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Artikel Jurnal Teks lengkap
Validation and normative data for a new dynamic instrument evaluating phonological processing skills in Italian first-grade students
INTRODUCTION: Phonological processing skills are fundamental to children's language development and academic success. There is an increasing need for assessment tools that can reliably identify difficulties in these areas at the beginning of primary school. This concerns both children already…
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Metabolomic profiling of varicocele-induced male infertility: insights from spermatic vein blood analysis
OBJECTIVE: Varicocele (VC) is a leading cause of male infertility, but its pathophysiological mechanisms remain inadequately defined. This study aimed to characterize metabolic alterations in spermatic vein blood of varicocele patients with/without infertility (VI/VF groups) compared to healthy…
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Artikel Jurnal Teks lengkap
Extra-pancreatic solid pseudopapillary neoplasm: a case report of primary testis origin and review of the literature
Solid pseudopapillary neoplasm (SPN) is a rare tumor with low malignant potential, generally occurring in the pancreas. In this article, we report a case of extra-pancreatic solid pseudopapillary neoplasm of the testis (ESPN-T) of a 36-year-old male patient. The patient incidentally discovered a…
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Artikel Jurnal Teks lengkap
The role of impaired adipogenesis in insulin resistance among non-obese individuals
INTRODUCTION: Adipogenesis is an essential process for energy storage, hormone regulation, and overall metabolic health. Previous work showed that impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance. This project investigates the role of…
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Artikel Jurnal Teks lengkap
The role of neuroendocrine differentiation in treatment resistance of prostate cancer and intervention strategies
Prostate cancer is one of the most common malignancies in men, and resistance to conventional treatments is frequently encountered in clinical practice. Among the mechanisms contributing to this resistance, neuroendocrine differentiation (NED) is particularly significant. NED does not only change…
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Artikel Jurnal Teks lengkap
Brain fog in Parkinson’s disease: unraveling mechanisms and measuring impact
Inconsistent colloquial and professional uses of the term “brain fog” have undermined the potential for empirical study of this symptom complex, and there is no consensus about how to diagnose or treat it. Yet brain fog is frequently reported by patients with post-acute sequelae of SARS-CoV-2…
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Artikel Jurnal Teks lengkap
Glutamate metabotropic receptor 4 in breast cancer: a potential and specific target for chimeric antigen receptor therapy
BACKGROUND: Despite the revolutionary success of chimeric antigen receptor (CAR) therapy in hematologic malignancies, its application in solid tumors is hindered by the scarcity of tumor-specific membrane antigens rigorously validated in clinical specimens. Here, we identified glutamate…
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Editorial: Molecular mechanisms of the host immune response to Toxoplasma gondii infection
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Artikel Jurnal Teks lengkap
Case Report: Trastuzumab deruxtecan in human epidermal growth factor receptor 2-mutated lung cancer with continuous renal replacement therapy
BACKGROUND: Human epidermal growth factor receptor 2 (HER2)-mutated lung cancer is a rare and aggressive subtype of non-small cell lung cancer (NSCLC), characterized by poor prognosis and limited response to conventional therapies. Trastuzumab deruxtecan (T-DXd), a HER2-targeting antibody-drug…
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Predictive value of temporal muscle thickness in patients with chronic subdural hematoma
BACKGROUND: Chronic subdural hematoma (CSDH) is a common neurosurgical condition that predominantly affects elderly individuals and is characterized by the accumulation of blood between the dura mater and the brain surface. Temporal muscle thickness (TMT) has emerged as a potential prognostic…
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Artikel Jurnal Teks lengkap
Deciphering obesity: a conceptual overview and synthesis
Obesity represents a multifactorial disorder rooted in genetic, developmental, and environmental influences. Its persistence and heterogeneity warrant deeper understanding of pathology beyond genetic determinism. This Perspective synthesizes a conceptual model that draws from fundamental concepts…
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Artikel Jurnal Teks lengkap
Functional toll-like receptor 4 links endotoxin sensing to platelet priming in feline platelets
OBJECTIVE: To characterize toll-like receptor 4 (TLR4) expression in feline platelets and to assess the priming potential of Escherichia coli lipopolysaccharide (LPS) in the presence or absence of physiologic agonists. In addition, the downstream effects of TLR4 activation on arachidonic acid…
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Early warning model for depression and anxiety among adolescent students: an empirical study based on Guilin
OBJECTIVE: To analyze the occurrence of depression and anxiety in Guilin and verify the early warning model of depression and anxiety in Guilin. METHODS: Using multi-layer sampling method, 10 middle schools were selected from September 2022 to September 2023, with a total of 1,245 middle and high…
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Artikel Jurnal Teks lengkap
Diabetes and tumor risk: a 23-year Danish national cohort study
INTRODUCTION: Diabetes mellitus is a recognized risk factor for cancer, yet the relationship between diabetes type and tumor risk remains unclear. This study aimed to estimate the overall tumor burden, including benign, premalignant, and malignant tumors, in individuals with type 1 and type 2…
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Artikel Jurnal Teks lengkap
Weight analysis of Chinese nurses' behaviors to maintain patient dignity and its relationship with job-esteem: a cross-sectional study controlling for agreeableness
BACKGROUND: Patient dignity is fundamental to nursing ethics and care quality, yet nurses often face challenges in upholding it. This study examines how nurses' Job-Esteem influences their behaviors for maintaining patient dignity in China. METHODS: This two-stage study was conducted in 2025. The…
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Artikel Jurnal Teks lengkap
Effect of ethylene-vinyl acetate and rubber waste on asphalt concrete performance
The performance of asphalt concrete under increasing traffic loads and varying climatic conditions necessitates the development of enhanced bituminous binders. Some additives used as asphalt modifiers are polymeric materials. Examples of these polymers are styrene-butadiene rubber latex (SBR)…
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Artikel Jurnal Teks lengkap
Effect of treatment duration on the associations between three modern antidiabetic drugs and survival outcomes of lung cancer in China
BACKGROUND: Some antidiabetic drugs have been shown to have tumor suppressor or activator properties. The associations between the treatment durations of three relatively new classes of antidiabetic medications, namely glucagon-like peptide-1 receptor agonists (GLP-1RA), dipeptidyl peptidase 4…
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Artikel Jurnal Teks lengkap
Exploring the impact of age, sex and life experiences on plasma inflammatory profiles through comparative proteomics
BACKGROUND: In the heterochronic parabiosis model it has been shown that blood from elderly animals exhibits markedly reduced rejuvenating effects compared to that of young organisms. Furthermore, human plasma from older subjects, when used as a supplement in cell culture media, is significantly…
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Chrononutrition interventions for mental health: addressing atypical depression, ultra-processed food use disorder, and circadian dysregulation
BACKGROUND: Atypical depression frequently presents with metabolic and immuno-inflammatory comorbidities, often exacerbated by chronic intake of ultra-processed foods (UPFs), which can exhibit addictive-like properties. However, these dietary underpinnings are rarely a focus in standard psychiatric…
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Artikel Jurnal Teks lengkap
Ultrasound-guided sclerotherapy with 76% meglumine diatrizoate for bilateral chylothorax after thyroid cancer surgery: a case report
Bilateral chylothorax following thyroid cancer surgery is exceedingly rare, and management becomes more challenging when one side presents as high-output (>1,000 mL/day). Conservative treatments often yield limited success. We report a case of recurrent papillary thyroid carcinoma in which…
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