38 results
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Journal Article Full text
Seelische Gesundheit und psychische Belastungen von Kindern und Jugendlichen in der ersten Welle der COVID-19-Pandemie – Ergebnisse der COPSY-Studie
BACKGROUND: The drastic changes during the COVID-19 pandemic may have a negative impact on the psychological wellbeing of children and adolescents. OBJECTIVES: COPSY is the first national, representative German study to examine mental health and quality of life of children and adolescents during…
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Journal Article
The Diagnosis and Treatment of Age-Related Macular Degeneration
BACKGROUND: Age-related macular degeneration (AMD) is thought to cause approximately 9% of all cases of blindness worldwide. In Germany, half of all cases of blindness and high-grade visual impairment are due to AMD. In this review, the main risk factors, clinical manifestations, and treatments of…
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Journal Article
Ulcerative Colitis—Diagnostic and Therapeutic Algorithms
BACKGROUND: Ulcerative colitis is a chronic inflammatory bowel disease with an estimated 150 000 patients in Germany alone. METHODS: This review is based on publications about current diagnostic and therapeutic strategies for ulcerative colitis that were retrieved by a selective search in PubMed…
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Journal Article
The Diagnosis and Treatment of Glaucoma
BACKGROUND: Glaucoma is a group of chronically progressive disorders of the optic nerve. In this article, we present the epidemiology of and risk factors for glaucoma, as well as the diagnostic work-up and treatment options. METHODS: This review is based on pertinent publications retrieved by a…
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Journal Article Full text
COVID-19-Pandemie: Belastungen des medizinischen Personals
AIM: Review of studies on the psychological stress of healthcare workers caused by the COVID-19 pandemic. METHODS: A literature search of PubMed was performed using the terms "COVID-19", "stress", "mental health", "healthcare worker", "staff", "psychiatry". Quantitative studies (including letters…
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Journal Article Full text
A proposal for new diagnostic criteria for ALS
© 2020 The Authors. Published by Elsevier B.V. on behalf of International Federation of Clinical Neurophysiology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Book
Die Welt als Wille und Vorstellung
Die Welt als Wille und Vorstellung entstand in den Jahren 1814 bis 1818 in Dresden und erschien im Dezember 1818 mit der Jahreszahl 1819 bei Brockhaus in Leipzig. Unmittelbar nachdem das Hauptwerk erschienen war, habilitierte sich Schopenhauer mit seinem Buch an der Berliner Universitat und wurde…
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Journal Article Full text
Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
BACKGROUND: mutations. METHODS: mutations. In each dose cohort (20, 40, 60, or 100 mg), participants were randomly assigned in a 3:1 ratio to receive five doses of tofersen or placebo, administered intrathecally for 12 weeks. The primary outcomes were safety and pharmacokinetics. The secondary…
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Journal Article Full text
The Technology of Retail Central Bank Digital Currency
Central bank digital currencies (CBDCs) promise to provide cash-like safety and convenience for peer-to-peer payments. To do so, they must be resilient and accessible. They should also safeguard the user's privacy, while allowing for effective law enforcement. Different technical designs satisfy…
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Journal Article Full text
Psychosoziale Folgen von Quarantänemaßnahmen bei schwerwiegenden Coronavirus-Ausbrüchen: ein Rapid Review
OBJECTIVE: Review of the evidence on the psychosocial impact of quarantine measures during serious coronavirus outbreaks before COVID-19. Such information is highly relevant in regard to the COVID-19 pandemic. METHODS: Search of the MEDLINE database for relevant studies related to SARS-CoV and…
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Journal Article
Treatment of a Mouse Model of ALS by In Vivo Base Editing
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal disorder that can be caused by mutations in the superoxide dismutase 1 (SOD1) gene. Although ALS is currently incurable, CRISPR base editors hold the potential to treat the disease through their ability to create nonsense mutations…
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Book Full text
Future Skills
Im Buch wird der Wandel der Hochschulbildung weltweit analysiert, siebzehn Future Skills und vier Szenarien für die Hochschule der Zukunft präsentiert. Die NextSkills-Studie bietet über ein Multimethodendesign ein ganzheitliches bildungswissenschaftlich Konzept zukünftiger Hochschulbildung an.
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Journal Article
The Characteristics of 50 Hospitalized COVID-19 Patients With and Without ARDS
BACKGROUND: The type of pneumonia (coronavirus disease 2019, COVID-19) that is caused by the new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) is now spreading across the world in a pandemic. Many patients with COVID-19 were admitted to the University Hospital Aachen…
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Journal Article Full text
SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS
) were treated with a single intrathecal infusion of adeno-associated virus encoding a microRNA targeting SOD1. In Patient 1, SOD1 levels in spinal cord tissue as analyzed on autopsy were lower than corresponding levels in untreated patients with SOD1-mediated ALS and in healthy controls. Levels of…
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Book
PISA 2012. Fortschritte und Herausforderungen in Deutschland
PISA mißt die Leistungsfähigkeit von fünfzehnjährigen Schülerinnen und Schülern in den Bereichen Mathematik, Naturwissenschaften und Lesekompetenz. An der inzwischen fünften Erhebungsrunde beteiligten sich 65 Staaten. Der Schwerpunkt der Publikation liegt auf den Ergebnissen und Entwicklungen für…