11.943.971 hasil
Menampilkan 521–540 · 5,49 detik · RSS
-
Artikel Jurnal Teks lengkap
Molecular Landscape of TP53/RB1 Co‐Altered Tumors Uncovers Emerging Therapeutic Vulnerabilities
BACKGROUND: Although TP53 and RB1 co‐alterations play critical roles in promoting malignant development and progression, specific inhibitors targeting this co‐alteration are lacking. We performed a pan‐cancer analysis to characterize the biology of TP53/RB1 co‐alterations and identify therapeutic…
-
Artikel Jurnal Teks lengkap
Genomic Architecture of Inbreeding Depression Associated With Hatching Failure in an Endangered Parrot
Conservation management of endangered species increasingly relies on genomic approaches to understand how long‐term small population sizes affect the fitness of extant individuals. However, despite the growing investment in genomic resources by conservation programmes, the impact that sequencing…
-
Artikel Jurnal Teks lengkap
Extending the Use of Mendelian Randomisation With Non‐Inherited Variants to Assess Socially Transmitted Parental Exposures Under Assortative Mating
A longstanding aim of developmental psychology and epidemiology is to understand the causal effects of parental phenotypes on offspring outcomes. Traditional approaches often fail to account for confounding and reverse causation. We evaluate the use of Mendelian randomisation with non‐inherited…
-
Artikel Jurnal Teks lengkap
Cross‐Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits
Accurate prediction of disease risk and other complex traits across different populations is essential for clinical and research purposes. However, genetic differences among ancestries, such as allelic frequencies and genetic architecture, can affect the performance of polygenic risk score (PGS)…
-
Artikel Jurnal Teks lengkap
Structure and Spectroscopy of Triruthenium Dodecacarbonyl, Ru(3)(CO)(12)
We have reinvestigated the structure and vibrational spectroscopy of triruthenium dodecacarbonyl, Ru(3)(CO)(12), in the solid state by neutron powder diffraction, inelastic neutron scattering (INS), infrared and Raman spectroscopies. We find that the known room temperature P2(1)/n structure is…
-
Artikel Jurnal Teks lengkap
Inverse-Sandwich Rare Earth Metal Complexes Comprising a Planar Toluene Dianion
We report the first inverse-sandwich complexes containing rare earth (RE(III)) metal ions that captured a toluene dianion between them. Toluene-bridged complexes [{(Me(3)Si)(2)NC(N(i)Pr)(2)}(2)RE](2)(μ-η(6):η(6)-C(6)H(5)Me) (RE = Y (1), Dy (2), and Er (3)) were synthesized via chemical reductions…
-
Artikel Jurnal Teks lengkap
Optimizing Intracellular Transport of Antimicrobial Metallohelices Delivers Selective Nanomolar Potency in E. coli
To investigate large discrepancies in antimicrobial potency between cationic amphipathic metallohelix architectures, 22 new optically pure candidates were synthesized via self-assembly. A total of 34 compounds were tested against S. aureus, E. coli, and, for the most active, against a panel of…
-
Artikel Jurnal Teks lengkap
Cationic and Neutral Heterometallic Ir-Group 12 Element Polyhydride Compounds: Synthesis, Structure and Reactivity
The preparation and reactivity of some Ir–Zn and Ir–Cd heterometallic hydride complexes are described. Treatment of [Ir(IPr)(2)H(2)][BAr(F) (4)] (1; IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene; Ar(F) = 3,5-C(6)H(3)(CF(3))(2)) with M′R(2) (M′ = Zn; R = Ph, Me, Et; M′ = Cd, R = Me) and…
-
Artikel Jurnal Teks lengkap
Modeling Mo(VI)O Biologically Related Interactions with Oximes and Hydroxylamines: Implications for Uranium Seawater Extraction
Molybdenum enzymes play a crucial role in the nitrogen cycle processes. However, the mechanism of Mo(VI) reduction by hydroxylamine/oximes and its implications for oxime-based sorbents remain unclear. For decades, it has been widely accepted that the reaction of NH(2)OH with Mo(VI) consistently…
-
Artikel Jurnal Teks lengkap
Phenylpyridine-Based Borenium Salts as Lewis Acid Catalysts for Homocoupling of Diaryldiazomethanes
Cationic borenium salts have emerged as powerful Lewis acids, but their potential in carbon–carbon bond formation remains largely unexplored. Here, we report the synthesis of a family of sterically and electronically differentiated arylpyridine-based borenium species prepared by controlled hydride…
-
Artikel Jurnal Teks lengkap
Compositional Tuning of Magnetic Properties in a Series of Transition Metal Site-Deficient UCo( x )Bi(2) and UNi( x )Bi(2) Phases
Varying the electronic structure of topological materials through aliovalent substitution is a primary approach to tuning their physical properties. Unlike substitution, metal site deficiency intrinsic to some structure types, including HfCuSi(2)-type, has rarely been employed for controlling the…
-
Artikel Jurnal Teks lengkap
Peroxo-Thorium(IV)-Containing Heteropolytungstates and Their Oxo-Analogues: Synthesis, Structure and Solution Studies
We report the synthesis of peroxo-thorium(IV)-containing silico- and germanotungstates, [Th(3)(μ(3)-O(2))(OH)(2)(H(2)O)(3)(A-α-XW(9)O(34))(2)](12−) (X = Si, Th ( 3 ) O ( 2 ) Si; Ge, Th ( 3 ) O ( 2 ) Ge), prepared in aqueous solution via a straightforward two-step procedure: (1) reaction of…
-
Artikel Jurnal Teks lengkap
Feasibility of detecting cognitive impairment and psychological well-being among older adults using facial, acoustic, linguistic, and cardiovascular patterns derived from remote conversations
The aging society urgently requires scalable methods to monitor cognitive decline and identify social and psychological factors indicative of dementia risk in older adults. Our machine learning models captured facial, acoustic, linguistic, and cardiovascular features from 39 older adults with…
-
Artikel Jurnal Teks lengkap
Vessels in Middle-Earth: meeting report from the 2025 Australasian Summit on Vascular Biology and Microcirculation
The 2025 Australasian Summit on Vascular Biology and Microcirculation, jointly hosted by the Australian Vascular Biology Society (AVBS) and the Australian and New Zealand Microcirculation Society (ANZMS), convened in Queenstown, New Zealand, bringing together researchers, clinicians, and trainees…
-
Artikel Jurnal Teks lengkap
Development of a risk model for low oocyte retrieval in first-cycle IVF patients with diminished ovarian reserve: a retrospective single-center study
ABSTRACT: Low oocyte retrieval (LOR), defined as oocytes retrieved from
-
Artikel Jurnal Teks lengkap
lncRNAs: a new generation of targets and biomarkers in thyroid cancer
Long non-coding RNAs (lncRNAs) are untranslated RNA molecules that regulate gene expression through diverse mechanisms, acting as scaffolds, guides, decoys, or signals. In thyroid cancer, the most prevalent endocrine malignancy, lncRNAs are increasingly recognized as key contributors to tumor…
-
Artikel Jurnal Teks lengkap
Fallen-leaf-sensitized biosolar oxygenation of hydrocarbons
Lignocellulosic wastes are naturally abundant carbon resources but have been underutilized due to their complex structure and recalcitrant nature. They require energy- and water-intensive processes, such as thermal, chemical, and/or mechanical pretreatments, for their valorization. Here, we report…
-
Artikel Jurnal Teks lengkap
Correction to “Graphene-Based Polymeric Microneedles for Biomedical Applications: A Comprehensive Review”
-
Artikel Jurnal Teks lengkap
Synthesis of Pellet-Based Pd/C Egg-Shell Catalysts for Reversible Hydrogen Storage in Formate/Bicarbonate
We report the scalable synthesis of egg-shell Pd/C pellet catalysts for the reversible formate/bicarbonate hydrogen-storage cycle. This system is inherently safe, nontoxic and allows for the easy control of hydrogen storage and release through pressure or temperature. A simple synthesis protocol…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.