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Journal of Genetic Engineering and Biotechnology
Scopus
ISSN 2090-5920 · Elsevier · 1.109 artikel di indeks
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Artikel Jurnal
Multinomial risk modeling of osteopenia and osteoporosis in Iraqi women: comparative contributions of osteoprotegerin and vitamin D3
Introduction: Vitamin D status is frequently low among Iraqi women, which may limit its discriminatory value for osteopenia (ON) and osteoporosis (OP). We evaluated the vitamin D axis (VD3, DBP, and VDR), osteoprotegerin (OPG), and endocrine regulators (estradiol [E2] and parathyroid hormone [PTH])…
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Artikel Jurnal
PI3K/AKT-associated fibroblast activation by native
Spidroins, the main structural protein constituents of spider silk, show excellent mechanical strength, durability and biocompatibility; therefore, they are potentially useful biomaterials for medical uses. Nevertheless, the molecular mechanisms that underlie their wound-healing activity are not…
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Computational evaluation of novel Schiff base compounds targeting
Background/Aim: Tuberculosis remains a major global health concern and continues to pose significant challenges to global public health. Key enzymes involved in mycobacterial cell wall biosynthesis, including DprE1, InhA, KasA, MmpL3, and LdtMt2, represent attractive therapeutic targets for…
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Green synthesis of polyherbal silver nanoparticles from
In this study, methanol concentrate of flowers and leaves of Cassia fistula and leaves of Manilkara zapota was used to obtain silver nanoparticles (AgNPs), followed by evaluation of wound healing potential in an animal model. The objective was to assess the overall wound-healing potential of the…
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Artikel Jurnal
Precision gene editing technology to modulate genes in oral diseases: Therapeutic applications and delivery strategies
Oral diseases represent a significant global health burden. Given the limited therapeutic efficacy of conventional mechanical interventions and antimicrobial treatments, there is a critical demand for targeted, precision therapies. Gene editing has emerged as a revolutionary approach that modifies…
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Design of a novel multi-epitope monovalent vaccine against Hantaan virus using an immunoinformatics approach
Hantaan virus is a well-known causative agent of Hemorrhagic Fever with Renal Syndrome (HFRS) which is distributed broadly in the Eastern Asia, particularly in Korea, Russia, and China. Despite its significance, no FDA-approved vaccine currently exists for this virus. Therefore, this study aimed to…
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Ancient mitochondrial DNA analysis of human remains in the era of next- generation sequencing
The analysis of ancient DNA (aDNA) has become important in recent years, providing new insights on human evolution and population history. Since the emergence of ancient DNA analysis in the mid-eighties, mitochondrial DNA (mtDNA) analysis has been an essential tool in paleogenomic research…
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Artikel Jurnal
Targeted delivery of siRNA against sodium-dependent phosphate co-transporter 2b (NPT2b) via functionalized mesoporous silica nanocarriers suppresses breast cancer cell growth
The sodium-dependent phosphate co-transporter 2b (NPT2b) plays an important role in maintaining phosphate homeostasis. In previous studies, we reported that high dietary inorganic phosphate consumption could increase NPT2b expression in mice while knockdown of NPT2b expression has been shown to…
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The molecular crosstalk between RECQ helicases and associated proteins in human genetic disorders
RECQ helicases involve a family of DNA unwinding enzymes, namely, RECQ1, Bloom syndrome protein, Werner syndrome protein, RECQL4, and RECQ5. These proteins interact with various proteins to form complexes and carry out a range of physiological functions. These genes are involved primarily in…
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Artikel Jurnal
Coumarins as modulators of protein–protein interactions: Computational insights, biological mechanisms, and translational perspectives
Coumarins are versatile bioactive scaffolds capable of interacting with diverse biomolecules, yet their potential role in modulating protein–protein complexes remains insufficiently characterized. Modern computational biology now enables rational exploration of how small molecules can influence…
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Artikel Jurnal
A computational workflow for proteome-wide analysis of sulfur-containing amino acid distribution in crop proteomes
Grain legumes are important sources of plant protein for human food and animal feed, but their nutritional quality is often limited by relatively low levels of sulfur-containing amino acids, particularly methionine. Despite their biological and nutritional importance, the distribution of methionine…
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Artikel Jurnal
Comparative genomic analysis of
Dengue fever poses an escalating global public health challenge, causing substantial morbidity and economic burden, particularly in tropical and subtropical regions. Wolbachia -mediated biocontrol has emerged as a cost-effective and environmentally sustainable strategy to suppress dengue…
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Artikel Jurnal
Feeding study of GM Rice bran (
Genetically modified (GM) rice ( Oryza sativa L) cv Rojolele overexpressing cry1B :: cry1Aa fusion genes, driven by the maize Ubiquitin promoter, has been developed to incorporate resistance trait against and to reduce loss due to the rice yellow stem borer (rice YSB, Scirpophaga incertulas…
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Artikel Jurnal
Deciphering differential mRNA and lncRNA expression profiles in response to PEG simulated drought stress in cucumber (Cucumis sativus L.)
Cucumber (Cucumis sativus L.), a vital fruit vegetable of the Cucurbitaceae family, originated in India ∼ 3000 years ago. It is widely used in the culinary, therapeutic, and cosmetic sectors. Cucumber cultivation is significantly impacted by drought stress, especially in arid and semi-arid regions…
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Artikel Jurnal
Taxonomic composition and predicted functional potential of the sputum bacterial microbiome in Iraqi patients with bronchiectasis using 16S rRNA gene amplicon sequencing
Bronchiectasis is a chronic respiratory disease characterized by persistent airway inflammation and recurrent infections. Although alterations in the airway microbiome have been reported, data from Middle Eastern populations remain limited. This study aimed to characterize the sputum bacterial…
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Artikel Jurnal
miR-34a and miR-223 as diagnostic biomarkers for the severity of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) and fibrosis, yet current non-invasive tools lack accuracy in distinguishing these stages. This study aimed to evaluate the circulating miR-34a and miR-223 as biomarkers for NAFLD staging…
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Artikel Jurnal
Network toxicology-aided identification of potential toxicological mechanisms of rhodamine B in ovarian cancer: Insights from transcriptomics, molecular docking, molecular dynamics simulations, and machine learning modeling
Ovarian cancer is the most lethal gynecological malignancy, accounting for disproportionate cancer-related mortality due to late-stage diagnosis and limited therapeutic options. Despite documented cytotoxicity, genotoxicity, hepatotoxicity, and reproductive toxicity of Rhodamine B, its toxic…
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Artikel Jurnal
Integrative multi-omics data fusion for potential biomarker prioritization in sulfur mustard exposed patients: A comparative study
Background: Sulfur mustard exposure causes severe and heterogeneous long-term health complications, yet the molecular determinants of disease severity remain incompletely understood. Integrative multi-omics approaches provide an opportunity to characterize coordinated biological responses and…
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Artikel Jurnal
In silico and in vitro drug repurposing strategy for targeting dopamine receptor D2 in colorectal Cancer treatment
Background: Colorectal cancer (CRC) remains a major global health burden due to its high incidence, mortality, and therapy resistance. Drug repurposing offers a promising approach to identify new treatments using approved drugs with known safety profiles. This study evaluates the potential of…
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Artikel Jurnal
Integrated prognostic framework for survival status, Cancer stages and time estimation in hepatocellular carcinoma using machine learning approaches
Current medical limitations in assessing cancer survival status, stage, and duration necessitate advancements beyond physical indicators and conventional diagnostic techniques. Improving the quality of patient treatment is an ongoing objective of the medical community. Accurate prediction of…
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