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Artikel Jurnal Teks lengkap
An NF-κB and Slug Regulatory Loop Active in Early Vertebrate Mesoderm
Background: In both Drosophila and the mouse, the zinc finger transcription factor Snail is required for mesoderm formation; its vertebrate paralog Slug (Snai2) appears to be required for neural crest formation in the chick and the clawed frog Xenopus laevis. Both Slug and Snail act to induce…
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Increased Nucleotide Diversity with Transient Y Linkage in Drosophila americana
Recombination shapes nucleotide variation within genomes. Patterns are thought to arise from the local recombination landscape, influencing the degree to which neutral variation experiences hitchhiking with selected variation. This study examines DNA polymorphism along Chromosome 4 (element B) of…
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PLoS Computational Biology Issue Image | Vol. 2(12) December 2006
Region of the Protein Homology Network : Closeup view of a region of the Protein Homology Network (PHN) that allows displaying either the homology relationships within a family or the genetic distance between the members. Protein families show a high density of connections. Different colors…
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Artikel Jurnal Teks lengkap
PLoS Genetics Issue Image | Vol. 2(12) December 2006
Jigsaw representation of eukaryote evolution: The jigsaw image of representatives of various lines of eukaryote evolution reflects the current lack of consensus as to how the major branches of eukaryotes fit together. The illustrations from upper left to bottom right are as follows: a single scale…
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Artikel Jurnal Teks lengkap
PLoS Pathogens Issue Image | Vol. 2(12) December 2006
Influenza virus particles: This negative-stained transmission electron micrograph (TEM) depicts the ultrastructural details of a number of influenza virus particles, or "virions." A member of the taxonomic family Orthomyxoviridae, the influenza virus is a single-stranded RNA organism (see Nelson et…
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Artikel Jurnal Teks lengkap
Mapping Determinants of Gene Expression Plasticity by Genetical Genomics in C. elegans
Recent genetical genomics studies have provided intimate views on gene regulatory networks. Gene expression variations between genetically different individuals have been mapped to the causal regulatory regions, termed expression quantitative trait loci. Whether the environment-induced plastic…
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Artikel Jurnal Teks lengkap
A High-Resolution Map of Synteny Disruptions in Gibbon and Human Genomes
Gibbons are part of the same superfamily (Hominoidea) as humans and great apes, but their karyotype has diverged faster from the common hominoid ancestor. At least 24 major chromosome rearrangements are required to convert the presumed ancestral karyotype of gibbons into that of the hominoid…
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Artikel Jurnal Teks lengkap
Correction: In Vivo Robustness Analysis of Cell Division Cycle in Saccharomyces cerevisiae
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Artikel Jurnal Teks lengkap
Correction: Comparative Genomics of Emerging Human Ehrlichiosis Agents
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Artikel Jurnal Teks lengkap
Functions of the Nonsense-Mediated mRNA Decay Pathway in Drosophila Development
Nonsense-mediated mRNA decay (NMD) is a cellular surveillance mechanism that degrades transcripts containing premature translation termination codons, and it also influences expression of certain wild-type transcripts. Although the biochemical mechanisms of NMD have been studied intensively, its…
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Unraveling the Genetics of Human Obesity
The use of modern molecular biology tools in deciphering the perturbed biochemistry and physiology underlying the obese state has proven invaluable. Identifying the hypothalamic leptin/melanocortin pathway as critical in many cases of monogenic obesity has permitted targeted, hypothesis-driven…
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Artikel Jurnal Teks lengkap
Prediction of Amyloidogenic and Disordered Regions in Protein Chains
The determination of factors that influence protein conformational changes is very important for the identification of potentially amyloidogenic and disordered regions in polypeptide chains. In our work we introduce a new parameter, mean packing density, to detect both amyloidogenic and disordered…
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Artikel Jurnal Teks lengkap
Stern-Judging: A Simple, Successful Norm Which Promotes Cooperation under Indirect Reciprocity
We study the evolution of cooperation under indirect reciprocity, believed to constitute the biological basis of morality. We employ an evolutionary game theoretical model of multilevel selection, and show that natural selection and mutation lead to the emergence of a robust and simple social norm…
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Targeting Neuropilin-1 to Inhibit VEGF Signaling in Cancer: Comparison of Therapeutic Approaches
Angiogenesis (neovascularization) plays a crucial role in a variety of physiological and pathological conditions including cancer, cardiovascular disease, and wound healing. Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis. Multiple VEGF receptors are expressed on…
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Correction: Stochastic Processes Are Key Determinants of Short-Term Evolution in Influenza A Virus
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Artikel Jurnal Teks lengkap
Fungal Invasion of Normally Non-Phagocytic Host Cells
Many fungi that cause invasive disease invade host epithelial cells during mucosal and respiratory infection, and subsequently invade endothelial cells during hematogenous infection. Most fungi invade these normally non-phagocytic host cells by inducing their own uptake. Candida albicans hyphae…
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