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Journal of Bio-X Research
Scopus
ISSN 2096-5672 · American Association for the Advancement of Science (AAAS) · 217 artikel di indeks
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Artikel Jurnal
Molecular Interactions between the Gut Microbiota and Insulin Signaling Pathways in Diabetes Mellitus
The prevalence of diabetes mellitus (DM) is increasing because of lifestyle factors including a sedentary lifestyle, poor food choices, and a genetic predisposition. DM has become a major concern in global health. Metabolism, immunological function, and insulin sensitivity are profoundly affected…
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Molecular and Microbial Remodeling in Response to Vestibular System Stress at Sea
The vestibular system contributes to our sense of proprioception and equilibrium, interacting with all body systems through projections to different brain areas. However, the molecular consequences of vestibular disturbance remain unclear. Here, we performed longitudinal multiomics analyses of…
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Microsponge-Mediated RNA Interference Silencing: A Novel Paradigm for Cancer Therapy
In cancer treatment, RNA interference (RNAi) has become a potent and targeted method for gene silencing. However, because of their instability, rapid disintegration, and low cellular absorption, small interfering RNAs (siRNAs) are still difficult to administer effectively. Recently, microsponges…
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The Role of Genetic Susceptibility in Prostate Cancer: Insights from Recent Studies
Prostate cancer is a serious global health issue, particularly among older males, with genetic susceptibility playing a critical role in its development and progression. This review synthesizes recent advances in understanding the genetic factors contributing to prostate cancer risk, including both…
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Novel pfk13 Gene Mutations Are Potentially Associated with Artemisinin Resistance in Plasmodium falciparum: A Clinical–Genetic Study
Background: Artemisinin-based combination therapies remain the first-line treatment for Plasmodium falciparum malaria. However, emerging resistance, often linked to mutations in the Kelch 13 (pfk13) gene, poses a substantial threat to malaria control efforts. This study investigated the molecular…
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Bioengineered 3D Liver Tumor Systems and Patient-Derived Organoids: A New Paradigm in Precision Oncology
Hepatocellular carcinoma, the most prevalent primary liver malignancy, remains a global health burden characterized by late-stage diagnosis, high recurrence rates, and limited systemic therapeutic options. Conventional 2-dimensional cell cultures and animal models fail to recapitulate the…
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Tumor Microenvironment in Pancreato-biliary Cancers: Crosstalk, Complexity, and Therapeutic Opportunities
Pancreato-biliary cancers, including pancreatic ductal adenocarcinoma, cholangiocarcinoma, and gallbladder cancer, develop through complex interactions within the tumor microenvironment. These tumors exhibit a dense stroma, immune suppression, and metabolic alterations that support growth and…
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Quantum-Resolved Photonic Editing of Endothelial Gene Regulation
Quantum-scale photomolecular genetic editing is emerging as a precise, noncontact strategy for modulating endothelial function through controlled light–matter interactions. This paradigm integrates photonics, quantum-scale energy transfer, and molecular genetics to regulate intracellular signaling…
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Performance–Efficiency Trade-off Analysis of Hybrid Deep Learning Models for Heart Disease Prediction
This study presents a systematic evaluation of classical machine learning, deep learning, and hybrid models for heart disease prediction using the University of California, Irvine dataset. A standardized framework with consistent preprocessing and 5-fold cross-validation was applied to ensure fair…
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Deformable Pathways: Exploring Transferosome Architecture and Functionality in Modern Drug Delivery Systems
Transferosomes are ultradeformable nanocarrier vesicles designed to enhance transdermal drug delivery. Their unique elasticity enables them to traverse the stratum corneum by adapting to microscopic pores, facilitating the transport of both low- and high-molecular-weight compounds that typically…
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Investigating FGM (PLA/UHMWPE/PVA) as an Artificial Hip Joint
This study proposes a hip implant designed with 6 layers of functionally graded polymers in graduated volumetric ratios, namely, polylactic acid (PLA) and ultra-high-molecular-weight polyethylene (UHMWPE). In addition, polyvinyl alcohol (PVA) was introduced as a porous PLA/UHMWPE/PVA inner layer…
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Potential Role of RORA in Osteosarcoma Pathogenesis: Evidence from Competing Endogenous RNA Network Analysis
Background: Osteosarcoma is a relatively rare malignant tumor characterized by high aggressiveness and poor prognosis. Traditional diagnostic approaches have several limitations, particularly in early detection and disease monitoring. In recent years, exosome-derived RNAs have attracted increasing…
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CERT1: A Novel Exploratory Nogo-A Binding Protein in Non-Small Cell Lung Cancer
Nogo-A is well known as an inhibitor of neurite outgrowth. Accumulating evidence suggests that it may also participate in the pathogenesis of non-small cell lung cancer (NSCLC), an aggressive malignancy with a 5-year survival rate of only 16.6%. However, the role of Nogo-A in NSCLC remains poorly…
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Three-Dimensional Printing of Smart Biomaterials: Emerging Strategies for Cancer Therapy and Neurological Repair
The convergence of 3-dimensional (3D) printing and smart biomaterials represents a transformative approach in biomedical engineering, particularly for oncology and neurology. Smart biomaterials, including stimuli-responsive polymers, nanocomposites, and hydrogels, offer unique advantages, such as…
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Genetic Overlap between Depression and PCOS: Causal Links and Shared Biological Pathways
Objective: To elucidate the complex causal relationship and shared genetic architecture between major depressive disorder (MDD) and polycystic ovary syndrome (PCOS) through large-scale genetic analyses across diverse populations. Data Sources: Data were obtained from European and East Asian…
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Ferroptosis in Human Disease: Molecular Circuitry, Cross-Disciplinary Regulatory Networks, and Novel Therapeutic Frontiers
Ferroptosis is a regulated form of cell death driven by iron-dependent phospholipid peroxidation. Since its formal description just over a decade ago, this process has emerged as a central link between fundamental cell biology and the pathophysiology of diverse clinical conditions, including…
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Tirzepatide: A Paradigm Shift in the Management of Type 2 Diabetes and Obesity
Type 2 diabetes mellitus and obesity represent intertwined chronic disorders that continue to escalate globally despite advances in pharmacotherapy. Current treatment strategies increasingly recognize the need to address both glycemic dysregulation and excess adiposity to meaningfully reduce…
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Rubidium Ionomics: Concept, Scope, and Methodological Framework
The rapid advancement of ionomics has substantially enhanced our understanding of ion homeostasis networks in living systems. However, systematic investigations of rubidium (Rb+) remain relatively limited. Accumulating evidence suggests that Rb+ not only is a chemical analog of potassium (K+) but…
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Fat Grafting Techniques in Regenerative Medicine: A Narrative Review
Background: Autologous adipose tissue transfer has evolved from simple volumetric augmentation to sophisticated regenerative procedures. Understanding the biological principles underlying fat grafting success is essential for optimal clinical outcomes. Objective: The aim to this study is o provide…
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Artikel Jurnal
mRNA-Based Nanomedicine in Cancer: Pharmacokinetic Innovations, Clinical Pharmacy Practice Integration, and the Future of Personalized Oncology
As a revolutionary breakthrough in cancer treatment, messenger RNA (mRNA)-based nanomedicine provides a versatile and programmable platform to elicit strong antitumor responses. In contrast to conventional treatments, mRNA can encode therapeutic proteins, immune activators, or tumor antigens…