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Lipopeptides from Bacillus Probiotics Can Target Transmembrane Receptors NOX4, EGFR, PDGFR, and OCTN2 Involved in Oxidative Stress and Oncogenesis
Bacillus-derived lipopeptides are known to possess diverse biological activities, including antimicrobial and anticancer properties, though the mechanisms of such effects at the molecular level remain incompletely understood. We investigated whether non-ribosomal peptide metabolites from Bacillus…
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Impact of Perceived Dorsiflexion and Plantarflexion in the Squat and Countermovement Jumps
Muscular strength plays a crucial role in sports performance and is often evaluated using vertical jump tests such as the Squat Jump (SJ) and Countermovement Jump (CMJ). Measurements based on flight time (FT) assume that takeoff and landing postures are identical, yet differences in ankle position…
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Nationwide Study of Pediatric Drug-Resistant Epilepsy in Estonia: Lower Incidence and Insights into Etiology
Background/Objectives: Drug-resistant epilepsy (DRE) is a significant health problem leading to cognitive impairment and reduced quality of life. This study aimed to investigate the incidence and etiology of DRE in children in Estonia. Methods: A retrospective, population-based study of childhood…
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Strategy and Motivation, Rather Than Fatigue, Drive Age‐Related Differences in Sustained Attention Performance: Evidence for Decoupled Beta‐Band Oscillations
Reduced vigilance can be captured as attentional lapses in sustained attention tasks, but just how these lapses relate to task‐induced fatigue and motivation to maintain optimal performance across the age span is unclear. We induced fatigue in 18 young (mean age = 22.6 years) and 16 older…
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Developing an Evaluation Framework Based on Entrustable Professional Activities for Advanced Practice Nurses in China
AIM: To address conceptual ambiguity, unclear scope, and regulatory gaps hindering advanced practice nurse role implementation in China, this study developed an evaluation framework based on entrustable professional activities to facilitate the introduction, implementation, and development of the…
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The Role of Forgiveness Between Dysfunctional Thoughts and Anxiety in Older Adults’ Family Caregivers
Background/Objectives: Current studies have shown that caregiving anxiety is associated with an individual’s dysfunctional thoughts. The aim of this study was to assess the mediating effect of caregivers’ forgiveness (benevolence, lack of avoidance and lack of revenge) on the relationship between…
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Phenomenological research in the field of Infant Mental Health and Early Childhood (IECMH) ‐A mapping review
Infant Mental Health and Early Childhood (IECMH) is a field of study of infants and the developing relationship and the optimal development between infants and their caregivers. Phenomenological research within the well‐being of infants and caregivers has core importance in the comprehension of the…
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The fat‐heart entanglement and the role of ‘osteopontin mechanics’ in cardiometabolic senescence
BACKGROUND: Residual cardiovascular (CV) risk persists despite therapeutic advances. Obesity is heterogeneous, and visceral adipose tissue (VAT) dysfunction (‘adiposopathy’) complicates risk stratification. Osteopontin (OPN) is a pleiotropic mediator implicated in VAT inflammation…
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Heracleum sosnowskyi Manden. in the Context of Sustainable Development: An Aggressive Invasive Species with Potential for Utilisation in the Extraction of Furanocoumarins and Essential Oils
Heracleum sosnowskyi Manden., or H. sosnowskyi, of the Apiaceae was first cultivated in the USSR in 1947 as a potential fodder plant. Due to the development of cold-resistant cultivars and the characteristics of H. sosnowskyi, it quickly became feral. As a result, H. sosnowskyi began to spread as…
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Urinary Metabolomics as a Window into Occupational Exposure: The Case of Foundry Workers
Foundries represent complex exposure scenarios where metals, particulate matter, and combustion by-products coexist, posing potential cumulative biological effects. Urinary metabolic profiles from 64 foundry workers and 78 residents living in surrounding areas were investigated using multivariate…
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Decoding Cerebrospinal Fluid: Integrative Metabolomics Across Multiple Platforms
Cerebrospinal fluid (CSF) is a key biological matrix that reflects the physiological and pathological states of the central nervous system (CNS). It supports brain function by regulating ionic balance, facilitating molecular transport, and clearing metabolic waste. In this article, we present a…
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Bispecific Antibodies: Strategies Available to Optimize Their Safe Delivery in Patients with Multiple Myeloma
Bispecific antibodies (BsAbs) have emerged as an important new class drugs for the treatment of multiple myeloma (MM) over the last few years. Currently, BsAbs are only licensed for use as monotherapy in patients with relapsed/refractory MM who have had at least three prior lines of treatment and…
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Experimental and In Silico Approaches to Study Carboxylesterase Substrate Specificity
Human carboxylesterases (CES) are enzymes that play a central role in the metabolism and biotransformation of diverse endogenous substances and xenobiotics. The two most relevant isoforms, CES1 and CES2, are crucial in clinical pharmacotherapy as they catalyze the hydrolysis of numerous approved…
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Methodologies of Care: A Multimodal, Participatory Research Approach with Vulnerable Families Among South African Communities
Multimodal methods provide valuable opportunities within Participatory Action Research (PAR), to foster meaningful participation, and amplify marginalized voices. However, conventional research approaches have not always adequately captured the complex realities of the lived experiences of…
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Rehabilitation interventions for oropharyngeal dysphagia in people with Parkinson's disease
RATIONALE: Oropharyngeal dysphagia is a common and disabling symptom in people with Parkinson’s disease, affecting the safety and efficiency of swallowing and increasing the risk of malnutrition and aspiration pneumonia. Despite its clinical relevance, the effectiveness of rehabilitation…
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Simulation of the Impact of Pesticides on Pollinators Under Different Conditions Using Correlation Weighting of Quasi-SMILES Components Together with the Index of Ideality of Correlation (IIC)
Background: Pesticide toxicity to insects is an important adverse effect with a potentially large ecological impact when considering the effect on beneficial insects, as pollinators. The assessment of this endpoint is necessary to avoid applying ecologically dangerous pesticides. Aim of the study…
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Evolution of Carpal Tunnel Syndrome Treatment: A Narrative Review
Carpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment disorder, with a lifetime prevalence estimated at approximately 10%. This narrative review explores the historical evolution, current management strategies, and emerging trends in CTS diagnosis and treatment. Early…
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Probiotic and Prebiotic Supplementation for Gastrointestinal Discomfort in Chronic Spinal Cord Injury (PRO-GIDSCI): A Randomized Controlled Crossover Trial Protocol
Background: Gastrointestinal discomfort affects up to 70% of individuals with spinal cord injury (SCI), largely due to gut dysbiosis caused by altered transit time and reduced gastrointestinal motility from autonomic disruption. Emerging evidence links prebiotics and probiotics to improved…
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Moderate Exercise Stimulates PACAP-Mediated Neurogenesis in Rat Dentate Gyrus and Cerebellar Cortex
Background: Moderate physical activity (PA) exerts powerful systemic and neuroprotective effects, reducing chronic disease risk and enhancing cognitive and psychological well-being. PA promotes brain plasticity by upregulating neurotrophic factors and stimulating neurogenesis. Given the established…
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Medicinal Honeys from Oceania: An Updated Review on Their Bioactive Constituents and Health Applications
Medicinal honeys from Oceania have gained considerable attention due to their peculiar bioactive constituents and potential health applications. Apart from small molecules such as methylglyoxal and hydrogen peroxide, these honeys are rich in phenolic compounds, volatile terpenes, and other…
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