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Kidney Diseases
Scopus
ISSN 2296-9381 · Karger Publishers · 343 articles in the index
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Journal Article
Epirubicin Ameliorates Kidney Fibrosis by Inhibiting B56δ-Mediated Lipid Generation
Introduction: Chronic kidney disease (CKD) presents a significant global health challenge, characterized by increased fibrosis and metabolic disturbances. B56δ, a regulatory B subunit of protein phosphatase 2A (PP2A), is known to mediate the activity of PP2Acα in regulating de novo lipid synthesis…
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Journal Article
Peripheral Blood Lymphocyte Subsets and Clinical Parameters in Patients Undergoing Renal Biopsy
Introduction Chronic kidney disease (CKD) is a major global health burden characterized by immune dysregulation. Peripheral blood lymphocyte subsets can reflect immune status across CKD pathologies. We evaluated associations between lymphocyte subsets and clinical parameters in patients undergoing…
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Journal Article
Interstitial Fibrosis and Tubular Atrophy as a Predictor of Renal Outcomes in Patients with Malignant Hypertension-Related Thrombotic Microangiopathy: A Multicentric Cohort Study
Introduction: Interstitial fibrosis and tubular atrophy (IFTA) are common pathological findings in patients with malignant hypertension (mHTN)-related thrombotic microangiopathy (TMA), but their predictive value for renal outcomes in this population remains unclear. Methods: This study included…
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Journal Article
Association of Body Composition-Related Indicators with Urinary Protein Levels and Proteinuria Remission in Patients with Primary Membranous Nephropathy
Introduction: To investigate the correlation between body composition-related indicators and urinary protein levels and proteinuria remission in patients with primary membranous nephropathy (PMN). Methods: This retrospective study enrolled patients with PMN who were diagnosed by renal biopsy…
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Journal Article
Single-Cell and Spatial Transcriptomics in Renal Injury and Fibrosis Research
Background: Kidney diseases, which are broadly classified into acute kidney injury (AKI) and chronic kidney disease (CKD), represent a significant and ongoing health burden in China and across the globe. AKI is a clinical syndrome marked by a rapid decline in renal function within 48 h due to…
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Journal Article
Unsupervised Clustering Identifies High-Risk Phenotypic Subgroup in Crescentic Glomerulonephritis Patients
Introduction: The current classification of crescentic glomerulonephritis (cGN) primarily focuses on renal outcomes; its ability to predict overall patient survival remains controversial. This study aims to develop a risk stratification system for overall survival and validate a renal risk score…
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Journal Article
Development and Validation of a Multivariable Nomogram Predictive of Kidney Function after Cardiopulmonary Resuscitation
Introduction: Kidney injury is an important manifestation of post-resuscitation syndrome and a significant factor leading to high mortality rates after cardiopulmonary resuscitation (CPR).This study aimed to develop and validate a multivariable nomogram to predict estimated glomerular filtration…
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Journal Article
Extracellular Vesicle-Based Urinary Proteomic Signatures Predict Remission and Relapse in Primary Membranous Nephropathy
Introduction: Primary membranous nephropathy (PMN) is one of the leading causes of nephrotic syndrome in adults, but reliable prognostic assessment tools remain limited. Although traditional clinical parameters and serum anti-PLA2R antibodies constitute cornerstones of prognosis assessment, they…
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Journal Article
Navigating Drug-Related Problems in Hemodialysis Patients across Dual Healthcare Systems: Bridging the Gaps for Optimal Medication Safety
Introduction: Drug-related problems (DRPs) are common in hemodialysis (HD) patients, but the impact of different healthcare delivery models on DRP prevalence, characteristics, and medication-related outcomes remains underexplored. This study aimed to investigate and compare DRP prevalence and…
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Journal Article
Combined Effects of Pulmonary Hypertension and Heart Valve Calcification on Cardiovascular Outcomes in Maintenance Hemodialysis Patients: A Risk Stratification Study Using Echocardiography
Introduction: Cardiovascular disease remains the leading cause of mortality in maintenance hemodialysis (MHD) patients. While both pulmonary hypertension (PH) and heart valve calcification (HVC) are established independent risk factors for adverse outcomes in this population, the synergistic effect…
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Journal Article
UCP2-Driven Fatty Acid Oxidation Promotes Macrophage M2 Polarization and Renal Fibrosis
Introduction: During renal fibrosis, macrophages play a crucial role in multiple processes, such as initiating inflammation, mediating tissue repair, and promoting interstitial fibrosis. Macrophage polarization is a key determinant of their functional properties. This study aimed to investigate the…
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Journal Article
Makorin Ring Finger Protein 1 Inhibits Cell Proliferation in Renal Angiomyolipoma via the ERK/MAPK Signaling Pathway
Introduction: Renal angiomyolipomas (AMLs) are clonal tumors formed by the abnormal differentiation of transformed renal progenitor cells. However, the cytogenetic and malignant transformations of renal AMLs require further investigation. Makorin ring finger protein 1 (MKRN1), a transcriptional…
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Journal Article
Prevalence and Risk Factors of Cardiovascular-Kidney-Metabolic Syndrome in Noncardiac Surgery Patients
Introduction: Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic disease that leads to multiple organ dysfunction and high rates of cardiovascular adverse outcomes. This cross-sectional study examines the prevalence and associated risk factors of different stages of CKM syndrome in…
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Journal Article
Decade-Long Trends in Chronic Kidney Disease-Mineral and Bone Disorder Target Achievement and Mortality Associations among Chinese Hemodialysis Patients: Insights from the China DOPPS Study
Introduction: Despite advancements in hemodialysis (HD) technology, mortality remains unacceptably high in end-stage kidney disease (ESKD) patients, with cardiovascular disease (CVD) as the leading cause. Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a critical contributor to CVD…
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Journal Article
A Phase 3 Study of Enarodustat in Chinese Patients Undergoing Peritoneal Dialysis for Treatment of Anemia: The ENAROPERA Study
Introduction: Anemia is a common complication in patients undergoing peritoneal dialysis (PD), significantly impacting quality of life and increasing cardiovascular risk. Enarodustat, an oral hypoxia-inducible factor-prolyl hydroxylase inhibitor, has been developed for the treatment of anemia in…
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Journal Article
Long-Term Outcomes in Patients with Renal Systemic Light Chain Amyloidosis
Introduction: Studies on the long-term outcomes of patients with predominant renal involvement and no significant extra-renal organ involvement in systemic light chain (AL) amyloidosis remain limited. Here we describe the outcomes of this population and examine the impact of the 1 year estimated…
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Journal Article
Additive Association of <italic>ABCG2</italic> rs4148155 and <italic>SLC22A12</italic> rs75786299 Polymorphisms with Hyperuricemia, Gout, and Nephrolithiasis: A Hospital-Based, Case-Control Study
Introduction: This study aimed to investigate the interaction between the ABCG2 rs4148155 and SLC22A12 rs75786299 variants and their association with incident gout and nephrolithiasis in the Taiwanese population to better understand the genetic loci regulating hyperuricemia and their contribution…
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Journal Article
Association between Antihistamine Use and Clinical Outcomes in Patients on Maintenance Hemodialysis
Introduction: H1 antihistamines are frequently used to treat pruritus in patients on dialysis, but their safety remains unclear. This study aimed to evaluate the effects of H1 antihistamine use on outcomes in patients undergoing maintenance hemodialysis (HD). Methods: This retrospective cohort…
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Journal Article
Predicting Chronic Kidney Disease in Type 2 Diabetes Using Natural Language Processing on Healthcare Data
Introduction: Persons with type 2 diabetes mellitus (T2DM) attending hospitals frequently experience major complications. We assessed the potential use of unstructured free-text data extracted from electronic health records (EHRs) using natural language processing (NLP) and machine learning (ML) to…
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Journal Article
Advances in Complement-Targeted Therapy for IgA Nephropathy
Background: IgA nephropathy (IgAN) is a common cause of renal failure among young people in China. The heterogeneity of the clinical and histological characteristics of this disease is predominant, which limits the development of targeted therapeutic drugs for different patient subgroups. In recent…