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Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: multicentre, randomised clinical trial
OBJECTIVE: To test the hypothesis that women assigned to a natural ovulation regimen before frozen embryo transfer compared with a programmed regimen would have an increased chance of a healthy live birth and a reduced risk of pre-eclampsia or eclampsia. DESIGN: Multicentre, randomised, parallel…
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Time trends in newly recorded diagnoses of 19 long term conditions before, during, and after the covid-19 pandemic: population based cohort study in England using OpenSAFELY
OBJECTIVE: To evaluate temporal changes in rates of newly recorded diagnoses for 19 long term conditions in England in relation to the covid-19 pandemic by disease, age group, sex, socioeconomic status, and ethnicity. DESIGN: Population based cohort study. SETTING: Primary care and hospital…
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Long term use of proton pump inhibitors and risk of stomach cancer: population based case-control study in five Nordic countries
OBJECTIVE: To help to clarify whether long term use of proton pump inhibitors is associated with an increased risk of gastric adenocarcinoma by designing a study that considered the existing literature’s methodological weaknesses. DESIGN: Population based case-control study using prospectively…
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Impact of shifting blood donation policy from gift to honour model: staggered difference-in-differences analysis in China
OBJECTIVE: To evaluate the impact of a new blood donation incentive policy—an honour model promoting blood donation quality and quantity to inform future policy changes in China and worldwide. DESIGN: Staggered difference-in-differences analysis in China. SETTING: Blood donation policies (from…
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Prediction of thyroid nodule properties and potential for malignant metastasis based on tumor pH
PURPOSE: The acidic tumor microenvironment is a specific microenvironment of malignant tumors compared to normal tissues. However, there are no reports on relevant studies such as the diagnosis and pathological staging of thyroid tumors. This study aims to explore the expression characteristics and…
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Polystyrene nanoplastics as PFAS carriers and their interactions with zwitterionic phospholipid membranes
The co-occurrence of per- and polyfluoroalkyl substances (PFAS) and nanoplastics (NPs) poses a synergistic threat to environmental and human health, yet the molecular mechanisms governing PFAS–NP complexation and membrane interactions remain unclear. Using atomistic molecular dynamics simulations…
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Electropolymerization of Au nanoparticle incorporated poly(dopamine) thin-films at a micro liquid|liquid interface
Dopamine (DA) is an important biomolecule of the central nervous system (CNS) as well as a monomer incorporated into melanin, a macromolecule often associated with skin pigmentation. Herein, we have investigated the electropolymerization of DA to form polydopamine (PDA) at a micro interface between…
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Refractory Peripheral Pulmonary Stenosis and Severe Pulmonary Arterial Hypertension Associated With a De Novo Loss‐of‐Function Variant in FGD5
We report a novel genetic variant in a patient with treatment‐resistant peripheral pulmonary artery stenosis (PPS) and progressive pulmonary arterial hypertension (PAH). A premature infant was diagnosed with bilateral PPS requiring multiple surgical reconstructions and interventional procedures…
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Individuals Adjust Their Degree of Advice Taking to Impress Others
As a form of interpersonal interaction, advice taking may occur after decision makers consider others' evaluations and impressions of them. Previous work has examined how other people view decision makers when they do or do not decide to take their advice. Our work examines whether decision makers…
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Resistin‐Like Molecule Beta Participates in Calcium Regulation Via Direct Interaction With CaSR and a PLC‐IP(3)R‐Dependent Mechanism in Hypoxia‐Induced Pulmonary Hypertension
The proliferation of pulmonary artery smooth muscle cells (PASMCs) is a key mechanism in hypoxic pulmonary hypertension (HPH). Resistin‐like Molecule Beta (RELM‐β) promotes the hypoxia‐induced proliferation of PASMCs, and calcium ions (Ca²⁺) play an important role in cell proliferation. However…
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A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN(+)) Product for Male Facial Skin: Effects on Skin Appearance and Properties
BACKGROUND: With increasing life expectancy, the aging population, particularly in Asia, is expanding rapidly. Combined with intense year‐round ultraviolet exposure, this accelerates skin aging. Male skin also exhibits distinct aging characteristics. This study aims to evaluate the efficacy and…
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Uncommon Encounter in Urachus: A Rare Case of Xanthogranulomatous Urachitis With Review of Literature
Urachus is a fibrous remnant from embryologic development derived from the allantois, which is involved in waste elimination in the fetus. Typically, it extends from the dome of the bladder to the umbilicus. Xanthogranulomatous urachitis, or xanthogranulomatous inflammation of the urachus, is a…
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Measuring sugar intake in oral health birth cohort studies: a scoping review
Numerous reviews have explored the relationship between sugar intake and various health conditions, with specific recommendations for sugar intake thresholds in medical and dental research. However, heterogeneity in dietary assessment methods used to measure sugar intake has posed challenges. This…
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Resurgence of cholera on the shores of Lake Tanganyika: security instability in eastern Democratic Republic of Congo as an aggravating factor and call to action
INTRODUCTION: The Great Lakes region in eastern Democratic Republic of Congo (DRC), currently affected by armed conflict, remains the ecological niche of Vibrio cholerae. Massive population displacement has increased population density in areas surrounding Lake Tanganyika, particularly in South…
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Analysis of high glucose injury using human induced pluripotent stem cell-derived kidney organoids
BACKGROUND: Diabetic kidney disease (DKD) is one of the most pervasive complications of diabetes worldwide. However, the pathogenesis of DKD remains poorly understood, due to limitations of the models. The hPSC-derived kidney organoids may offer a new possibility to solve the problem. METHODS: We…
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MPOX transmission risks and biosafety protocols in laboratory animal research
Mpox, known before now as monkeypox, is a novel zoonotic disease that may infect both humans and animals. It usually spreads by direct contact with bodily fluids, lesion material, or fomites (such as contaminated linens) and prolonged face-to-face contact. Mpox can spread to laboratory animals in a…
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Patient and Public Involvement and Engagement within a UK blood cancer cohort: a case study
This paper presents a case study of Patient and Public Involvement (PPI), in which people shared their ‘lived experience’ as ‘experts’ who manage their blood cancer on a daily basis, within their own environment and social circumstances. The case study is set within an ongoing cohort study that was…
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Multi-omics reveals an association of the gut butyrate-IDO1-tryptophan axis with Yinchenhaotang plus Zexietang-ameliorated NASH in a microbiota-dependent manner
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a complex metabolic disorder with limited effective treatments, and its pathogenesis involves intricate crosstalk between gut microbiota, metabolism, and host signaling. Yinchenhaotang plus Zexietang (YCHZX), a traditional Chinese medicine (TCM)…
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PRESCO: an online tool for predicting severe pulmonary complications and survival after cancer surgery
BACKGROUND: Severe pulmonary complications (SPCs) after cancer surgery have a significant impact on morbidity, mortality, and healthcare burden. Despite this, clinicians currently lack accurate and practical tools to predict the occurrence and survival outcomes of SPCs. METHODS: We conducted a…
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Nuclear cell-free DNA on the loose: an early warning signal of ischemia–reperfusion injury in kidney transplantation
INTRODUCTION: Cell-free DNA is an emerging marker of allograft injury, yet its role in the immediate phase of ischemia–reperfusion injury remains incompletely understood. METHODS: In this prospective cohort of 127 kidney transplant recipients (86 deceased donors, 41 living donors), intraoperative…
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