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Artikel Jurnal Teks lengkap
Fz2 and Cdc42 Mediate Melanization and Actin Polymerization but Are Dispensable for Plasmodium Killing in the Mosquito Midgut
The midgut epithelium of the mosquito malaria vector Anopheles is a hostile environment for Plasmodium, with most parasites succumbing to host defenses. This study addresses morphological and ultrastructural features associated with Plasmodium berghei ookinete invasion in Anopheles gambiae midguts…
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The Fittest versus the Flattest: Experimental Confirmation of the Quasispecies Effect with Subviral Pathogens
The “survival of the fittest” is the paradigm of Darwinian evolution in which the best-adapted replicators are favored by natural selection. However, at high mutation rates, the fittest organisms are not necessarily the fastest replicators but rather are those that show the greatest robustness…
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Artikel Jurnal Teks lengkap
PLoS Pathogens Issue Image | Vol. 2(9) September 2006
Ebolavirus: Ebolavirus causes lethal hemorrhagic fever in humans. Shown in the top left and bottom right panels is a scanning electron micrograph of Ebolavirus particles emerged from a virus-infected cell, the surface of which is covered with numerous filamentous virions. The other two panels show…
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Gene Mutations and Genomic Rearrangements in the Mouse as a Result of Transposon Mobilization from Chromosomal Concatemers
Previous studies of the Sleeping Beauty (SB) transposon system, as an insertional mutagen in the germline of mice, have used reverse genetic approaches. These studies have led to its proposed use for regional saturation mutagenesis by taking a forward-genetic approach. Thus, we used the SB system…
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Genomic Environment Predicts Expression Patterns on the Human Inactive X Chromosome
What genomic landmarks render most genes silent while leaving others expressed on the inactive X chromosome in mammalian females? To date, signals determining expression status of genes on the inactive X remain enigmatic despite the availability of complete genomic sequences. Long interspersed…
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Analysis of Pleiotropic Transcriptional Profiles: A Case Study of DNA Gyrase Inhibition
Genetic and environmental perturbations often result in complex transcriptional responses involving multiple genes and regulons. In order to understand the nature of a response, one has to account for the contribution of the downstream effects to the formation of a response. Such analysis can be…
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The Many Faces of Protein–Protein Interactions: A Compendium of Interface Geometry
A systematic classification of protein–protein interfaces is a valuable resource for understanding the principles of molecular recognition and for modelling protein complexes. Here, we present a classification of domain interfaces according to their geometry. Our new algorithm uses a hybrid…
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Can Transgenic Maize Affect Soil Microbial Communities?
The aim of the experiment was to determine if temporal variations of belowground activity reflect the influence of the Cry1Ab protein from transgenic maize on soil bacteria and, hence, on a regulatory change of the microbial community (ability to metabolize sources belonging to different chemical…
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Phylogenetic Reconstruction of Orthology, Paralogy, and Conserved Synteny for Dog and Human
Accurate predictions of orthology and paralogy relationships are necessary to infer human molecular function from experiments in model organisms. Previous genome-scale approaches to predicting these relationships have been limited by their use of protein similarity and their failure to take into…
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The Genetics of Axonal Transport and Axonal Transport Disorders
Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal. The organized transport of essential biological materials throughout the neuron is required to support its growth…
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A Look to Future Directions in Gene Therapy Research for Monogenic Diseases
The concept of gene therapy has long appealed to biomedical researchers and clinicians because it promised to treat certain diseases at their origins. In the last several years, there have been several trials in which patients have benefited from gene therapy protocols. This progress, however, has…
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Three Steps to Protecting Pediatric Research Participants from Excessive Risks
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Artikel Jurnal Teks lengkap
Impact of Cyclooxygenase Inhibitors in the Women's Health Initiative Hormone Trials: Secondary Analysis of a Randomized Trial
Objectives: We evaluated the hypothesis that cyclooxygenase (COX) inhibitor use might have counteracted a beneficial effect of postmenopausal hormone therapy, and account for the absence of cardioprotection in the Women's Health Initiative hormone trials. Estrogen increases COX expression, and…
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Effect of Physical Inactivity on the Oxidation of Saturated and Monounsaturated Dietary Fatty Acids: Results of a Randomized Trial
Objectives: Changes in the way dietary fat is metabolized can be considered causative in obesity. The role of sedentary behavior in this defect has not been determined. We hypothesized that physical inactivity partitions dietary fats toward storage and that a resistance exercise training program…
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Targeted Molecular Dynamics Study of C-Loop Closure and Channel Gating in Nicotinic Receptors
The initial coupling between ligand binding and channel gating in the human α7 nicotinic acetylcholine receptor (nAChR) has been investigated with targeted molecular dynamics (TMD) simulation. During the simulation, eight residues at the tip of the C-loop in two alternating subunits were forced to…
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Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells
Hematopoietic stem cells replenish all the cells of the blood throughout the lifetime of an animal. Although thousands of stem cells reside in the bone marrow, only a few contribute to blood production at any given time. Nothing is known about the differences between individual stem cells that…
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Artikel Jurnal Teks lengkap
Temporal Regulation of Foregut Development by HTZ-1/H2A.Z and PHA-4/FoxA
The histone variant H2A.Z is evolutionarily conserved and plays an essential role in mice, Drosophila, and Tetrahymena. The essential function of H2A.Z is unknown, with some studies suggesting a role in transcriptional repression and others in activation. Here we show that Caenorhabditis elegans…
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