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AI-Enabled Sacramento Public Health (SACPH) App: A Reproducible AI-Based Method for Population-to-Practice Reasoning in Foundational Sciences in Pharmacy Education
Foundational biomedical sciences are commonly taught without routine integration of local population health contexts, limiting students’ ability to connect mechanisms to community disease burden and practice responsibilities. In this method paper, we developed and piloted an AI-enabled “Sacramento…
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Exploring the Risk: Investigating the Association Between Elderly-Onset Sarcoidosis (EOS) and Malignancy
HIGHLIGHTS: What are the main findings? 1. Patients with EOS were more frequently female and exhibited a markedly higher prevalence of prior malignancy (OR ≈8.0) compared to younger-onset counterparts. First bullet. 2. Increasing age at sarcoidosis diagnosis was independent predictor of prior…
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Prognostic Value of Serial Lactate Measurement in Pediatric Cardiac Surgery Patients with Congenital Heart Disease in Southeast Mexico
Background/Objectives: Lactate, traditionally considered a byproduct of anaerobic metabolism, is increasingly recognized as a biomarker of tissue perfusion and systemic stress. While hyperlactatemia is frequent after pediatric cardiac surgery, evidence regarding its prognostic role remains…
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Case Report of Overlap of Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State in a 5-Year-Old with New-Onset Type 1 Diabetes Mellitus: Diagnostic and Management Considerations
Background and Clinical Significance: Overlap of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) in children is a rare but life-threatening metabolic emergency. The coexistence of hyperosmolality and ketoacidosis increases neurologic vulnerability and complicates fluid and…
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A Protocol for the Biomechanical Evaluation of the Types of Setting Motions in Volleyball Based on Kinematics and Muscle Synergies
Setting is a fundamental movement in volleyball. While there are several optimal interpreters of the role in professional play, there is a surprising lack of advanced measurement techniques for the evaluation of the movement from a biomechanical perspective. We proposed a comprehensive motion…
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Persistence of Symptoms and Long-Term Recovery in Hospitalized COVID-19 Patients: Results from a Five-Year Follow-Up Cohort
Background/Objectives: This study aimed to determine the prevalence of persistent symptoms and the radiological and laboratory evolution at 6 months and 5 years after discharge in patients hospitalized for SARS-CoV-2 pneumonia during the first wave of the pandemic in Spain and to estimate the…
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Prediction of Chronic Obstructive Pulmonary Disease Using Machine Learning, Clinical Summary Notes, and Vital Signs: A Single-Center Retrospective Cohort Study in the United States
HIGHLIGHTS: What are the main findings? Of the COPD exacerbation predictive models designed and assessed in our study, the clinical note-based support vector machine model achieved an AUC of 0.81 and accuracy of 84.0% in predicting COPD exacerbations. What are the implications of the main findings?…
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Effects of Whole-Body Electromyostimulation on Jumping, Sprinting and Agility Performance in Sportspeople and Athletes: Systematic Review and Meta-Analysis
Background: Whole-body electromyostimulation (WB-EMS) is a training technology that enables the stimulation of all the main muscle groups with dedicated intensity, attracting many sportspeople and athletes of various disciplines. The aim of this systematic review and meta-analysis was to determine…
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Beyond Addiction: Burden of Polypharmacy and Risk in Frail Patients with Substance Use Disorder
Substance use disorder (SUD) is a chronic and clinically complex condition, frequently complicated by significant organic and psychiatric comorbidities. Most patients are polymedicated and require opioid substitution programs (OSPs). This complexity is further exacerbated by drug–drug interactions…
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Structured Medication Review and Shared Decision-Making in Patients with Mild Intellectual Disabilities Who Use Psychotropic Medication
People with intellectual disabilities frequently use psychotropic and other medications, sometimes inappropriately. To promote shared decision-making, they require accessible information about their medication. This study combined data from two similar intervention studies, conducted in two…
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Multi-Scale Transcriptomics Redefining the Tumor Immune Microenvironment
The tumor immune microenvironment (TIME) is closely involved in tumor initiation, malignant progression, immune escape, and response to immunotherapy. With the continued development of high-throughput sequencing technologies, transcriptomic approaches have become essential for examining the…
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Discovery of New Markers for Haemogenic Endothelium and Haematopoietic Progenitors in the Mouse Yolk Sac
Erythro-myeloid progenitors (EMPs) originate from the haemogenic endothelium in the yolk sac via an endothelial-to-haematopoietic transition (EHT) to generate blood and immune cells that support embryo development. Yet, the transitory nature of EHT and the limited availability of molecular markers…
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Faster than Virus: The Physics of Pandemic Prediction
Background: Zoonotic spillover events with pandemic potential are increasingly associated with environmental change, ecosystem disruption, and intensified human–animal interactions. Although the specific origin and timing of future pandemics remain uncertain, there is a clear need to complement…
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Female Aging Affects Coilin Pattern in Mouse Cumulus Cells
Cumulus cells (CCs) are a distinct population of granulosa cells (GCs) that surround the developing and ovulated mammalian oocyte. The features of their structural organization and the expression pattern of key genes significantly affect oocyte viability. Changes in the functional activity of the…
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Bortezomib-Induced Sensorineural Hearing Loss May Be Reversible with Intratympanic Dexamethasone
Background: Bortezomib, a proteasome inhibitor used in multiple myeloma (MM), is associated with several adverse effects, most notably peripheral neuropathy. Ototoxicity, however, remains a rare and underrecognized complication. Case presentation: We report the case of a 74-year-old man with MM who…
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Conformity Assessment of Medical Devices: An Overview from a Notified Body
This perspective provides an in-depth analysis of the role and tasks of Notified Bodies (NBs) under the Medical Device Regulation (MDR) and In Vitro Diagnostic Regulation (IVDR). It explores the conformity assessment process and highlights typical issues encountered. It provides background on the…
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Early Rod Dysfunction Influences Cone Development in a Rhodopsin P23H Mouse Model of Retinitis Pigmentosa
Background/Objectives: The Rho(P23H/WT) mouse line is a commonly used model to study rhodopsin P23H-associated autosomal dominant retinitis pigmentosa. Previous studies in Rho(P23H/WT) mice have largely focused on retinal changes occurring at one month of age and later, and have indicated a…
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Ultrasound-Based Assessment of Shoulder Soft Tissue Alterations in Young Adults Performing Upper Limb Weight Training: A Cross-Sectional Study
Background: The subacromial space, measured as the acromiohumeral distance (AHD), is a key determinant of shoulder biomechanics and injury risk. Athletes performing repetitive upper-limb resistance training are particularly exposed to cumulative tendon stress. Musculoskeletal ultrasound (US)…
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In Patients with Dysimmune Motor and Sensorimotor Mononeuropathies, the Degree of Nerve Swelling Correlates with Clinical and Electrodiagnostic Findings
In non-vasculitic immune-mediated neuropathies, imaging studies demonstrate an enlargement not only of clinically involved but also of clinically intact nerves. The present study aimed to present a pattern of nerve swelling and its relation to nerve function. In a group of patients with dysimmune…
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