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Temporal profiling of haptoglobin and cytokines in feedlot cattle with bovine respiratory disease
Inflammatory cytokines and haptoglobin (HPT) were measured from 28 head of cattle that presented with bovine respiratory disease after being purchased and shipped to a common feedlot and assigned to either control or metaphylaxis treatment groups. Blood samples were obtained on the day of purchase…
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A real-world study on clinical features and prognosis of Chinese breast cancer patients with brain metastases
BACKGROUND: This study aimed to analyze the clinical characteristics and prognosis of breast cancer (BC) patients with brain metastases (BM). METHODS: We performed a retrospective analysis of breast cancer patients with brain metastases (BCBM) in a real-world setting. RESULTS: In a cohort of 249…
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Plant genomic and microbial interplay in the rhizosphere under salt stress: a review
Soil salinization has been considered as a global problem in agriculture, which decreases crop productivity and threatens food security. Salt stress causes complex physiological damages in plants such as ionic imbalance, osmotic stress, and oxidative damage. However, plants have developed several…
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Developing a Gender Equity, Diversity, and Inclusivity (GEDI)-responsive curriculum framework for Philippine higher education: a qualitative case study of faculty perspectives
INTRODUCTION: Gender Equity, Diversity, and Inclusivity (GEDI) have become essential components of higher education reform; however, their integration into Philippine higher education curricula remains inconsistent. Thus, this study explored GEDI faculty members’ perspectives on integrating GEDI…
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Machine learning-based approach to guide the choice between baricitinib and tocilizumab in critical COVID-19 pneumonia treatment: a retrospective cohort study
INTRODUCTION: Clear guidance on choosing baricitinib (BCT) or tocilizumab (TCZ) for critical COVID-19 pneumonia remains limited. We developed machine-learning (ML) models to inform immunomodulator selection. METHODS: We curated clinical data from patients with critical COVID-19 pneumonia admitted…
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Breaking ground: insights from a WHO-approved surgical mission amid Sudan's healthcare collapse
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Reduction of insulin resistance in 14–15-year-old students after the COVID-19 pandemic: a prospective study from Tsunan, Japan
INTRODUCTION: A significant increase in HOMA-IR values has been reported in children after the COVID-19 pandemic. This study aimed to investigate how the changes of HOMA-IR after COVID-19 was post-pandemic (2023–2024). MATERIALS AND METHODS: The study included 462 students aged 14–15 from Tsunan…
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Impact of BMI on basal LH in premenarcheal girls with idiopathic central precocious puberty
AIM: To examined whether body mass index (BMI) affects basal gonadotropin secretion in premenarcheal girls with idiopathic central precocious puberty (ICPP). METHODS: This retrospective single-center study involved girls diagnosed with ICPP. They were classified into underweight, normal weight…
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Policies and strategies on active and healthy ageing: a scoping review of the recommendations of European and international agencies
BACKGROUND: Over the past six decades, life expectancy has significantly increased, with a concurrent decline in fertility rates, leading to unprecedented demographic shifts. These changes have deeply changed population structures and presented challenges for welfare systems, particularly regarding…
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Hemi-precession maneuver to treat horizontal canal benign paroxysmal positional vertigo when the affected side is unilateral, bilateral or unknown
Benign paroxysmal positional vertigo (BPPV) is the most common cause of dizziness over the lifespan. The second most commonly affected semicircular canal in BPPV is the horizontal canal, which poses a diagnostic problem and two therapeutic problems. The diagnostic problem is the difficulty of…
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Machine learning-based online prediction of nocturnal hypoglycemia in elderly patients with type 2 diabetes
CONTEXT: Nocturnal hypoglycemia (NH) is a common adverse event in elderly patients with type 2 diabetes (T2D). This study aims to develop a clinically applicable model for predicting the risk of NH in elderly patients with T2D. METHODS: This retrospective cohort study, conducted from May 2018 to…
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Citizenship formation and resilience among Ukrainian female migrants: case studies from Norway
INTRODUCTION: The escalation of the armed Russian/Ukraine conflict in 2022 precipitated a significant humanitarian crisis. The ensuing forced migration, trauma, and family separation presented complex challenges, particularly for women. This study aims to understand complex social phenomena through…
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Comparison of the efficacy of antidiabetic agents in type 2 diabetes with MASLD: a network meta-analysis
OBJECTIVE: To evaluate and compare the efficacy of different antidiabetic agents in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes mellitus (T2DM). METHODS: We systematically searched PubMed, Embase, the Cochrane Library, and Web of Science for…
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High intra-tumoral and serum matrix metalloproteinase 9 levels are associated with reduced survival of patients with glioblastoma and brain metastases
PURPOSE: Matrix metalloproteinase 9 (MMP-9) has been shown to promote glioblastoma invasion and the spread of brain metastases (BM). However, the current literature on its link to patient survival is inconsistent. This study examines intra-tumoral and sera MMP-9 levels and their correlation with…
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Protocol for a randomized controlled trial evaluating the artificial intelligence health education accurately linking system in patients with mild-to-moderate stroke
BACKGROUND: Stroke is a leading cause of death and disability worldwide. Although survival rates from mild-to-moderate stroke are high, long-term functional impairment remains common, requiring sustained self-management beyond traditional rehabilitation. Conventional models depend on institutional…
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Stay-green trait improves yield, quality, and feeding value of forage oats under contrasting eco-sowing systems
INTRODUCTION: Oat (Avena sativa L.) is an important food and forage crop whose yield and quality are influenced by genotype, environmental conditions, and sowing regimes. The stay-green (SG) trait, which delays leaf senescence and maintains photosynthetic capacity, can enhance yield and forage…
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Long-term annual trends in suicide rates and characteristics of suicide cases in prisons in Japan
This study aims to investigate suicide mortality rates and their time trends in prisons against the national level and related facilities, and to identify characteristics of suicide cases in Japan. The study design of this study was a nationwide cross-sectional study. It targeted prisoners and…
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Development and validation of a prognostic nomogram for predicting hypostatic pneumonia risk in large vessel occlusion stroke after endovascular therapy patients
BACKGROUND: Post-stroke hypostatic pneumonia (HP) significantly impairs neurological recovery and worsens prognosis in patients with acute ischemic stroke with large vessel occlusion (AIS-LVO). This study aimed to develop and validate a prognostic nomogram for predicting hypostatic pneumonia risk…
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Measuring health-related quality of life in Africa: a systematic review of validated disease-specific and generic measurement tools
BACKGROUND: This systematic review examines the evidence on the use of health-related quality of life (HRQoL) tools for African populations and evaluates their psychometric properties, cultural adaptation, and applicability. METHODS: A systematic search was conducted across PubMed, Web of Science…
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