9.034 hasil
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mBio
Scopus
ISSN 2161-2129 · American Society for Microbiology · 9.034 artikel di indeks
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Artikel Jurnal
Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV-associated gastric cancer
ABSTRACT Epstein–Barr virus-associated gastric cancer (EBVaGC) accounts for ~9% to 10% of gastric cancers worldwide and is defined by a distinctive molecular profile, including extreme hypermethylation of the DNA. Targeting this aberrant methylation may be a potential therapeutic strategy. EBV+…
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Artikel Jurnal
An mRNA-encoded scFv antibody targeting the helix-α3 of HPV18 E7 oncoprotein as a novel antiviral strategy
ABSTRACT Despite the availability of prophylactic vaccines, human papillomavirus (HPV) infection remains the leading viral cause of cancer worldwide. The HPV E7 oncoprotein is a key factor in cancer progression by degrading host tumor suppressor proteins, thus offering a promising target for…
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Artikel Jurnal
Not all vaginal microbiomes are equal: functional context shapes immune landscapes
ABSTRACT Taxonomic classification alone fails to capture the ecological and functional diversity of vaginal microbiomes, particularly those dominated by Gardnerella species. Using the expanded VIRGO2 gene catalog, we developed the vaginal inference of subspecies and typing algorithm (VISTA), a…
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Artikel Jurnal
Genomic adaptation in group B Streptococcus following intrapartum antibiotic prophylaxis and childbirth
ABSTRACT Through vaginal colonization, group B Streptococcus (GBS) causes severe outcomes including neonatal sepsis and meningitis. Although intrapartum antibiotic prophylaxis (IAP) has reduced neonatal disease rates, GBS can persist in the genitourinary tract even after antibiotic administration…
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Artikel Jurnal
Legionella Lem26 functions as an ATG8-activated effector that inhibits host autophagy
ABSTRACT The intracellular pathogen Legionella pneumophila has evolved multiple effector proteins delivered into host cells by the Dot/Icm Type IVb secretion system that prevents recognition of the vacuole in which it resides by the host autophagy pathway. The number of effectors involved in this…
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Artikel Jurnal
A combination of proviral and antiviral roles of CD11c- and T-bet-expressing B cells defines parameters of chronic murine gammaherpesvirus infection
ABSTRACT Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection and are associated with the development of cancer and multiple sclerosis. Unlike other viral families, gammaherpesviruses selectively target B cells to establish chronic infection. Specifically…
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Artikel Jurnal
Fungal extracellular vesicles mediate conserved cross-species communication and immunomodulation
ABSTRACT Extracellular vesicles (EVs) play crucial roles in fungal communication and host immune modulation, representing potential therapeutic targets for fungal infections. This study investigated the role of fungal EVs in both intra- and interspecies communication, focusing on their effects on…
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Artikel Jurnal
The disputed identity of Pseudomonas putida KT2440: when taxonomists rename your favorite microbe
ABSTRACT Pseudomonas putida KT2440 has long served as a reference strain in environmental microbiology, biotechnology, and synthetic biology. Its recent taxonomic reclassification as P. alloputida, however, exemplifies the tensions generated by top-down renaming decisions that overlook…
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Artikel Jurnal
Staphylococcus species infected by a bacteriophage with a tail that is both curved and contractile
ABSTRACT Using a selective plating strategy for staphylococci, we surveyed the local community wastewater and purified 16 independent isolates representing the following seven species of Staphylococcus: S. cohnii, S. equorum, S. lentus, S. nepalensis, S. sciuri, S. shinii, and S. xylosus…
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Artikel Jurnal
An inducible CRISPRi system for phenotypic analysis of essential genes in Pseudomonas aeruginosa
ABSTRACT Precise and tunable genetic tools are essential for high-throughput functional genomics. To address this need in the important gram-negative pathogen Pseudomonas aeruginosa, we developed and characterized a tightly regulated CRISPR-interference (CRISPRi) system that enables precise and…
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Artikel Jurnal
The lipid language of tuberculosis: Mycobacterium tuberculosis surface molecules in host interaction and drug resistance
ABSTRACT Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a uniquely successful pathogen due in large part to its complex lipid-rich cell envelope. Comprising nearly 40% of its dry weight, Mtb lipids—such as mycolic acids, phthiocerol dimycocerosates (PDIM), trehalose…
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Artikel Jurnal
Divergent roles for complement components C3 and C4 in controlling Klebsiella pneumoniae gut colonization and systemic dissemination
ABSTRACT Klebsiella pneumoniae is an escalating public health threat driven by the emergence of antibiotic-resistant and hyper-encapsulated strains that spread systemically from the gut. The immune defenses preventing gut colonization and dissemination remain poorly defined. Here, we identify…
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Artikel Jurnal
The Mycobacterium tuberculosis ESX-5 secretion system enables carbon source utilization and growth in mice
ABSTRACT Mycobacterium tuberculosis uses several ESX type VII protein secretion systems for pathogenesis. M. tuberculosis ESX-5 is only partially characterized because it is essential for growth in standard lab culture conditions. To circumvent ESX-5 essentiality, we made an M. tuberculosis strain…
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Artikel Jurnal
Polar localization of putative phospholipid transporters in Escherichia coli
ABSTRACT The Gram-negative bacterial cell envelope comprises an outer membrane (OM) with an asymmetric arrangement of lipopolysaccharides and phospholipids (PLs), protecting them from both physical and chemical threats. To build the OM, PLs must be transported across the cell envelope; this process…
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Artikel Jurnal
Oropouche virus infects primary human intestinal organoids and is inhibited by type I and III interferon treatment
ABSTRACT Oropouche virus (OROV), a neglected arbovirus, has historically been considered a self-limiting infection associated with febrile illness. However, the recent surge in cases since late 2023 has been marked by atypical outcomes, highlighting its underestimated clinical impact…
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Artikel Jurnal
Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism
ABSTRACT Anaerobic metabolism of dietary choline to trimethylamine (TMA) by the human gut microbiome is a disease-associated pathway. The host’s impaired ability to oxidize TMA to trimethylamine-N-oxide (TMAO) results in trimethylaminuria (TMAU), while elevated serum TMAO levels have been…
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Artikel Jurnal
The Dp16 Down syndrome mouse model does not exhibit oral interferon-gammopathy or susceptibility to oral candidiasis
ABSTRACT Down syndrome, or Trisomy 21, is associated with excessive interferon (IFN) signaling and concomitant susceptibility to both autoimmunity and immunodeficiency. One of the many clinical phenotypes observed in people with Down syndrome is increased risk for oral candidiasis. Because oral…
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Artikel Jurnal
Inhibition of Neisseria gonorrhoeae complement-mediated killing during acute gonorrhea is dependent upon the IgG2:IgG3 antibody ratio
ABSTRACT Excessive binding of antibodies to the bacterial cell surface can paradoxically increase resistance of some Gram-negative pathogens to complement-mediated killing (CMK). We examined the CMK of 336 Neisseria gonorrhoeae isolates from 283 participants recruited to a clinical trial. Serum…
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Artikel Jurnal
Intestinal epithelial Tet2 deficiency reprograms the gut microbiota through bile acid metabolic alterations
ABSTRACT Epigenetic mechanisms are increasingly recognized as critical regulators of host–microbiota interactions, yet their specific roles in gut homeostasis remain elusive. Here, we demonstrate that intestinal epithelial-specific deletion of the DNA demethylase Tet2 leads to structural…
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