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Journal Article
Development and testing of an intervention to improve recovery after an episode of delirium: the RecoverED research programme
Background Delirium is a common neurocognitive disorder in older adults and is associated with poor outcomes. Cognitive, mood and functional deficits can persist for months following an episode, impacting long-term well-being. While previous research has focused on delirium prevention and…
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Journal Article
Engaging adolescents in changing behaviour to improve diet and physical activity levels in teenagers: the EACH-B research programme
Background Globally, the health of young people is in decline, with increasing rates of mental health issues, obesity and sedentary lifestyles. Existing health behaviour change interventions for this group face challenges in engagement and implementation. Effective, targeted interventions are…
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Journal Article
Transforming the mental health treatment of young people with epilepsy: the MICE research programme including a RCT
Background Children and young people with epilepsy are significantly more likely to experience multiple mental health problems, including anxiety, depression and behavioural difficulties, compared to youth without chronic physical health needs. Yet the majority of mental health problems go…
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Journal Article
Development and evaluation of a complex ePrescribing-based Antimicrobial Stewardship (ePAMS+) intervention for hospitals: a mixed method study
Aims To develop, assess the feasibility and test the effectiveness and cost-effectiveness of a multifaceted ePrescribing-based Antimicrobial Stewardship intervention to safely reduce inappropriate antibiotic use in adult medical inpatient settings. Methods We undertook a mixed-methods programme of…
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Journal Article
Optimising antibiotic ‘review and revise’ in acute/general medical inpatients: the Antibiotic Review Kit in Hospitals (ARK-Hospital) research programme including a stepped-wedge cluster-randomised trial
Background Patients who present acutely to hospital are often suspected to have bacterial infections and are prescribed antibiotics rapidly. Emerging diagnostic information then shows many of these prescriptions were, or no longer are, necessary, requiring prescribers to stop antibiotics: but there…
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Journal Article
Development and evaluation of strategies to reduce sedentary behaviour in stroke survivors and improve outcomes: the RECREATE research programme including pilot cRCT
Background There is increasing evidence that sedentary behaviour has a detrimental effect on health and well-being. At least 1.2 million people living in England have had a stroke, and longer-term outcomes are poor for many. Stroke survivors are particularly sedentary compared to age-matched…
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Journal Article
Penicillin allergy assessment pathway to improve antibiotic use: the ALABAMA intervention development, RCT, process and cost-effectiveness evaluation
Background People with penicillin allergy labels receive more antibiotics, different antibiotics and have worse health outcomes when compared to people without a penicillin allergy label. Objective To determine if a pre-emptive penicillin allergy assessment pathway can remove incorrect penicillin…
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Journal Article
Integrated therapist and online cognitive behavioural therapy for depression in primary care: the INTERACT research programme, including the INTERACT RCT
Background Cognitive–behavioural therapy is an effective treatment for depression. A key question is how to increase access. Engagement with cognitive–behavioural therapy-based computerised interventions is poor, and programmes are inflexible and impersonal. Innovative use of technology and…
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Journal Article
Rapid molecular diagnostics for pathogen identification in hospital-acquired and ventilator-associated pneumonia in critical care: INHALE research programme including RCT
Background Intensive care unit patients are vulnerable to hospital-acquired and ventilator-associated pneumonias. Immediate antibiotic therapy is warranted. Because: (1) many different bacterial species can be responsible and (2) it takes at least 2 days for conventional microbiological…