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Orthognathic surgery and postoperative nausea and vomiting: An 11-year retrospective observational study
Orthognathic surgery (OGS) is now widely performed, and postoperative nausea and vomiting (PONV) remains a common complication. Gastric decompression using a nasogastric tube (NT) is generally considered an effective prophylactic measure. In this retrospective observational study, we reviewed 667…
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Depressive and anxiety symptomatology among caregivers of children 0-3 years in Nairobi City County: Community-based prevalence study
Caregivers of young children in low-resource urban settings face multiple stressors, which can affect their mental health. There is limited population-based evidence on the prevalence and correlates of depression and anxiety among caregivers of young children in these contexts. This study assessed…
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Evaluation of AT121 versus morphine on cortical neurons electrophysiology and dopamine concentrations in hippocampal cells
In order to achieve pain relief without associated tolerance and dependence risks of general opioids like morphine, researchers have designed AT121 as potent safe alternative. In this study, we evaluated the analgesic and neurochemistry effects of AT121, a bifunctional partial agonist at Mu and…
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Identification and clinical implications of immune-related hub genes in psoriasis
Background: Psoriasis, a chronic inflammatory skin disease affecting 2–3% of the global population, is driven by dysregulated immune responses. Despite advancements in biologic therapies, treatment challenges persist due to high recurrence rates. This study aimed to identify immune-related hub…
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Beyond individual markers: Prognostic value of the combined CEA/PNI score in metastatic colorectal cancer as a predictor of survival
Malnutrition and systemic inflammation significantly worsen the prognosis of oncology patients, contributing to 10–20% of cancer-related deaths. While the Carcinoembryonic Antigen (CEA) reflects tumor burden, the Prognostic Nutritional Index (PNI) captures nutritional and immune status. This study…
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An AI-based chatbot to support health-related social needs among pediatric primary care population: Protocol for a pilot randomized controlled trial
Unmet health-related social needs (HRSNs) are major drivers of poor health outcomes in early childhood. Children with unmet HRSNs are at greater risk for developmental delays, caregiver stress, and increased healthcare utilization, yet current screening approaches in pediatric primary care are…
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Healthcare built environment and behavioural and physiological indicators of stress responses in autism spectrum disorder: Protocol for a mixed-methods systematic review
Introduction: Autistic populations are more likely to need healthcare (HC) services due to co-occurring mental health issues, including anxiety and attention-deficit hyperactivity disorders. One of the most significant barriers to delivering optimal medical procedures in autism spectrum disorder…
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The association between bullying and toothache in Brazilian students: An analysis of the Brazilian National Student Health Survey
This study analyzed the association between self-perceived bullying and self-reported toothache among Brazilian students and evaluated the moderating role of school-based health actions, including participation in the School Health Program, oral health promotion, and bullying prevention. A…
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Computational investigation of African natural products as Helicobacter pylori shikimate kinase inhibitors
Helicobacter pylori is one of the most prevalent bacteria, infecting more than 40% of the world’s population. Rising antibiotic resistance has created an urgent need for the discovery of novel therapeutic agents. One of the potent drug targets for H. pylori is shikimic acid pathway, which…
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Forest tree diversity is dependent on both mycorrhizal type and scale
The diversity of forest communities is intricately shaped by the mycorrhizal associations that trees form with soil fungi. Mycorrhizae, which are mutualistic relationships between fungi and plants, play pivotal roles in nutrient exchange and tree survival. This review explores how the type of…
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Genetic testing in individuals with extreme HDL-C levels: Diagnostic yield and clinical implications from the Tromsø Study
Aim: This study aimed to assess the prevalence of genetic variants responsible for extreme levels of high-density lipoprotein cholesterol (HDL-C) and evaluate the adequacy of current thresholds for genetic testing of HDL-related dyslipidemia. Methods: Using data from the Tromsø Study, a…
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Who would take part in a pandemic preparedness cohort study? The role of vaccine-related affective polarisation: Cross-sectional survey
Cohort studies are an important tool for public health research about emerging infectious diseases. Willingness to participate in research is associated with multiple factors. Little is known about the role of people’s feelings, especially in the aftermath of the COVID-19 pandemic. Affective…
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Impact of complex medication regimens on adherence in multimorbidity senior citizen – Study from Nepal
Background: Elderly individuals often experience multiple comorbidities, requiring the use of several pharmacological therapies to improve their quality of life and extend life expectancy. However, medication non-adherence is a common issue in this population, potentially leading to significant…
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Popularizing health education, building public health facilities or regular screening? How to prevent schistosomiasis more effectively in African children
Due to the lack of safe drinking water and public health facilities, as well as the low popularity of health education, schistosomiasis is a prominent problem in African children. Considering that the process of schistosomiasis prevention in African children is dynamic and continuous, this paper…
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The effect of health on refugees’ labor market integration: Evidence from a natural experiment in Germany
This paper analyzes the role of health for refugees’ integration into host countries’ labor markets. We exploit the quasi-random dispersal policies of refugees across regions in Germany to analyze the causal effect of health on employment. Based on regional and temporal heterogeneity in a policy…
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Which turtle should I study? Uneven distribution of research effort across Testudines species
Understanding why some species are more often studied than others can provide valuable information on potential biases that research effort discrepancies can cause and help to direct future research to mitigate these biases. Turtles form an order of reptiles in which the majority of species (67%)…
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Insecticidal and knockdown resistance status of Anopheles gambiae s.l (Diptera: Culicidae) to pyrethroid and organophosphate insecticides in Osun State, Nigeria
Insecticide resistance in malaria vectors remains a global public health problem; however, little is known about resistance levels in Osun State, despite relatively high rates of malaria and distribution of insecticide-treated nets in the area. This study evaluates the resistance status of adult…
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Analysis of ovarian cancer immune cell profile identifies immunosuppressive states associated with adverse clinical attributes and survival times
The ovarian tumor microenvironment (TME) is highly immunosuppressive, limiting immunotherapy effectiveness. We investigated whether the composition, ratios, and polarization of infiltrating immune cells provide prognostic value in ovarian cancer (OC). Our analysis revealed that immune ratios…
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Deciphering the molecular network of Trichostatin A in regulating Alzheimer’s disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation
Background: Histone deacetylases (HDACs) regulate neuroprotection; however, Trichostatin A (TSA), an HDAC inhibitor, lacks clear molecular mechanisms and core targets in Alzheimer’s disease (AD), limiting clinical translation. This study aimed to decipher TSA’s AD-regulating network, screen core…
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Academic workload and lifestyle predict emotional well-being among university students in the United Arab Emirates: A cross-sectional study
Background: Stress is a prevalent issue among university students and is linked to adverse academic and emotional outcomes. While research emphasizes the roles of resilience, personality traits, and psychosocial factors, most studies are drawn from North American and European contexts. Objectives…
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