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Artikel Jurnal Teks lengkap
Depauperate Avifauna in Plantations Compared to Forests and Exurban Areas
Native forests are shrinking worldwide, causing a loss of biological diversity. Our ability to prioritize forest conservation actions is hampered by a lack of information about the relative impacts of different types of forest loss on biodiversity. In particular, we lack rigorous comparisons of the…
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Multiplexed SNP Typing of Ancient DNA Clarifies the Origin of Andaman mtDNA Haplogroups amongst South Asian Tribal Populations
The issue of errors in genetic data sets is of growing concern, particularly in population genetics where whole genome mtDNA sequence data is coming under increased scrutiny. Multiplexed PCR reactions, combined with SNP typing, are currently under-exploited in this context, but have the potential…
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Artikel Jurnal Teks lengkap
Separation of Anti-Proliferation and Anti-Apoptotic Functions of Retinoblastoma Protein through Targeted Mutations of Its A/B Domain
Background: The human retinoblastoma susceptibility gene encodes a nuclear phosphoprotein RB, which is a negative regulator of cell proliferation. The growth suppression function of RB requires an evolutionarily conserved A/B domain that contains two distinct peptide-binding pockets. At the A/B…
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Hyperhomocysteinemia and Mortality after Coronary Artery Bypass Grafting
Background: The independent prognostic impact, as well as the possible causal role, of hyperhomocysteinemia (HHcy) in coronary artery disease (CAD) is controversial. No previous study specifically has addressed the relationship between HHcy and mortality after coronary artery bypass grafting (CABG)…
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Short and Long-Term Effects of hVEGF-A 165 in Cre-Activated Transgenic Mice
We have generated a transgenic mouse where hVEGF-A165 expression has been silenced with loxP-STOP fragment, and we used this model to study the effects of hVEGF-A165 over-expression in mice after systemic adenovirus mediated Cre-gene transfer. Unlike previous conventional transgenic models, this…
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Artikel Jurnal Teks lengkap
Modularity and Intrinsic Evolvability of Hsp90-Buffered Change
Hsp90 controls dramatic phenotypic transitions in a wide array of morphological features of many organisms. The genetic-background dependence of specific abnormalities and their response to laboratory selection suggested Hsp90 could be an ‘evolutionary capacitor’, allowing developmental variation…
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Artikel Jurnal Teks lengkap
GATA Transcription Factor Required for Immunity to Bacterial and Fungal Pathogens
In the past decade, Caenorhabditis elegans has been used to dissect several genetic pathways involved in immunity; however, little is known about transcription factors that regulate the expression of immune effectors. C. elegans does not appear to have a functional homolog of the key immune…
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Artikel Jurnal Teks lengkap
Non-Neutral Vegetation Dynamics
The neutral theory of biodiversity constitutes a reference null hypothesis for the interpretation of ecosystem dynamics and produces relatively simple analytical descriptions of basic system properties, which can be easily compared to observations. On the contrary, investigations in non-neutral…
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Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we…
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Artikel Jurnal Teks lengkap
Cross Species Association Examination of UCN3 and CRHR2 as Potential Pharmacological Targets for Antiobesity Drugs
Background: Obesity now constitutes a leading global public health problem. Studies have shown that insulin resistance affiliated with obesity is associated with intramyocellular lipid (IMCL) accumulation. Therefore, identification of genes associated with the phenotype would provide a clear target…
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Artikel Jurnal Teks lengkap
The Evolution of Mammalian Gene Families
Gene families are groups of homologous genes that are likely to have highly similar functions. Differences in family size due to lineage-specific gene duplication and gene loss may provide clues to the evolutionary forces that have shaped mammalian genomes. Here we analyze the gene families…
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Error Processing in Huntington's Disease
Background: Huntington's disease (HD) is a genetic disorder expressed by a degeneration of the basal ganglia inter alia accompanied with dopaminergic alterations. These dopaminergic alterations are related to genetic factors i.e., CAG-repeat expansion. The error (related) negativity (Ne/ERN), a…
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Artikel Jurnal Teks lengkap
Neural Substrate of Cold-Seeking Behavior in Endotoxin Shock
Systemic inflammation is a leading cause of hospital death. Mild systemic inflammation is accompanied by warmth-seeking behavior (and fever), whereas severe inflammation is associated with cold-seeking behavior (and hypothermia). Both behaviors are adaptive. Which brain structures mediate which…
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Artikel Jurnal Teks lengkap
Allometric Scaling of the Active Hematopoietic Stem Cell Pool across Mammals
Background: Many biological processes are characterized by allometric relations of the type Y = Y0Mb between an observable Y and body mass M, which pervade at multiple levels of organization. In what regards the hematopoietic stem cell pool, there is experimental evidence that the size of the…
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Artikel Jurnal Teks lengkap
Invasion and Persistence of a Selfish Gene in the Cnidaria
Background: Homing endonuclease genes (HEGs) are superfluous, but are capable of invading populations that mix alleles by biasing their inheritance patterns through gene conversion. One model suggests that their long-term persistence is achieved through recurrent invasion. This circumvents…
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Artikel Jurnal Teks lengkap
Expression of Transgenes Targeted to the Gt(ROSA)26Sor Locus Is Orientation Dependent
Background: Targeting transgenes to a chosen location in the genome has a number of advantages. A single copy of the DNA construct can be inserted by targeting into regions of chromatin that allow the desired developmental and tissue-specific expression of the transgene. Methodology: In order to…
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Artikel Jurnal Teks lengkap
Concentration of the Most-Cited Papers in the Scientific Literature: Analysis of Journal Ecosystems
Background: A minority of scientific journals publishes the majority of scientific papers and receives the majority of citations. The extent of concentration of the most influential articles is less well known. Methods/Principal Findings: The 100 most-cited papers in the last decade in each of 21…
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Establishing Clonal Cell Lines with Endothelial-Like Potential from CD9 hi , SSEA-1 − Cells in Embryonic Stem Cell-Derived Embryoid Bodies
Background: Differentiation of embryonic stem cells (ESCs) into specific cell types with minimal risk of teratoma formation could be efficiently directed by first reducing the differentiation potential of ESCs through the generation of clonal, self-renewing lineage-restricted stem cell lines…
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Artikel Jurnal Teks lengkap
A Single Basis for Developmental Buffering of Drosophila Wing Shape
The nature of developmental buffering processes has been debated extensively, based on both theoretical reasoning and empirical studies. In particular, controversy has focused on the question of whether distinct processes are responsible for canalization, the buffering against environmental or…
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Artikel Jurnal Teks lengkap
Molecular Adaptation during Adaptive Radiation in the Hawaiian Endemic Genus Schiedea
Background: “Explosive” adaptive radiations on islands remain one of the most puzzling evolutionary phenomena. The rate of phenotypic and ecological adaptations is extremely fast during such events, suggesting that many genes may be under fairly strong selection. However, no evidence for adaptation…
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