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Beni-Suef University Journal of Basic and Applied Sciences
Scopus
ISSN 2314-8535 · SpringerOpen · 1,087 articles in the index
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Journal Article
Urine analysis screening for crystalluria: evaluating prevalence and associated factors among school-aged children in beni-suef governorate in egypt. a cross-sectional study
Abstract Background Crystalluria is frequently found during the routine examination of urine sediments. Urinary screening is a valuable tool for the early detection of occult urinary abnormalities. Objectives This study aimed to estimate the prevalence of urinary crystalluria among school children…
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Journal Article
Integrated network pharmacology and molecular modeling approaches to reveal the anti-diabetic potential of phytochemicals from Zanthoxylum simulans
Abstract Background Zanthoxylum simulans, traditionally used for diabetes, lacks molecular mechanistic insights. This study integrates network pharmacology, molecular docking, ADMET profiling, 200-ns molecular dynamics, PCA, and FEL analyses to identify anti-diabetic phytochemicals from its fruit…
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Journal Article
Impact of endoplasmic reticulum (ER) stress on cellular functions and role of natural products as modulators
Abstract Background The endoplasmic reticulum (ER) is a dynamic and essential cell organelle involved in the synthesis and correct folding of secretory and membrane-bounded proteins, as well as in preserving intracellular Ca2+ equilibrium. Main body During cellular stress, the deposition of…
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Journal Article
Efficacy of platelet-rich fibrin and platelet-rich plasma in mitigating renal ischemia–reperfusion injury targeting the KIM-1 protein
Abstract Background Acute kidney injury often occurs after ischemia–reperfusion and is one of the main kidney diseases with high mortality. Accordingly, the aim of the current study was evaluated and compare the effectiveness of treatment with platelet-rich plasma (PRP) and platelet-rich fibrin…
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Journal Article
Protective effect of curcumin nanoparticles versus curcumin on gentamicin-induced nephrotoxicity in albino rats: histological and immunohistochemical study
Abstract Background and objectives Curcumin (Cur) and curcumin nanoparticles (Cur-NPs) have demonstrated protective effects against nephrotoxicity by reducing oxidative stress, inflammation, and cellular damage. This study aimed to evaluate and compare the efficacy of Cur-NPs with conventional Cur…
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Journal Article
Analytical wave solutions and bifurcation analysis for optical pulse propagation in resonant nonlinear Schrödinger equation using improved modified extended tanh function method
Abstract Background The study of optical pulse propagation through nonlinear media plays a fundamental role in the development of modern fiber-optic communication systems. Understanding the complex interaction between dispersion, cubic–quintic nonlinearities, resonance, and self-steepening effects…
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Journal Article
Muscone alleviated acetic acid-induced ulcerative colitis in mice through inhibiting NF-κB, IL-23/IL-17A axis, COX-2, and oxidative stress
Abstract Background Ulcerative colitis (UC) is an autoimmune condition distinguished by prolonged inflammation of the intestinal mucosa with fluctuating periods of relapse and remission. This research was designed to evaluate the prospective alleviative impacts of muscone…
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Journal Article
Repurposing gut microbiota modulators: insights into current and novel applications
Abstract Background Gut microbiota modulators (GMMs), including probiotics, prebiotics, and synbiotics, play a crucial role in maintaining gut health and influencing immunity, metabolism, and the gut–brain axis. Recently, these agents have gained interest for their potential to be repurposed beyond…
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Journal Article
Physico-mechanical reinforcement and antimicrobial efficiency of green-synthesized Ca/bentonite/chitosan nanocomposites
Abstract Background Bone tissue engineering necessitates the utilization of scaffolds that amalgamate biocompatibility, mechanical robustness, and antimicrobial properties to effectively address the challenges of regeneration and infection control. Natural polymers, such as chitosan, inherently…
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Journal Article
Solvability of m-product mixed non-linear functional integral equations
Abstract The purpose of this paper is devoted to establishing the existence of solutions for m-product non-linear functional integral equations with weakly singular and Riemann–Liouville integral terms. Our technique is based on Petryshyn’s theorem associated with the Hausdorff measure of…
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Journal Article
Protein malnutrition impairs skin elasticity in hairless mice by downregulating tropoelastin, fibrillin-1, and lysyl oxidase-like protein-1
Abstract Background Malnutrition is a known cause of skin disorders, but the genetic mechanisms linking it to dermal dysfunctions, particularly skin elasticity, are not fully understood. This study aimed to investigate how protein malnutrition (PM) affects the structure of the skin by reducing…
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Journal Article
Differential solvent extraction, qualitative phytochemical analysis, isolation of secondary metabolites, antioxidant, enzymes inhibitory, antimicrobial, and phytotoxic potentials of Jurinea himalaica R.R.Stewart
Abstract Background Jurinea himalaica, a medicinal plant native to the Western Himalayas, was comprehensively studied for its phytochemical composition and pharmacological potentials. Methods Qualitative phytochemical studies, polarity directed extraction of various fractions, and column…
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Journal Article
Evaluation of serum GDNF, TIMP4, and tPA levels in generalized anxiety disorder: a case–control study
Abstract Background Generalized anxiety disorder (GAD) is a psychological condition marked by persistent, overwhelming concern and intensified anxiety reactions that surpass situational stimuli, profoundly impacting social, vocational, and daily activities. Emerging evidence indicates that altered…
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Journal Article
PD-L1, CD8 + T-cell density, and CD105 angiogenesis: insights into the tumor microenvironment of hepatocellular carcinoma
Abstract Background and objectives Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The programmed death ligand 1 (PD-L1) immune checkpoint suppresses antitumor immunity in various malignancies. Endoglin (CD105), a transmembrane glycoprotein, is one of…
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Journal Article
Comprehensive evaluation of the anticancer activity of Egyptian bee venom (Apis mellifera): cytotoxic effects on diverse human cancer cell lines and tumor suppression in EAC mice
Abstract Background Bee venom (BV) contains a variety of bioactive agents, including peptides and enzymes, which possess anti-inflammatory, antioxidant, and antitumor properties. The current research aimed to investigate the in vitro cytotoxic effects of BV against human breast ductal carcinoma…
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Journal Article
Recovery of ovarian function by adipose mesenchymal stem cells and ovarian stem cells-derived exosomes in cyclophosphamide-induced ovarian insufficiency in rats
Abstract Background Infertility is a serious clinical condition that may have numerous causes; one of the most common causes of female infertility is chemotherapeutic-induced reduction of ovarian function and follicular count, which may lead to early menopause. This is known clinically as premature…
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Journal Article
Comparative evaluation of anti-inflammatory and antioxidant properties of Globularia alypum L. extracts and gels from Northern Tunisia
Abstract Background Globularia alypum L. is frequently used in traditional medicine to treat skin diseases and abscesses; however, there is no scientific evidence indicating the main organ of this plant responsible for its biological activity. Methods The present study aimed to assess the total…
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Journal Article
Exploration of soliton structures in (3+1)-dimensional generalized evolution nonlinear equation using an efficient integration scheme
Abstract Background Nonlinear wave equations in higher dimensions play a crucial role in describing complex behaviors in dispersive media such as optics, plasma, and fluid dynamics. However, deriving exact solutions for generalized multi-dimensional models remains difficult due to the strong…
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Journal Article
Engineered bimetallic Ag-Se nanozyme with multifunctional biomedical potential
Abstract Background Multidrug-resistant Gram-negative ESBL-producers including Escherichia coli and Klebsiella pneumoniae are becoming a critical obstacle in the treatment of chronic diabetic wounds. Biogenesis of nanoparticles with plant phytochemicals is a strong alternative antimicrobial…
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Journal Article
Synergistic effect of green synthesized zinc oxide nanoparticles coupled with various antibiotics against emerging multidrug resistant bacteria: characterization and therapeutic potentials evaluation
Abstract Background Antibiotic resistance is a worldwide health crisis that threatens public health systems and medical regimens, underscoring the urgent need for new antibacterial drugs. Hence, this study aimed to investigate the antibacterial efficacy of biosynthesized zinc oxide nanoparticles…
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