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Artikel Jurnal Teks lengkap
Therapeutic Potential of Exportin 1 and Aurora Kinase A Inhibition in Multiple Myeloma Cells
Background/Objectives: Aurora kinases (AURKs) are key regulators of mitosis, and their dysregulation contributes to plasma cell disorders, including multiple myeloma (MM) and plasma cell leukemia (PCL). Methods: The expression and prognostic relevance of AURK family members were examined, and the…
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Acute Effects of Different Muscle Contraction Types on Biomechanical and Viscoelastic Properties of the Biceps Brachii Measured with Myotonometry
Background: Acute alterations in biomechanical and viscoelastic muscle properties provide important insight into early fatigue mechanisms; however, their dependence on specific muscle contraction types remains insufficiently understood. Therefore, the aim of this study was to quantitatively compare…
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Recommendations Following Hospitalization for Acute Exacerbation of COPD—A Consensus Statement of the Polish Respiratory Society
HIGHLIGHTS: What are the main findings? A multidisciplinary team should be involved in developing discharge instructions after hospitalization for a chronic obstructive pulmonary disease (COPD) exacerbation to ensure clear, consistent, and comprehensive documentation. Discharge instructions should…
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Heterologous Production of Torularhodin, the Monocyclic Carotenoid with a Terminal Carboxyl Group, in Escherichia coli
Torularhodin is the monocyclic C40 carotenoid with the β-ring and a terminal carboxyl group at the acyclic part, with long conjugated double bonds, only synthesized in fungi called red (oleaginous) yeasts, e.g., the genera Rhodotorula and Sporobolomyces. This unique red pigment with strong…
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The Health and Physical Education Curriculum: Does It Address Muscular Fitness?
Background: The World Health Organization and the Australian physical activity guidelines, in line with contemporary research, recommend regular muscle-strengthening activities for optimal muscular fitness in children and adolescents. However, the extent to which muscle-strengthening or muscular…
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Beyond XX and XY, Understanding Sex Differences in Leukemia
The major subtypes of leukemia show sex differences. This review summarizes current knowledge and identifies gaps regarding sex differences across acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, and chronic lymphoblastic leukemia in epidemiology, mortality and…
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Iron-Containing Alcohol Dehydrogenase from Hyperthermophiles
Iron-containing alcohol dehydrogenases (Fe-ADHs) from hyperthermophiles represent a distinct class of oxidoreductases characterized by exceptional thermostability, catalytic versatility, and unique metal-dependent properties. Despite considerable sequence diversity, Fe-ADHs share conserved motifs…
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A Human Mass Balance and Metabolism Study of [(14)C]‐Ubrogepant in Healthy Male Adults
Ubrogepant is a calcitonin gene–related peptide receptor antagonist approved for the acute treatment of migraine with or without aura in adults. The mass balance and metabolism of ubrogepant was evaluated in six healthy male adults administered a single oral dose of [(14)C]‐ubrogepant 50 mg (∼200…
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Analyzing the “Opposite” Approach in Additions to Historic Buildings Using Visual Attention Tools: Dresden Military History Museum Case
From past to present, modern additions have continued to transform historic environments. While some argue that contemporary extensions disrupt the integrity of historic buildings, others suggest that the contrast between past and present creates a meaningful architectural dialog. This debate…
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Missing or Mis‐Telling the Story? Trade‐Offs for Restriction‐Site Associated Compared to Whole Genome Sequencing
Researchers must navigate several trade‐offs when deciding which population sequencing method to use. The decision between reduced representation approaches and whole genome sequencing (WGS) impacts marker density, sequencing depth and costs per sample, which will in turn affect the power to…
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Novel Biallelic PLEKHG5 Variant Associated With Intermediate Charcot‐Marie‐Tooth Disease: Case Report From South America
BACKGROUND AND AIMS: Biallelic pathogenic variants in PLEKHG5 are associated with two distinct recessive phenotypes, including distal hereditary motor neuropathy AR type 4 and intermediate Charcot‐Marie‐Tooth disease type C (CMT). No South American cases have been previously reported. METHODS: We…
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The Role of microRNAs as Potential Biomarkers in Diffuse Large B-Cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common and clinically aggressive subtype of non-Hodgkin lymphoma (NHL). While novel therapies such as rituximab and polatuzumab vedotin have led to improved outcomes, approximately 35% of patients eventually develop relapsed or refractory disease…
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Repeatability and Variability of a High-Fat High-Fructose Diet-Induced Metabolic Syndrome Model in Young Adult Male Wistar Rats
Metabolic syndrome is a disorder of energy metabolism characterized by persistently high prevalence and significant medical and economic burden on society. An effective animal model that closely replicates the key features of the syndrome in humans is essential for evaluating therapeutic strategies…
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Advancing Global Nursing Policy: AI‐Driven Health Literacy Innovations for Migrant Domestic Workers
AIM: This perspective proposes evidence‐informed strategies to advance health literacy equity for migrant domestic workers (MDWs) globally, integrating research findings and outlining nursing‐led policy directions for sustainable change. BACKGROUND: MDWs face language barriers, precarious…
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Inflammatory Biomarkers and Neurotrophic Factors in Preterm Newborns as Predictors of Motor Development: A Systematic Review
Background/Objectives: Preterm newborns (NBs) are at increased risk of motor developmental impairments. Evidence on inflammatory and neurotrophic biomarkers measured in the neonatal period as predictors of motor outcomes is scarce and heterogeneous. This systematic review synthesised data on…
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The state of genetic counseling supervision worldwide: Challenges, practices, and pathways for the future
Genetic counseling supervision (GCS), a structured process in which a professional supports a supervisee through reflection, case discussion, and skills development, plays a crucial role in ensuring the quality and effectiveness of genetic counseling services worldwide. Despite its advantages, the…
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Shared and Unique Patterns of Genomic Differentiation and Introgression Between Japanese Stickleback Species Across Three Sympatric Sites
Hybridization and introgression frequently occur even between distantly related species. A central question in speciation research is which genomic regions act as barriers to gene flow and how genome‐wide differentiation persists despite hybridization between species. Ecological divergence is well…
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First‐In‐Human Study to Assess the Pharmacokinetics and Safety of DS‐6016a After Single Subcutaneous Injection in Healthy Japanese Adults
Fibrodysplasia ossificans progressiva is a rare, progressive autosomal dominant genetic disease caused by an activin receptor‐like kinase 2 (ALK2) mutation with a need for effective prophylactic therapies. This single‐center, randomized, double‐blind, placebo‐controlled study evaluated the…
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Forensic Perspectives on Child Sexual Abuse Disclosure in Greece: A Retrospective Study
Purpose: Child sexual abuse (CSA) is a major public health and forensic concern, often involving delayed disclosure that limits evidence collection and affects judicial outcomes. This study analyzed disclosure patterns, victim–perpetrator characteristics, and forensic findings in CSA cases…
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