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Motor biases reflect a misalignment between visual and proprioceptive reference frames
Goal-directed movements can fail due to errors in our perceptual and motor systems. While these errors may arise from random noise within these sources, they also reflect systematic motor biases that vary with the location of the target. The origin of these systematic biases remains controversial…
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sentropy: A Python Package for Revealing Hidden Differences in Complex Datasets
Machine-learning datasets are typically characterized by measuring their size and class balance. However, there exists a richer and potentially more useful set of measures, termed S-entropy (similarity-sensitive entropy), that incorporate elements’ frequencies and between-element similarities…
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Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Human Glioblastoma Growth by Regulating Mitochondrial Function
The rapid and sustained proliferation of cancer cells necessitates increased protein production, which, along with their disrupted metabolism, elevates the likelihood of translation errors. Ribosome-associated quality control (RQC), a recently identified mechanism, mitigates ribosome collisions…
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Ethnicity and breast cancer incidence in over 329,500 women in England in 2011-2019
INTRODUCTION: Previous studies have reported an overall lower breast cancer incidence in women from Asian and Black backgrounds compared with white women. Age standardised and age specific incidence rates in the largest specific ethnicities within Asian and Black groups are not reported. MATERIALS…
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Associations of mental disorders in children with parents' subsequent mental disorders: nationwide cohort study from Finland and Denmark
BACKGROUND: Intergenerational transmission of mental disorders has been well established, but it is unclear whether exposure to a child's mental disorder increases parents' subsequent risk of mental disorders. AIMS: We examined the association of mental disorders in children with their parents'…
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Targeting SUMOylation triggers interferon-β-dependent activation of patient and allogenic Natural Killer cells in preclinical models of Acute Myeloid Leukemia
Natural Killer (NK) cells can play a significant role in the anti-tumoral immune response. In patients with Acute Myeloid Leukemia (AML), NK cells are however often found in low numbers and exhibit poor activity, contributing to leukemic progression. Allogenic NK cells are emerging as promising…
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TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis
Colorectal cancer liver metastasis (CRLM) is a major clinical problem. The regulators of immunosurveillance of CRLM could hold potential for developing therapeutic strategies to prevent or treat metastasis. Here, using a murine colorectal cancer (CRC) organoid-based transplantation mode, we…
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Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis
Half of advanced melanoma patients fail to benefit from immune checkpoint blockade and novel treatments are urgently required. Testing topical medications for anti-cancer activity in an immunotherapy-resistant murine melanoma model, we counterintuitively found that glucocorticoids elicit rapid…
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Personalized MR-Informed Diffusion Models for 3D PET Image Reconstruction
Recent work has shown improved lesion detectability and flexibility to reconstruction hyperparameters (e.g. scanner geometry or dose level) when PET images are reconstructed by leveraging pre-trained diffusion models. Such methods train a diffusion model (without sinogram data) on high-quality, but…
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Desert lizards modulate nutritional responses to match seasonal biological needs
Animals in extreme environments such as deserts experience severe seasonal fluctuations in abiotic conditions and resources. Under these conditions, they must obtain macronutrients in optimal amounts and ratios to meet their nutritional requirements, which themselves vary with seasonal changes in…
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How distinct are sleep sites from active sites across habitat types in lizards?
Sleep poses constraints, such as increased vulnerability to predators, that can lead to differences in the use of habitat components across the diel cycle. However, very few studies have systematically evaluated site use of animals across both active and sleep phases. We quantified site use during…
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Testing ethical disagreement on ancestral human remains in museums
The display of ancestral human remains in museums is a contentious ethical issue, raising concerns around the dignity and respect for ancestral lived lives versus the role of remains for education and scientific enquiry. Against the backdrop of recent debates sparked by the deinstallation of…
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Value coding by primate amygdala neurons complies with the continuity axiom of economic choice theory
The primate amygdala contributes to decision-making by encoding the subjective value of rewards, but whether these signals align with principles of economic theory remains unclear. Here, we tested compliance of amygdala value-coding with the continuity axiom of Expected Utility Theory (EUT), which…
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Strategies to Engage Systematically Marginalized Youth and Their Families in Research using High-Tech Methods
The purpose of this study was to identify facilitators and barriers for engaging youth and families from a historically and systematically marginalized community in high-tech research. Adapting community-based participatory research principles, four focus groups were conducted with 13 youth and 12…
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Variability in self-reported and biomarker-derived tobacco smoke exposure patterns among individuals who do not smoke by poverty income ratio in the United States
INTRODUCTION. Tobacco smoke exposure (TSE) among individuals who do not smoke has declined in the U.S., however, gaps remain in understanding how TSE patterns across indoor venues – including in homes, cars, workplaces, hospitality venues, and other areas – contribute to TSE disparities by income…
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How is heated tobacco product use described by people who use them daily?
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Extending patient-centred communication to non-speaking intellectually disabled persons
Patient-centred communication is widely regarded as a best practice in contemporary medical care, both in terms of maximising health outcomes and respecting persons. However, not all patients communicate in ways that are easily understood by clinicians and other healthcare professionals. This is…
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Assessing the American Public’s Preferences for Reforms to Teen Driving Licensure Systems: A Discrete Choice Experiment
OBJECTIVES: To analyze factors influencing the American public’s preferences for changes to teenage driver licensing requirements. METHODS: We employed a discrete choice experiment (DCE) with 808 participants from NORC’s AmeriSpeak panel to assess preferences for two existing elements (on-road…
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Acceptability and feasibility of video-based firearm safety education in a Colorado Emergency Department for caregivers of adolescents in firearm-owning households
BACKGROUND: Easy firearm access increases injury risk among adolescents. We evaluated the acceptability and feasibility of improving knowledge of a 3-minute safe firearm storage education video in the Pediatric Emergency Department. METHODS: We conducted a single-center block trial in a large…
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Optimizing functional connectivity scanning conditions for predicting autistic traits
Autism is a heterogeneous condition, and functional magnetic resonance imaging-based studies have advanced understanding of neurobiological correlates of autistic features. Little work has focused on the optimal brain states to reveal brain-phenotype relationships. Using connectome-based predictive…
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