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Artikel Jurnal Teks lengkap
Multidimensional analysis of clinical pharmacist intervention impact on hospital length of stay in pulmonary tuberculosis: a random forest-driven retrospective study
The optimization of hospital length of stay (LOS) for tuberculosis (TB) patients remains a critical challenge in healthcare management. This study employs advanced machine learning (ML) techniques to analyze the impact of clinical pharmacist intervention on LOS and identify key predictive factors…
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Tiger stripe: an innocuous Doppler artifact
BACKGROUND: Tiger stripes, parallel bands within regurgitant Doppler spectra, are often ascribed to oscillating intracardiac structures. Their frequency and clinical relevance are unclear. METHODS: We retrospectively reviewed 4,567 transthoracic echocardiograms (TTEs) in adults between 18 and 65…
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Peri-arrest ventilation with positive end-expiratory-pressure vs. zero end-expiratory-pressure in out-of-hospital-cardiac-arrest (PerAVent)—a prospective, cluster-randomized multicenter trial
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation…
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Dynamic testing of cortisol in consecutive patients with suspected adrenal disorders: a comparison of Elecsys Cortisol II and LC-MS/MS
GRAPHICAL ABSTRACT: [Image: see text] ABSTRACT: The increased detection of adrenal incidentalomas and drug-induced adrenal insufficiency increases the demand for cortisol testing. While liquid chromatography–tandem mass spectrometry (LC-MS/MS) and dynamic testing remain the gold standard, more…
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A systematic review of ipilimumab-induced hypophysitis
GRAPHICAL ABSTRACT: [Image: see text] ABSTRACT: BACKGROUND: Ipilimumab, a CTLA-4-targeting monoclonal antibody, enhances T-cell activation and improves outcomes in various malignancies. However, it is associated with immune-related adverse events (IRAEs), including hypophysitis – a rare but…
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NMR-based metabolomics in a clinical cohort: deciphering the metabolic characteristics of gout with the dampness-heat syndrome and elucidate the efficacy of Simiao Pill
BACKGROUND: Gout is an inflammatory arthritis caused by purine metabolism disorders. The gout with the dampness-heat syndrome (GDHS) is a common Traditional Chinese Medicine (TCM) syndrome in this kind of disease, yet its modern scientific basis remains poorly understood. Simiao Pill (SMP), a…
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Critical reflections on post-pandemic dengue surveillance in Quezon city, Philippines
This correspondence critically reflects on the recent article by Medina et al. (2025), “Pre- and post-COVID-19 pandemic identification of dengue hotspots and exploration of determinants in Quezon City.” While acknowledging the study’s timely contribution to understanding dengue dynamics in an urban…
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Fatty acid metabolism: opportunities and challenges of traditional Chinese medicine in the treatment of renal fibrosis
Renal fibrosis (RF), as a critical pathological process in the progression of chronic kidney disease (CKD) to end-stage renal disease, currently lacks clear and effective reversal measures. Disordered fatty acid metabolism is highly involved in this process. Studies have revealed that molecular…
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Force coordination distinguishes epithelial and mesenchymal modes of collective chemotaxis
Collective cell migration is essential for development and tissue homeostasis and plays a central role in pathological processes such as tumor metastasis. While extensively studied in epithelial cells, collective migration is also observed in mesenchymal cells, though the mechanistic similarities…
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Classificação e caracterização da exposição de pescadores(as) artesanais expostos(as) ao derramamento de petróleo em Pernambuco, Brasil
This study sought to classify and characterize the exposure of artisanal fishers from Pernambuco, Brazil, to oil during disaster-crime that took place on the Northeast coast of the country in 2019. A cross-sectional epidemiological study was conducted involving interviews with 1,259 artisanal…
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Clinical outcomes of bovine pericardial tissue patch grafting for surgical correction of Peyronie’s disease: a prospective single-center case series
BACKGROUND: Surgical correction of Peyronie’s disease often requires grafting techniques to restore penile anatomy and function. The bovine pericardial patch is a promising biomaterial due to its strength, elasticity, and biocompatibility. This study evaluates the safety, handling, and clinical…
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Oral health and background characteristics in a prison population: the PriOH study
OBJECTIVES: The Nordic welfare state aims for social security and equality. However, incarcerated people often face vulnerable situations impacting oral health. This study describes oral health and background characteristics of incarcerated people in Norway and explored differences between Nordic…
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The expression profile and clinical relevance of miR-125a-5p in individuals with chronic periodontitis
BACKGROUND: Chronic periodontitis is a prevalent inflammatory disease, and miR-125a-5p’s role in its pathogenesis remains unclear. OBJECTIVE: We examined the clinical significance and mechanisms of miR-125a-5p in chronic periodontitis by testing two hypotheses: (1) miR-125a-5p expression is altered…
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Soil fertility and rhizosphere microbiome affecting hydroxysafflor yellow A accumulation in safflower
INTRODUCTION: Safflower (Carthamus tinctorius L.) is a prized medicinal species whose therapeutic value hinges on the abundance of bioactive metabolites. Accumulation of these metabolites are influenced by a range of environmental and edaphic factors, including soil physicochemical parameters…
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Supplementation with commercially available probiotic bacterial strains reduces fat accumulation in Caenorhabditis elegans by regulating the lipid metabolism pathway
Enterococcus faecium T-110 (EFT110), Bacillus subtilis TO-A (BSTOA), and Clostridium butyricum TO-A (CBTOA) are probiotic bacteria used as supplements to improve intestinal symptoms in humans, chickens, pigs, cattle, and fish. However, their effects on hosts remain unclear. Our previous study…
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Complete Genome Sequence of Gordonia phage RedRaider
We isolated and annotated a novel bacteriophage, RedRaider, on Gordonia terrae 3612. Annotation revealed genome features typical of cluster CR3 phages with the putative lysin A function encoded in two gene products, a protease C39 domain and a glycosyl hydrolase domain, and lysin B encoded distally…
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Deletion of Rspo1 or Rspo3 in the mesenchyme does not affect Wolffian duct maintenance or morphogenesis.
Secreted proteins, R-Spondin 1 (RSPO1) and R-Spondin 3 (RSPO3), potentiate WNT/β-catenin signaling that play critical roles in reproductive organ development. However, the functional significance of RSPO1 and RSPO3 in Wolffian duct development remains undefined. In this report, we demonstrated…
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Genome Sequence of Actinobacteriophage LilTerminator, Isolated From Microbacterium foliorum on Jekyll Island, Georgia
Actinobacteriophage LilTerminator was isolated from soil collected from Jekyll Island, Georgia, using Microbacterium foliorum NRRL B-24224 as the host. The genome of this phage is 39,963 bp, circularly permuted, and contains 62 predicted genes, including one tRNA gene. Based on gene content…
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