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Biochemistry Research International
Scopus
ISSN 2090-2247 · Wiley · 460 artikel di indeks
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Artikel Jurnal
Whey as an Environmental Issue and Its Possible Solutions: Its Utilization as Culture Medium to Produce L-Threonine Through E. coli in a Bioreactor
Whey, a by-product of the cheese manufacturing industry, represents one of the most abundant and polluting effluents in the global food industry. Despite traditionally being underutilized and often discarded, its rich nutrient profile, particularly protein and lactose, has increasingly sparked an…
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Artikel Jurnal
Therapeutic Effects of Gallic Acid and Alpha-Tocopherol on Adenine-Induced Chronic Kidney Disease in Male Wistar Rats
Chronic kidney disease (CKD) is a major health issue associated with oxidative stress and inflammation that leads to progressive renal damage. Natural antioxidants, gallic acid (GA) and alpha-tocopherol (AT), have gained attention for their strong free radical-scavenging, inflammation-reducing, and…
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Artikel Jurnal
Turning Agricultural Waste Into Enzymatic Treasure: Bromelain Stability in Pineapple Crown and Peel Waste From Subang District, Indonesia
Bromelain is one of the protease enzymes found in all parts of pineapple (Ananas comosus (L.) Merr.), including the crown and peel. This enzyme has been widely used in various fields of life, including the food industry, health, pharmaceuticals, and cosmetics. However, pineapple processing often…
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Artikel Jurnal
Comprehensive Analysis Reveals Potential Molecular Targets in Juvenile Dermatomyositis
Juvenile dermatomyositis (JDM) is a rare autoimmune disease primarily affecting children, characterized by muscle weakness and skin lesions. This study identifies 145 genes significantly associated with JDM through differential gene expression analysis, weighted gene coexpression network analysis…
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Artikel Jurnal
Noncatalytic Functions Are Required for MPO and PON1 in Modulating the Involvement of Monocytes and Endothelial Cells in Atherosclerosis
High-density lipoproteins (HDLs) are deeply implicated in atherosclerosis. HDL, myeloperoxidase (MPO), and paraoxonase-1 (PON1) form a functional ternary complex where PON1 partially inhibits the MPO activity, and MPO in turn partially inactivates PON1. The activity of MPO is dependent on the…
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Artikel Jurnal
NADPH-Related Enzymes and Cancer: Facts and Insights Into the Application of Immunohistochemistry
During tumorigenesis and metastasis, cancer cells initiate antioxidant defense mechanisms to prevent irreversible damage, thereby sustaining tumor growth. The functionality of reactive oxygen species (ROS)–scavenging proteins is dependent on nicotinamide adenine dinucleotide phosphate (NADPH)…
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Artikel Jurnal
Ligand-Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide-Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1
Type 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP-activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making…
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Artikel Jurnal
Pogostemon Cablin Aqueous Extract (PCAE) Induces Mitotic Delay by Downregulating CDC2/Cyclin B1 in TNBC Cells (MDA-MB-231)
Pogostemon cablin (PC) is a traditional medicinal herb with diverse pharmacological activities, including reported anticancer effects. However, its therapeutic potential in triple-negative breast cancer (TNBC) many unknowns remain. In this article, we investigated the antiproliferative activity of…
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Artikel Jurnal
Mitochondrial Dysfunction in MASLD: Evidence in Dietary Models and Potential Therapeutic Interventions
Metabolic dysfunction–associated steatotic liver disease (MASLD) is defined as the presence of excess triglyceride storage in the liver in the presence of at least one cardiometabolic risk factor. This term highlights the connection between fatty liver and metabolic dysfunction. Dietary factors…
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Artikel Jurnal
In Silico Pharmacokinetic Profile and Antimalarial Efficacy of 3-Chloro-4-(4-Chlorophenoxy)Aniline
Despite the urgent need for new therapies to treat multidrug-resistant virulent Plasmodium falciparum, many promising antimalarial candidates fail to progress to clinical use because their pharmacokinetic (PK) profile is poorly characterized. This study predicted the PK profile of a new compound…
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Protective Role of Rosmarinic Acid–Enriched Elsholtzia kachinensis Extract Against Oxidative and Inflammatory Stress in Human Trophoblasts Through the miR-138-5p/FOXC1 Pathway
Inflammation-induced dysregulation of microRNAs, particularly miR-138-5p, compromises trophoblast cell function and may contribute to pregnancy-related complications. While Elsholtzia species have been reported to possess therapeutic properties, the anti-inflammatory effects of Elsholtzia…
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Artikel Jurnal
Phytochemical Profile and Biological Activities of the Roots of Caesalpinia bonduc and the Aerial Part of Heliotropium indicum
This study investigates the phytochemical composition and biological activities of Heliotropium indicum and Caesalpinia bonduc, two medicinal plants widely used in traditional medicine in Benin. In ethnomedicinal practice, H. indicum is commonly prepared as decoctions or infusions of the aerial…
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Artikel Jurnal
6-Aminoflavone Inhibits Planktonic Growth, Disrupts Biofilm Architecture, and Regulates Quorum Sensing in Klebsiella pneumoniae
Antibiotic resistance has emerged as a major global health challenge, particularly in biofilm-forming pathogens that exhibit enhanced tolerance to antimicrobial therapies. K. pneumoniae, a multidrug-resistant pathogen, is a leading cause of hospital-acquired infections, including pneumonia…