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Artikel Jurnal Teks lengkap
Parent Experience and Attitudes Towards Newborn Bloodspot Screening in Ireland
The aim of the evaluation was to gather information on parents’ experiences and attitudes towards the Irish National Newborn Bloodspot Screening Programme (NNBSP). An interviewer-administered survey was completed by 151 parents whose babies underwent newborn bloodspot screening (NBS) between 2023…
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Leveraging Artificial Intelligence-Based Applications to Remove Disruptive Factors from Pharmaceutical Care: A Quantitative Study in Eastern Romania
Artificial Intelligence (AI) has increasingly contributed to advancements in pharmaceutical practice, particularly by enhancing the pharmacist–patient relationship and improving medication adherence. This quantitative, descriptive, cross-sectional study investigated Eastern Romanian pharmacists’…
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Integrative Sequencing and Proteogenomic Approaches to Intratumoral Heterogeneity in Cholangiocarcinoma: Implications for Precision Diagnosis and Therapy
Cholangiocarcinoma (CCA) is a highly aggressive cancer of the biliary tract, distinguished by significant intratumoral heterogeneity (ITH), which contributes to therapy resistance and unfavorable clinical outcomes. Traditional genome profiling has revealed recurring driver changes in CCA; yet…
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Tumor Infiltrating Lymphocytes in Cutaneous Squamous Cell Carcinoma—A Systematic Review
Cutaneous squamous cell carcinoma (cSCC) is an immunogenic malignancy with variable immune infiltration and inconsistent responses to checkpoint blockade. Tumor-infiltrating lymphocytes (TILs) influence tumor progression and therapeutic outcome, yet their phenotypic and functional diversity across…
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A Method for Assessing Week-Long Cortisol Output Using a Continuously Worn Sweat Patch
Although sample matrices are available for assessing cortisol output over hours/days (serum, saliva, or urine) or months (hair or nails), there is no current method for measuring integrated cortisol output over a period of 1 week. Therefore, the primary aim of this study was to develop and validate…
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Autoantibodies as Precision Tools in Connective Tissue Diseases: From Epiphenomenon to Endophenotype
Autoantibodies have long been regarded as passive reflections of immune dysregulation in connective tissue diseases (CTDs). Recent advances in systems immunology and molecular pathology have fundamentally redefined them as active molecular fingerprints that delineate distinct disease endophenotypes…
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Circulating Lipid Peroxides Associate with More Aggressive Tumor Phenotypes and Increased Risks of Recurrence and Mortality in Breast Cancer Patients
Background/Objectives: Breast cancer is the most common neoplasm among women and remains the leading cause of cancer-related mortality in the female population worldwide. Tumor cells exist within a highly oxidative microenvironment, which promotes the formation of substantial amounts of lipid…
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Bilateral Acute Angle-Closure Crisis Associated with Oral Tramadol Use After Robotic-Assisted Hysterectomy: A Case Report
Background and Clinical Significance: Tramadol-associated acute angle-closure crisis is rare and has been reported only once previously following subcutaneous administration. Acute angle closure may occur in anatomically predisposed individuals in the setting of perioperative physiological stress…
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Metabolomics in Infectious Diseases and Vaccine Response: Insights into Neglected Tropical and Non-Neglected Pathogens
Background/objectives: Metabolomics has emerged as a powerful systems-biology tool for deciphering dynamic metabolic alterations occurring during infectious diseases and following vaccination. While genomics and proteomics provide extensive molecular and regulatory information, metabolomics…
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Reliability of Joint Position Sense and Force Sense Measurements in Children with Developmental Coordination Disorder
Background: Quantitative assessment of proprioception in children with Developmental Coordination Disorder (DCD) is limited by methodological variability and the lack of developmentally appropriate protocols. Joint position sense (JPS) and force sense (FS) assessments are commonly used in adults…
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An Unusual Case of Listeria monocytogenes-Associated Rhombencephalitis Complicated by Brain Abscesses in Italy, 2024
Background/Objectives: Listeria monocytogenes (Lm) is an extremely rare cause of brain abscesses, accounting for 1–10% of neurolisteriosis cases reported in the literature, associated with high mortality (approximately 23%). Data on diagnosis, management, and treatment is scarce. We report a case…
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Delayed Neurologic Response to Dabrafenib and Trametinib in the Case of Mixed Histiocytosis (LCH/ECD): Case Report and Literature Review
Background and Clinical Significance: Histiocytosis encompasses Langerhans cell histiocytosis (LCH) and non-LCH, such as Erdheim–Chester disease (ECD). ECD or a mixed type of histiocytosis (LCH/ECD) may initially involve the central nervous system (CNS), resulting in a delayed diagnosis. More…
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Individual and Cumulative Health and Lifestyle Risk Factors for Depressive Symptoms in Older Adults: Evidence from NHANES
Background: Depression in older adults is a multifactorial condition influenced by health status, functional capacity, and lifestyle factors. This study aimed to investigate the individual and combined associations of these factors with late-life depression. Methods: Using data from the National…
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The Myokine FGF-21 Responds in a Time-Dependent Manner to Three Different Types of Acute Exercise
Background: The myokine response to various types of exercise may differ and influence the adaptations to various physiological systems in response to training. This study aimed to compare systemic myokines’ (apelin, interleukin-6 [IL-6], interleu-kin-15 [IL-15], fibroblast-growth factor-21…
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Visual Strategies of Avoidantly Attached Individuals: Attachment Avoidance and Gaze Behavior in Deceptive Interactions
Gaze behavior is a critical component of social interaction, reflecting emotional recognition and social regulation. While previous research has emphasized either situational influences (e.g., deception) or stable individual differences (e.g., attachment avoidance) on gaze patterns, studies…
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Preoperative Prognostic Score for Patients with Intrahepatic Cholangiocarcinoma Undergoing Curative-Intent Resection
Background: Preoperative inflammatory and nutrition-related markers—including the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), and controlling nutritional status (CONUT) score—have shown prognostic relevance in various malignancies…
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Rapid Inpatient Uptitration of Inhaled Treprostinil in PH-ILD Patients with Severe Phenotype
HIGHLIGHTS: What are the main findings? Rapid inpatient uptitration of inhaled treprostinil allowed all six severe PH-ILD patients to reach therapeutic dosing within one week. The protocol was well tolerated and associated with early hemodynamic improvement without dose interruptions or 90-day…
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A Cross-Sectional Analysis of Blood Spot per- and Polyfluoroalkyl Substances (PFAS) from Adolescents in Chitwan Valley, Nepal
Background/Objectives: Per- and polyfluoroalkyl substances (PFAS) are globally widespread contaminants linked to adverse health outcomes, including immune dysregulation. We aimed to characterize PFAS exposure among adolescents in Nepal. We conducted a cross-sectional study in Chitwan District…
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Robustness Evaluation of a Legacy N-Glycan Profiling Method for a Therapeutic Antibody Under ICH Q14 Lifecycle Principles
Background: This study assesses the robustness of a legacy N-glycan profiling method for the therapeutic antibody MAB1 with different Peptide-N-glycosidase F (PNGase F) enzyme sources, solid phase extraction (SPE) cartridges, and reagent stability, aligning with ICH Q14 lifecycle management…
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Trends of Tobacco and Alcohol Consumption Among People with Diabetes Mellitus in Spain: A Population-Based Study (2014–2020)
Background/Objectives: To examine trends in tobacco and alcohol consumption among individuals with and without diabetes mellitus (DM) in Spain from 2014 to 2020 and identify sociodemographic, lifestyle, and comorbidity-related predictors of consumption. Methods: Population-based cross-sectional…
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