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Artikel Jurnal Teks lengkap
Protective role of fatty acid oxidation against epithelial barrier dysfunction in allergic asthma
BACKGROUND: Fatty acid oxidation (FAO) is implicated in lung diseases, but its role in bronchial asthma is not fully understood. We investigated its effect on airway epithelial barrier integrity. METHODS: Using a house dust mite (HDM)-induced murine asthma model and HDM, IL-4, IL-13, or TNF-α…
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A Retrospective Long-Term Follow-Up of the Randomized Study: Total Endoscopic Ablation of Patients With Long-Standing Persistent Atrial Fibrillation
OBJECTIVES: Minimally invasive surgical ablation for atrial fibrillation is an alternative to catheter ablation. Achieving a lasting sinus rhythm in long-standing persistent atrial fibrillation is challenging, and long-term data after surgery are limited. In 2016, we published a randomized trial…
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Viable appendico-ileal knotting resulting in acute small bowel obstruction: a case report from Ethiopia
Appendico-ileal knotting is a rare cause of small bowel obstruction, usually complicated by strangulation and resection of bowel. A 32-year-old woman presented with 24-hour abdominal pain, bilious vomiting, distension, and obstipation. Visible peristalsis was noted on physical examination; a…
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A Type-Entry-Malperfusion-Based Propensity Score Matched Analysis Depending on Surgical Expertise in Patients Without Malperfusion Undergoing Surgery for Acute Type A Aortic Dissection
OBJECTIVES: This study investigates differences in short- and mid-term outcomes in patients without malperfusion undergoing surgery for acute type A aortic dissection between specialized aortic surgeons and non-aortic surgeons. METHODS: Patients who underwent surgery for acute type A aortic…
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Commissural Prolapse: Combining the Best From Two Aortic Valve Repair Techniques
Aortic valve commissural avulsion is an exceptionally rare and often underdiagnosed cause of aortic regurgitation. We report a 30-year-old male with severe chronic aortic regurgitation and a mildly dilated aortic root, in whom intraoperative inspection revealed spontaneous avulsion of the…
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Advancements in development of novel class of HIV protease inhibitors
BACKGROUND: Protease (PR) inhibitors (PIs) are widely regarded as the most significant agents in the treatment of human immunodeficiency virus (HIV) and have been instrumental in the success of highly active antiretroviral therapy (HAART). The PR enzyme is essential for the viral life cycle, as it…
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Assessment of patient-reported symptom and psychological distress after neoadjuvant chemo-immunotherapy and lung resection for non-small cell lung cancer
OBJECTIVES: Neoadjuvant chemo-immunotherapy is associated with oncologic benefits in patients undergoing resection for locally advanced non-small cell lung cancer (NSCLC). We assessed patient-reported physical and psychological symptoms following neoadjuvant chemo-immunotherapy and surgery compared…
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Establishing global standards on wearable technology for measuring mobility in ageing populations: an international consensus exercise
BACKGROUND: Mobility, defined as movement in all its forms, is a hallmark of healthy ageing. As wearable technologies become increasingly integrated into population health surveillance and ageing research, the absence of standardised terminology, measurement protocols and reporting practices…
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Robotic-assisted radical cystoprostatectomy and intracorporeal ileal conduit formation in a patient with prior total colectomy and J-pouch
We present the first reported case of robotic-assisted radical cystoprostatectomy and ileal conduit formation in a patient with prior total colectomy and J-pouch. The anatomy posed significant technical risk due to end artery pouch perfusion and changes in the posterior plane. Intraoperative…
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Charting immune variation through genetics and single-cell genomics
Large-scale single-cell genomics projects have revolutionized our understanding of human immune variation. Yet most studies to date have been Eurocentric, limited in cell-type resolution, or restricted to a single data modality. The newly published Chinese Immune Multi-Omics Atlas helps address…
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Global patterns and determinants of household medicine storage and disposal: a systematic review and meta-analysis
BACKGROUND: Improper storage and disposal of unused and expired medicines at home have become a global challenge, creating significant hazards to public health and the environment. This systematic review aimed to explore the prevalence of proper storage and disposal of medicines and to examine…
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Investigation of exercise-mimetic bioactive molecules as modulators of MMP activity and expression in cancer cells
Matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, are directly involved in the degradation of the extracellular matrix preceding uncontrolled cancer growth and metastasis. For these reasons, MMPs are considered key therapeutic targets in the development of cancer treatments…
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Prevalence of Obstructive Sleep Apnea and Adherence to CPAP for TAXI Drivers
We investigated the effects of Continuous Positive Airway Pressure (CPAP) on blood pressure (BP) and vigilance in taxi drivers with obstructive sleep apnea (OSA). This pilot study recruited taxi drivers aged ≥60 years to undergo polysomnography. Those diagnosed with OSA underwent 6 months of CPAP…
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Parental Knowledge and Attitudes Toward Emergency Management of Dental Trauma in Children: A Cross-Sectional Croatian Study
Aim: Traumatic dental injuries (TDI) in children are a common but often underestimated emergency. Parental knowledge and timely response are crucial for successful treatment. This study aimed to evaluate parental knowledge, experiences, and awareness regarding dental trauma management and the use…
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Relevance and Feasibility of a “Geriatric Delirium Pass” for Older Patients with Elective Surgeries: Findings from a Multi-Methods Study
Background/Objectives: Postoperative Delirium (POD) is a frequent complication in older patients undergoing elective surgery. Although multicomponent interventions are effective, deficits in interdisciplinary communication and intersectoral collaboration persist. This study developed and evaluated…
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Cardiovascular Disease Burden in Rural Central Asia: A Systematic Review of Epidemiological Trends and Mortality Patterns
Background/Objectives: Cardiovascular diseases (CVDs) remain a leading cause of mortality worldwide, with a particularly high burden in Central Asian countries. Despite ongoing urbanization, rural populations constitute a significant demographic in this region, yet epidemiological data stratified…
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Paraneoplastic Neuro-Ophthalmologic Symptoms as Initial Manifestation of Hodgkin Lymphoma
Background and Clinical Significance: Patients with Hodgkin lymphoma (HL) often present with lymphadenopathy, biochemical inflammation, and constitutional symptoms, but may experience symptoms from extra-nodal organs. Symptoms are caused by either lymphoma or a paraneoplastic phenomenon but overt…
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Assessment of Temporomandibular Disorders, Oral Health Status, Knowledge and Hygiene Behaviours Among Athletes in Croatia: A Cross-Sectional Study
Aim: This study aimed to assess self-reported oral and orofacial health, hygiene habits, and oral health knowledge among Croatian athletes, and to determine factors influencing that knowledge. Differences between contact and non-contact sports, as well as the occurrence of dental trauma and…
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Impact of Social Determinants of Health in the Treatment of Closed Nasal Bone Fractures
Study Design: Retrospective cohort study. Objective: To determine the association of social determinants of health with rates of closed nasal bone reduction. Methods: A retrospective analysis of the National Trauma Data Bank (NTDB) from 2011 to 2019 was performed, including only adult patients with…
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