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Journal of the National Cancer Center
Scopus
ISSN 2096-8663 · Elsevier · 257 articles in the index
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Journal Article
Genetic and epigenetic mechanisms underlying treatment-induced neuroendocrine prostate cancer
Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) characterized by unique pathological features and molecular changes, including the loss of androgen receptor (AR) activities and the gain of neuroendocrine gene expression…
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Journal Article
Temporal dynamics in cancer immunotherapy: the interplay between circadian rhythms, tumor microenvironment, and immune checkpoint blockade
The tumor microenvironment (TME) is a highly intricate and dynamic system composed of various cellular and non-cellular components, which plays a crucial role in regulating key biological processes such as tumor initiation, progression, and therapeutic response. Recent studies have uncovered a…
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Journal Article
Light-responsive nanotherapeutic carbon dots: a next generation tool for cancer phototherapy
Carbon dots (CDs) have emerged as promising nanomaterials in cancer phototherapy due to their unique optical properties, biocompatibility, and tunability. This review comprehensively examines the role of CDs in photodynamic therapy (PDT) and photothermal therapy (PTT), highlighting their mechanisms…
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Journal Article
Transcriptional and epigenetic reprogramming, lineage plasticity and therapy resistance in prostate cancer
Prostate cancer is the most commonly diagnosed and the second-leading cause of cancer-related mortality in men worldwide, especially in Western counties. Therapeutic resistance of prostate cancer remains a major challenge in modern oncology, necessitating new scientific understanding of the disease…
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Journal Article
Alterations in AR-FOXA1 signaling in prostate cancer progression and therapeutic resistance
The androgen receptor (AR) is instrumental in the onset and progression of prostate cancer (PCa), establishing androgen deprivation therapy (ADT) as the first-line treatment for metastatic disease. However, the effectiveness of ADT is commonly short-lived. Many patients eventually relapse and…
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Journal Article
Clinicopathologic, genetic and immune cell infiltration analysis of colorectal signet ring cell carcinoma with comparison to conventional adenocarcinoma
Objective: We sought to characterize the genomic and immune landscape of signet ring cell carcinoma (SRCC), a rare and aggressive subtype of colorectal cancer (CRC). Methods: Tissue samples and clinicopathological data were retrospectively analyzed from 37 SRCC and 172 conventional adenocarcinomas…
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Journal Article
Emerging therapies to overcome antiandrogen resistance and beyond in lethal prostate cancer
Prostate cancer remains the second most common malignancy among men worldwide, with treatment paradigms evolving dramatically over the last two decades. Despite the longstanding efficacy of androgen deprivation therapy (ADT) and its combination with next-generation androgen receptor (AR) signaling…
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Journal Article
Migrasomes program tissue microenvironment: from physiology to oncology, future perspectives in clinical advances
Cancer remains a critical global health challenge, necessitating an in-depth investigation into spatiotemporal dimensions. Migrasomes, a class of migration-dependent organelles that sequester spatiotemporal and biochemical cues, offer a previously overlooked pathway for microenvironmental…
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Journal Article
Global patterns of upper gastrointestinal cancer incidence by subtype and subsite in 2022: a population-based study
Objective: To provide an updated global assessment of esophageal and gastric cancers incidence by histological subtype and anatomical subsite. Methods: We utilized data from GLOBOCAN 2022 and Cancer Incidence in Five Continents Vol. XII (2013–2017) to estimate the incidence of esophageal cancer…
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Journal Article
Female underrepresentation and adverse events reporting biases in lung cancer clinical trials: a systematic review and meta-analysis
Objective: Despite regulatory initiatives to improve female representation in clinical trials, sex-based disparities persist, particularly in oncology. This is of concern given the rising burden of lung cancer in women. We aimed to quantify female representation in lung cancer clinical trials over…
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Journal Article
Extracellular vesicles in prostate cancer: current understanding and future perspectives
Exosomes are nanoscale, lipid bilayer extracellular vesicles (EVs) actively secreted by cells under both physiological and pathological conditions. As key mediators of intercellular communication, exosomes carry a diverse array of molecular cargo, including nucleic acids, proteins, lipids, and…
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Journal Article
Intrinsic and extrinsic regulators of cancer dormancy and awakening
Metastatic relapse is frequently driven by dormant disseminated tumor cells (DTCs) that previously evaded initial therapy, disseminated to distant tissues, entered into a non-proliferative state termed dormancy, and later reawakened to reinitiate active proliferation and the outgrowth of…