11.943.971 hasil
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Artikel Jurnal Teks lengkap
Selecting measures of visual function to classify diabetic retinopathy status: a cross-sectional study
AIM: To identify combinations of up to three visual function tests with the best performance for classifying diabetic retinopathy (DR) severity stage. To describe in detail the measurements from a comprehensive set of visual function tests. METHODS: 1901 eyes (1032 participants) underwent nine…
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Exploring cardiac autonomic dysfunction in synucleinopathies with parkinsonism through awake–sleep stages: a possible connection to cardiovascular death
INTRODUCTION: Alpha-synucleinopathies (ASs), including Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies, are characterised by autonomic dysfunction that may predispose to cardiovascular events and sudden death. Heart rate variability (HRV) is a non-invasive marker of…
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Women’s experiences of wound dehiscence of a second-degree perineal tear and choice of treatment in Denmark: a qualitative interview study
ABSTRACT: OBJECTIVE: This study aimed to describe women’s experiences of perineal wound dehiscence of a second-degree perineal tear and choice of resuturing or conservative treatment in the first two months after birth. DESIGN: A qualitative descriptive study using individual semistructured…
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Exploring syndemic vulnerability among adolescents living in urban cities in the Netherlands: a latent class analysis
BACKGROUND: The increase of adolescent multimorbidity in welfare states is a major concern for current and future population health. However, current health interventions remain insufficient. Syndemic research among adolescents in high-income countries could improve understanding of mechanisms…
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Data-driven queueing modelling: a simulation case study of emergency department crowding
OBJECTIVES: Emergency department crowding refers to a complex state of congestion associated with a set of performance indicators such as occupation levels, waiting times and specific scores. Among current methods to model it, an objective gap exists between forecasting machine learning methods…
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Artikel Jurnal Teks lengkap
Ocular diseases and their association with mortality in intensive care unit patients: a retrospective cohort study from the MIMIC-IV database
INTRODUCTION: Ocular diseases, though common in intensive care unit (ICU) patients, are often overlooked due to prioritisation of organ failure management. Their comorbidities, clinical features and prognostic effects require large-scale investigation. MEASUREMENTS AND MAIN RESULTS: This study used…
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Artikel Jurnal Teks lengkap
Challenges and solutions to participation in mental health clinical trials: Count Me In 2.0
Mental health clinical trials in the UK face significant recruitment barriers, with mental health studies comprising just 3.3% of approved interventional medicinal product trials. Challenges include the limited numbers of trials and clinician gatekeeping—where clinicians decide whether or not to…
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Consolidation of health data to improve health data governance using the Multi-Source Data Analytics and Triangulation platform
OBJECTIVE: This paper explores the implementation of the Multi-Source Data Analytics and Triangulation (MSDAT) platform as a solution to Nigeria’s health data challenges. By consolidating data from various sources into a centralised platform, MSDAT aims to improve data accessibility…
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Patient-reported experience measure (PREM) for patients with interstitial lung disease (ILD): modification of a pre-existing measure
OBJECTIVE: Patient-reported experience measures (PREMs) are a key component of healthcare accountability frameworks, health policy, integrated care board commissioning and integrated care partnerships generating data which are crucial markers of patient care quality. The Rheumatoid Arthritis…
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Interventions aimed at improving psychosocial safety climate in the workplace: a scoping review protocol
ABSTRACT: INTRODUCTION: Psychosocial safety climate (PSC) is increasingly recognised as an important organisational resource for promoting mental health at work and preventing psychosocial risks, which are aspects of work design, organisation and management that could threaten employees'…
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How epistemic trust, mistrust and credulity relate to mental health, personality pathology, treatment engagement and relationship in psychotherapeutic and psychiatric settings
BACKGROUND: Epistemic trust describes the capacity to appropriately identify others as reliable and relevant sources of information, an ability closely linked to attachment and social learning. Epistemic disruption can manifest as heightened suspicion (mistrust) or excessive reliance (credulity)…
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Characteristics of mental health awareness programmes for workplace well-being in low-income and middle-income countries: a scoping review
OBJECTIVES: Workplace-based mental health awareness programmes are increasingly promoted to support employee well-being; however, evidence from low-income and middle-income countries (LMICs) remains fragmented. This scoping review aimed to map and synthesise the characteristics of workplace-based…
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Medico-legal considerations in post-mortem imaging data: governance, ethics, and evidential use
Post-mortem imaging, in particular CT (PMCT), is increasingly used for death investigation in England and Wales, yet unlike “live” clinical imaging, this data falls outside traditional health-record legislation, creating uncertainty around data ownership, access rights, and disclosure obligations…
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Artikel Jurnal Teks lengkap
Preeclampsia 2.0: limitations and challenges of the two-stage hypothesis, and beyond
The pregnancy-specific syndrome preeclampsia remains the syndrome of hypotheses. Still, there is not a single hypothesis explaining the etiology of the full spectrum of preeclampsia. This has direct consequences for the clinical management of the syndrome. So far, no single early biomarker has been…
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Endogenous Processes Underlying Clock‐Like Mutational Signatures
Wellcome Trust scientists have shown that “mutational signatures” in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identified more than 50 single‐base substitution (SBS)…
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Pacific Australia Labour Mobility Workers in Australia: Lived Experiences of Health and Navigating Health Systems
OBJECTIVES: Pacific Australia Labour Mobility (PALM) scheme workers (hereafter referred to as PALM participants) are integral to Australia's economic landscape, contributing predominantly to agriculture and meatworks sectors. Many PALM participants come from regions with high burdens of blood‐borne…
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Reducing Health Inequities in Australia: The Role of Place‐Based Action and Spatial Data Infrastructure
Australia holds one of the world's highest life expectancies, yet stark geographic inequities persist. In Queensland, the gap in median age of death between communities only 85 km apart reaches 26 years for men and 22 years for women. While national policies increasingly endorse…
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Inspiratory muscle training in the healthy adult: The relationship between load, perception, and oxygen consumption
BACKGROUND: Inspiratory muscle training (IMT) is used in a broad range of populations to improve the strength and endurance of the respiratory muscles, to improve both athletic performance and clinical outcomes. However, the optimal approach to IMT remains uncertain, and IMT is frequently declined…
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Perceptions of the Role of Diet Among People With Constipation: Dietary Contributors and Relievers to Symptoms and Research Priorities
BACKGROUND AND AIMS: Diet is a potential management option for constipation; however, people's perceptions regarding its role and their dietary behaviours are unclear. The aim of this study was to explore the perceptions of the role of diet in constipation, including dietary contributors and…
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HLA‐Knockout: Enabling Allele‐Specific Knockout of HLA Class I Genes for Immunogenic Engineering
The interaction between T‐cell receptors (TCRs) and antigenic peptides presented by HLA molecules is fundamental to adaptive immunity. However, the extreme polymorphism of HLA genes poses major challenges for transplantation, antigen discovery, immunotherapy and studies of allele‐specific function…
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