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The Journal of Prevention of Alzheimer's Disease
Scopus
ISSN 2274-5807 · Elsevier · 251 artikel di indeks
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Artikel Jurnal
Longitudinal changes in subcortical functional connectivity during Alzheimer’s disease progression
Human cognition and behavior rely on the integration of large-scale neural networks that connect the cerebral cortex and subcortical structures. Emerging evidence suggests that alterations in the functional connectivity (FC) between the cortical and subcortical regions in Alzheimer’s disease (AD)…
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The association of estimated glucose disposal rate with white matter hyperintensities: A large prospective cohort study
Background and objectives: Estimated glucose disposal rate (eGDR) is a novel and reliable marker of insulin resistance (IR), yet its association with white matter hyperintensities (WMH) remains unclear. This study investigates the relationship between eGDR and WMH in a cohort from the UK Biobank…
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Individualized prediction of transition from subjective cognitive decline to mild cognitive impairment based on multimodal MRI: a 10-year follow-up study
Background: Predicting the transition from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) is critical for dementia prevention. Objective: Comprehensive assessment of MRI-based macro-/micro-structural and functional brain changes in SCD to develop an individualized model…
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Cost-effectiveness of multimodal intervention for the prevention of dementia in Japan
Background: This analysis evaluated the potential cost-effectiveness of the Japan-Multimodal Intervention Trial for the prevention of dementia (J-MINT), targeting older adults with mild cognitive impairment (MCI) from a societal perspective. Methods: Using a time-dependent cohort state-transition…
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Synaptic toxicity of OGA inhibitors and the failure of ceperognastat
O-GlcNAcase inhibitors (OGAi) have emerged as a promising therapeutic strategy in Alzheimer’s disease (AD) by enhancing O-GlcNAcylation, which competes with tau phosphorylation and reduces tau aggregation. However, the Phase II clinical trial failure of ceperognastat, marked by accelerated…
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Association between plant-based diets and incident dementia: results from prospective cohort studies and a meta-analysis
Background: Plant-based diets are increasingly advocated for their health benefits, yet their associations with dementia risk remains inconclusive. We evaluated the associations between plant-based dietary patterns and dementia risk across three prospective cohorts and a meta-analysis. Methods…
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Plasma Aβ42/40 predicts progression from Aβ-amyloid negative to positive PET scans
Background: The agreement between plasma Aβ42/40 and Aβ positron emission tomography (PET) is approximately 75 %, with ∼85 % of discrepancies due to positive plasma but negative PET results. It is unclear whether this reflects Aβ changes in plasma before PET-detectable. Objectives: To assess the…
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A review of evidence supporting amyloid beta reduction as a surrogate endpoint in Alzheimer’s disease
Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disease driven by pathological depositions of proteins that accumulate over decades. Compelling genetic and neurobiological evidence suggests that amyloid accumulation in the brain initiates and drives early-stage AD. Measurement of…
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Soluble and plaque amyloid associations with peripheral glucose dysregulation modulated by tau pathology in Alzheimer’s disease
Background: Glucose metabolic dysfunction in Alzheimer’s disease (AD) has been reported to be associated with soluble amyloid-β oligomers (OAβ) and plaque amyloid. However, the potential modulatory role of tau pathology in these associations remains to be fully elucidated. Objectives: To…
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Artikel Jurnal
Hippocampal microstructure as a measure of cognitive resilience to tau PET burden in older adults
Background: Cognitive resilience, the ability to maintain better than expected cognitive function despite neuropathological burden, is a key contributor to clinical outcomes in Alzheimer’s disease (AD), though the underlying neurobiological mechanisms remain poorly understood. Objectives: To…
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Artikel Jurnal
Trajectory of cognitive decline before and after incident heart failure among older adults: A 20-Year, population-based, prospective cohort study
Background: The magnitude of cognitive change before and after incident heart failure (HF) is unclear. We investigated whether incident HF is associated with changes in cognitive function at the time of diagnosis and accelerated trajectory in cognitive decline in the subsequent years. Methods: We…
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Multi-omics integration reveals shared genetic architecture between metabolic markers and gray matter atrophy in Alzheimer’s Disease
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by widespread gray matter volume (GMV) reductions. Emerging evidence links glucose and lipid metabolic dysregulation to AD pathophysiology. However, the extent to which AD-related GMV alterations and…
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Iron dysregulation in cerebral small vessel disease: A quantitative susceptibility mapping study revealing spatial patterns and cognitive predictive value
Background: White matter hyperintensities (WMHs) represent a cardinal feature of cerebral small vessel disease (CSVD), yet iron dysregulation alterations within these lesions and their relationship to cognitive decline remains poorly understood. Objectives: To characterize iron dysregulation in WMH…
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Association of life’s simple 7 with cognitive function in a multi-ethnic cohort
Background and objectives: Multiple lifestyle and health factors could contribute to cognitive health, while not many studies examined the factors in a combined way, especially in Asian population. This study aims to examine the association of Life’s Simple 7 (LS7) with cognitive function and its…
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Artikel Jurnal
Systematic post-translational modification genome wide identifies therapeutic targets for Alzheimer’s disease: evidence from multi-cohort analysis
Background: The rapid increase in the incidence of Alzheimer’s disease (AD) has raised concerns, given its profound effects on both society and the economy. Despite extensive research efforts in this area, there are no existing treatments that have the ability to change the progression of the…
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Associations of plasma biomarkers with longitudinal co-pathologies in Alzheimer’s disease and cerebral small vessel disease comorbidity
Background: Plasma glial fibrillary acidic protein (GFAP), neurofilament light (NfL), phosphorylated tau217 (p-tau217), and the β-amyloid (Aβ) 42/40 ratio are emerging indicators of neuroinflammation, neurodegeneration, and AD-specific pathology, while their specific roles within Alzheimer’s…
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Artikel Jurnal
Association of neighborhood disadvantage with Alzheimer's disease pathology and the stability of blood-based biomarker performance
Background: Neighborhood-level factors, measured by the Area Deprivation Index (ADI), are linked to comorbidities of Alzheimer's disease and related dementias (ADRD). However, their direct association with AD neuropathology is unclear. The accessibility of blood-based biomarkers (BBMs) like…