11.943.971 hasil
Menampilkan 21–40 · 3,42 detik · RSS
-
Artikel Jurnal Teks lengkap
A prospective, randomized, controlled trial of TB treatment shortening guided by PET/CT imaging
Six months of drug treatment is standard of care for drug-sensitive pulmonary tuberculosis (TB). Understanding the factors determining the length of treatment required for durable cure would allow individualization of treatment durations. We conducted a prospective, randomized, controlled…
-
Artikel Jurnal Teks lengkap
The modulation of human motoneuron discharge patterns with contraction force in resistance- and endurance-trained individuals
Motoneurons adapt to both resistance and endurance training in reduced animal preparations, with adaptations seemingly more apparent in higher threshold neurons, but similar evidence in humans is lacking. We compared identified motor unit (MU) discharge patterns from decomposed electromyography…
-
Artikel Jurnal Teks lengkap
Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli
Astrocytes are increasingly recognized as active participants in sensory processing, but whether they show selective responses to stimulus features, analogous to neuronal receptive fields, is not yet established. To address this, we used two-photon calcium imaging in the auditory cortex of…
-
Artikel Jurnal Teks lengkap
The status and politics of bicycling in the cities of low- and middle-income countries
Bicycling is promoted in low- and middle-income countries to reduce emissions and improve public health. However, transportation policies often replicate built infrastructure logics from high-income countries, with limited attention to local bicyclists’ experiences and contextual realities. Here…
-
Artikel Jurnal Teks lengkap
Fisher Perceptions and Management Challenges in KwaZulu-Natal’s Inland Water Bodies
Inland fisheries in South Africa are crucial for the livelihoods of local communities, but they face pressures that threaten the sustainability of small-scale and recreational fishers livelihoods, the latter making the dominant economic contribution. However, distinctions between small-scale and…
-
Artikel Jurnal Teks lengkap
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural complexity impede self-replication and preclude their spontaneous emergence. Here we describe QT45…
-
Artikel Jurnal Teks lengkap
Relief with a catch: hemodilution in chronic mountain sickness sparks an erythropoietin surge
-
Artikel Jurnal Teks lengkap
Greening mitigates heat-related mortality in Paris
Cities are vulnerable to heat-related health impacts due to the compounding effects of urban heat island (UHI) and rising temperatures because of climate change. Here we characterise the contextual factors exacerbating and attenuating the risk of mortality associated with high temperature in the…
-
Artikel Jurnal Teks lengkap
Optimising the choice of normalisation method for use in machine-learning classification of human blood plasma ambient ionisation mass spectra
Construction of large mass spectrometric data sets usually involves some combination of normalisation, scaling, and transformation of individual mass spectra in order to correct for technical (and sometimes biological) variation. Many different approaches to data normalisation have been reported…
-
Artikel Jurnal Teks lengkap
Waiting objects: letters as containers of time and care
In this epistolary paper, we draw on the work of an interdisciplinary, psychosocial study of the relationship between time and care, Waiting Times, to explore the significance of a book of letters as a waiting object. Words in Pain, a collection of letters by Olga Jacoby (1874–1913) to her doctor…
-
Artikel Jurnal Teks lengkap
Positive bias in brain and behaviour as a mechanism of transcranial magnetic stimulation depression treatment
Transcranial magnetic stimulation (TMS) is a novel approved therapy for treatment-resistant depression. Little is known about its neurocognitive mechanisms of action. The existing literature has focused on resting-state neuroimaging. It therefore remains unknown what information processing changes…
-
Artikel Jurnal Teks lengkap
Influence of Grading and Layer Thickness on Stress Distribution in Dental Ceramics: A Finite Element Analysis
INTRODUCTION: Functionally graded designs have been explored in dental ceramics to reduce stress concentrations in layered dental ceramics and enhance their mechanical properties. MATERIALS AND METHODS: Varying wt.% of 3 mol% yttria-stabilized zirconia (20, 35, 50 wt.% YSZ) in fluormica glass…
-
Artikel Jurnal Teks lengkap
Self-report of 24-h urine completeness compared with para-aminobenzoic acid (PABA) recovery does not bias estimates of dietary salt intake in the UK
The measurement of sodium excretion in 24-h urine samples is the recommended method to assess dietary salt intake to monitor salt-related public health policies. Ensuring complete collection of 24-h urine samples is important for the accurate assessment of salt intake. We compare the use of the…
-
Artikel Jurnal Teks lengkap
Task-dependent changes in the cortical control of postural dual tasks: effects of secondary cognitive and motor tasks
This study investigated whether the motor cortical control underlying dual task performance depends on the type and difficulty of the dual task. Forty-four adults stood on a balance platform with or without performing a secondary motor (i.e., maintain a ball in the middle of a tray) or cognitive…
-
Artikel Jurnal Teks lengkap
Structural Tuning of Vidofludimus for High-Efficacy NR4A Agonism
The nerve growth factor IB-like receptors (NR4A) are (neuro)protective transcription factors as part of the immediate early response and hold potential in various pathologies including neurodegeneration. Despite recent progress in NR4A ligand development, high-quality chemical tools to probe…
-
Artikel Jurnal Teks lengkap
Systematic optimization of fragment TLX ligands towards agonism and inverse agonism
The transcription factor tailless homologue (TLX, NR2E1) maintains persistence of neural stem cells (NSC) in a proliferating, undifferentiated state thereby controlling NSC homeostasis and enabling neurogenesis. TLX is responsive to small molecule ligands offering potential access to new…
-
Artikel Jurnal Teks lengkap
The pathway to diagnosis and follow-up care for atrial fibrillation in Sri Lanka: a descriptive longitudinal study
BACKGROUND: Early diagnosis and continuity of care is vital for atrial fibrillation (AF), to reduce stroke ; There is a lack of understanding of when and how AF is being diagnosed and managed the care pathway) in in low- and middle-income countries (LMICs). We aimed to identify the AF care pathway…
-
Artikel Jurnal Teks lengkap
Reliability of ankle dorsiflexor muscle strength, rate of force development, and tibialis anterior electromyography after stroke
BACKGROUND: Measures of hemiparetic ankle dorsiflexor muscle strength and rate of force development (RFD) are often used to determine the efficacy of rehabilitation interventions after stroke. However, evidence supporting the reliability of these measures is limited. This brief report provides a…
-
Artikel Jurnal Teks lengkap
A study to determine a capillary alternative to the gold standard oral glucose tolerance test - Protocol
Type 1 diabetes (T1D) is a chronic condition caused by the immune destruction of the pancreatic beta cells. T1D has recognised asymptomatic pre-clinical stages, providing an opportunity for early diagnosis, education and treatment which may delay the onset of symptoms. The oral glucose tolerance…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.