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Artikel Jurnal Teks lengkap
Severe anaphylaxis following off-label rectal use of injectable diazepam in a febrile seizure: a case report and clinical implications
BACKGROUND: Off-label rectal administration of intravenous diazepam is commonly practiced for acute seizure management in children when FDA-approved rectal gels (e.g., Diastat(®) AcuDial) are inaccessible—particularly in low-resource settings like Vietnam. However, such injectable formulations…
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Artikel Jurnal Teks lengkap
Multi-site harmonization for magnetoencephalography spectral power data
A known issue with multi-site studies is the presence of site-specific effects that may confound effects of interest. These effects may be additive, multiplicative, or both. Numerous strategies have been developed and tested on microarray data from multiple batches, structural magnetic resonance…
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Artikel Jurnal Teks lengkap
Level up the brain! Novel PCA method reveals key neuroplastic refinements in action video gamers
Action video games (AVGs) provide an ecologically rich context for examining how sustained cognitive demands relate to behaviorally induced neuroplasticity. In this cross-sectional study, we show that the connectivity differences observed in long-term AVG players, referred to here as gamers…
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Artikel Jurnal Teks lengkap
An Integrated Method for Profiling Lipid–Protein Interactions Using Multifunctional Lipid Probes
Cellular lipids shape health and disease through specific protein interactions, yet lipid-protein networks remain poorly defined. Despite rapid advances in functional lipid probes, the field still lacks a practical, dedicated protocol for conducting lipid-protein interaction studies. We describe…
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Artikel Jurnal Teks lengkap
Addressing Commercial Health determinants: Indigenous Empowerment and Voices for Equity (ACHIEVE)—protocol for a multiphase study
ABSTRACT: INTRODUCTION: The commercial determinants of health (CDoH) are a rapidly growing field of research and global health priority. Despite being disproportionately affected, Indigenous Peoples’ voices and perspectives are conspicuously absent from CDoH research and policy. This article…
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Artikel Jurnal Teks lengkap
Palliative care utilisation in migrant populations: protocol for a scoping review
INTRODUCTION: Migrants are vulnerable to structural barriers that compromise their health status and simultaneously decrease their access to healthcare, including palliative care. Literature on palliative care access in migrant populations is limited by a focus on migration to high-income…
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Artikel Jurnal Teks lengkap
Telitacicept versus belimumab for the treatment of systemic lupus erythematosus: a network meta-analysis and cost-effectiveness analysis
OBJECTIVES: Both telitacicept and belimumab are approved for treating active systemic lupus erythematosus (SLE) in China. However, the economic value of these two drugs is unclear. Therefore, this study aims to evaluate the cost-effectiveness of telitacicept versus belimumab in SLE from the…
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Understanding preferences for behaviour change support as part of the NHS Health Check: a qualitative study with adults from underserved minoritised ethnic communities
INTRODUCTION: NHS Health Checks (NHSHCs) provide individuals with cardiovascular disease (CVD) risk scores alongside advice and signposting to behaviour change support. A particular problem is that the support people receive is often poorly delivered, absent or not tailored to the needs of people…
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Artikel Jurnal Teks lengkap
Thoracic metastasis of a pediatric posterior fossa group A ependymoma: a rare case and literature review
Ependymomas are rare central nervous system tumors, with posterior fossa group A (PFA) ependymomas representing an aggressive pediatric subtype. While cerebrospinal fluid dissemination is well recognized, hematogenous spread and extracranial metastasis remain exceedingly rare and poorly understood…
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Hydroxychloroquine as an adjunct therapy in the management of type 2 diabetes in pregnancy: study protocol for a randomised controlled trial
INTRODUCTION: The increasing incidence of type 2 diabetes mellitus (T2DM) among women of reproductive age poses significant health risks for both mothers and their fetuses. Optimising blood glucose levels during pregnancy is particularly challenging, even with a combination of oral antidiabetic…
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Artikel Jurnal Teks lengkap
Visual content and thematic analyses of images shared on social media before and after episodes of self-harm in a UK clinical youth sample
OBJECTIVES: Little is known about how young people use social media during periods of self-harm. This study aimed to explore how they express themselves online through images posted on social media before and after self-harm and how this expression may change across these periods, employing visual…
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Artikel Jurnal Teks lengkap
Use of claims data to identify adverse events after colonoscopy in a randomised colorectal cancer screening trial in Norway: a cross-sectional study
OBJECTIVES: Accurate identification of adverse events after colonoscopy is essential for quality assurance in colorectal cancer (CRC) screening. Review of medical records is labour intensive as adverse events are infrequent. The object of this study was to investigate the accuracy of claims data in…
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Western pediatric cervical spine study: an observational prospective Western Pediatric Surgery Research Consortium and Western Trauma Association multicenter study protocol
BACKGROUND: In pediatric patients presenting after blunt trauma, the incidence of clinically significant cervical spine injury (CSI) is approximately 1%. Although multidetector CT (MDCT) is widely accepted for cervical spine clearance in adults, its utility in children remains uncertain. The…
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Artikel Jurnal Teks lengkap
Identifying priority diseases and injuries to promote equality as measured by health-adjusted life expectancy: a population-based study
STUDY OBJECTIVE: Promoting healthy lifespan equity is a pivotal challenge in the global wave of population ageing, aiming to enable the majority of people in today’s long-lived societies to reach a similar age in good health. This study aims to develop a systematic analytical framework to identify…
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Prevalence, time trends and associated factors of adult overweight and obesity in 36 countries in the WHO African region from 2003 to 2022: a study of 54 WHO STEPS surveys representing 156 million adults
BACKGROUND: We investigated the prevalence, temporal trends and associated factors of overweight and obesity among adults in the WHO African region. METHODS: We analysed individual-level data from 54 nationally/sub-nationally representative STEPS surveys conducted between 2003 and 2022 among adults…
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Gender dynamics in authorship of scientific publications in obstetrics and gynaecology: a 10-year bibliometric analysis of six high-impact journals
ABSTRACT: OBJECTIVE: Although obstetrics and gynaecology (O&G) is a predominantly female specialty, previous studies have suggested that women remain under-represented in academic authorship. This study evaluates trends in female and male first and last authorship in six leading O&G journals (Human…
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Artikel Jurnal Teks lengkap
Effectiveness of domestic food hygiene interventions on the microbiological quality of child food and childhood diarrhoea: a systematic review and meta-analysis
BACKGROUND: Foodborne diseases are an important cause of global morbidity and mortality, particularly among children who often experience diarrhoeal illnesses linked to foodborne enteric infections. Evidence on the effectiveness of interventions to reduce diarrhoea remains limited. This review…
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Artikel Jurnal Teks lengkap
Deep brain stimulation for Parkinson’s disease in Thailand: cost, utility and policy implications for universal health coverage
BACKGROUND: Parkinson’s disease (PD) is a chronic, progressive, disabling neurodegenerative disorder. Deep brain stimulation (DBS) surgery is a highly effective and beneficial therapy for advanced PD, but its substantial cost limits accessibility. This study aimed to evaluate the cost–utility and…
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Artikel Jurnal Teks lengkap
Treatment of bulbar urethral strictures with Optilume drug-coated balloons in a previously untreated population (FIRST-CARE): protocol for a single-blind multicentre randomised controlled trial
INTRODUCTION: Minimally invasive endoscopic procedures constitute the cornerstone of first-line treatment for bulbar urethral strictures, although their long-term effectiveness is limited by high recurrence rates. The Optilume drug-coated balloon (DCB) is a novel intervention combining mechanical…
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Artikel Jurnal Teks lengkap
Non-superagonist CD28-based dual-signal T cell engager targeting KK-LC-1 enhances antitumor efficacy
BACKGROUND: Bispecific T cell engagers have demonstrated promising clinical progress in both hematologic malignancies and solid tumors; however, their therapeutic efficacy is still limited by multiple challenges including T cell anergy resulting from single-signal activation exclusively through CD3…
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