11.943.971 hasil
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An overview of hypopituitarism’s causes
The widespread application of tumor therapies such as immune checkpoint inhibitors and the emergence of new infectious diseases such as COVID-19 are promoting the continued expansion of the cause spectrum of hypopituitarism, making its scope significantly beyond traditional causes such as pituitary…
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TBX21 correlates with an immunosuppressive tumor microenvironment and Treg/Th17 imbalance in prostate cancer
BACKGROUND: Prostate cancer (PCa) remains a major health burden, and identifying target molecules will provide new research ideas for treating PCa. TBX21 is a transcriptional factor with critical functions in tumor development, roles of which in PCa were studied herein. METHODS: TBX21 expression…
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Sensor-based quantification of items used in the MDS-UPDRS-III scale: repetitive lower-limb movements in healthy human participants
BACKGROUND: The Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) is used as a standardized approach to assess motor function in Parkinson’s disease (PD). This assessment is based on the examiner’s subjective judgement and is therefore variable. While quantitative…
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Case Report: Pembrolizumab associated lichen planus in early stage triple negative breast cancer
Triple negative breast cancer (TNBC) is a breast cancer with a poor prognosis, marked by the absence of estrogen (ER) and progesterone (PR) receptors as well as human epidermal growth factor receptor (HER2) expression. Although TNBC is characterized by a high recurrence rate and poorer survival, it…
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Characteristics of dysarthria in patients with spinocerebellar degeneration and multiple system atrophy: a cross-sectional and longitudinal study using the Frenchay Dysarthria Assessment Second Edition (FDA-2)
PURPOSE: The purpose of this study was to evaluate the dysarthria of patients with spinocerebellar degeneration and multiple system atrophy (SCD/MSA) cross-sectionally and longitudinally using the Frenchay Dysarthria Assessment Second Edition (FDA-2), which provides a comprehensive assessment of…
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Immunological testing and machine learning in detecting latent tuberculosis among high-risk groups (nature review)
INTRODUCTION: Tuberculosis infection remains one of the most dangerous and difficult to diagnose diseases. To date, issues related to the early diagnosis of tuberculosis remain unresolved, which is particularly important for its detection in high-risk groups. The detection of latent tuberculosis…
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SWE, C-TIRADS and AI-assisted diagnostic systems in distinguishing thyroid nodules of different lesion size: Which has better diagnostic performance?
OBJECTIVE: To compare the diagnostic performance of shear wave elastography (SWE), Chinese Thyroid Imaging Reporting and Data System (C-TIRADS), and an artificial intelligence (AI)-assisted diagnostic system in differentiating thyroid nodules of different sizes. METHODS: A total of 103 thyroid…
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Transplanted gene-modified placental cells boost FVIII activity in pediatric sheep without eliciting immunity, toxicity, or adverse events
BACKGROUND: The current standard of care for Hemophilia A (HA), a hereditary bleeding disorder caused by mutations in the Factor VIII (F8) gene, include FVIII replacement proteins, engineered clotting factors, and a broad array of new therapeutics including antibodies and gene therapy. These…
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Mitochondrial dynamics in cisplatin resistance: molecular mechanisms and therapeutic targeting
Cisplatin remains a cornerstone of chemotherapy for numerous cancers, despite the persistent challenges of toxicity and the development of drug resistance. Therefore, a deeper understanding of the mechanisms behind cisplatin resistance and the development of strategies to counter it are of critical…
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Development and validation of multiple machine learning algorithms for differentiating primary central nervous system lymphoma from adult-type diffuse glioma: an interpretable and multicenter study
BACKGROUND: Preoperative differentiation of primary central nervous system lymphoma (PCNSL) from adult-type diffuse glioma(ADG) is important to guide neurosurgical decision-making.To develop and validate a MRI–based interpretable radiomic-clinical(Rad-Clinic) fusion model to differentiate PCNSL…
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Molecular mechanisms of streptococcal disruption of the blood-brain barrier and their pathogenic role in bacterial meningitis
Bacterial meningitis represents a devastating inflammatory disease of the central nervous system (CNS), characterized by the invasion of pathogens across the blood-brain barrier (BBB) and subsequent dysregulated immune responses. Key inflammatory mechanisms include pathogen recognition by…
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The impact of department chair leadership identity on faculty thriving in comprehensive university reform: the cross-level moderating role of work arrangement flexibility
INTRODUCTION: As universities undergo intensifying reform pressures, department chairs face the challenge of balancing administrative duties with academic mentorship; how they internalize their leadership role—their leadership identity—may critically shape faculty outcomes, yet this internal driver…
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Association between vancomycin therapeutic drug monitoring and improved clinical outcomes in critically ill patients receiving renal replacement therapy: a retrospective cohort study
INTRODUCTION: Vancomycin is commonly prescribed for serious infections in critically ill patients. A substantial proportion of these individuals present with renal impairment or develop acute kidney injury (AKI), and some may require renal replacement therapy (RRT). Different RRT modalities can…
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Metabolism, senescence, and natural products: new perspectives on wound healing in diabetes
Chronic diabetic wounds have become a major clinical challenge because of their difficulty in healing and high recurrence rate. This review proposes for the first time the theoretical framework of the “metabolism–senescence axis,” systematically elucidating the central role of cellular senescence…
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Association between advanced lung cancer inflammation index levels and ischemic stroke in patients with atrial fibrillation: a propensity score-matching analysis
INTRODUCTION: Inflammation is closely associated with atrial fibrillation (AF) complicated by stroke. The Advanced Lung Cancer Index (ALI) is a comprehensive indicator of inflammation; however, its relationship with AF-related stroke is unclear. Therefore, this retrospective study was conducted to…
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Hypoxia-induced immunosuppression in uveal melanoma is mediated by CD63(+) exosomes delivering lactate to reprogram immune cells
Uveal melanoma (UM) is characterized by profound immunosuppression, resistance to immunotherapy, and significant hypoxia. This study investigates the role of hypoxia in mediating metabolic crosstalk with immune cells via CD63-enriched exosomes. Single-cell transcriptomic analysis identified a…
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So you think you can dance? Development and validation of the Dance Self-Efficacy Scale for older adults (DanSES-60+) for research and practice
BACKGROUND: Dance and movement represent a recommended form of exercise for older adults that benefits health across diverse cultures and socioeconomic groups. Individual differences in dance self-efficacy may be key determinants of participation in dance for health programs, yet existing measures…
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Clinical outcomes of endovascular treatment for acute basilar artery occlusion patients with extremely severe symptoms
OBJECTIVE: This study aimed to investigate the effectiveness and safety of endovascular treatment (EVT) in acute basilar artery occlusion (ABAO) patients with extremely severe symptoms [National Institutes of Health Stroke Scale (NIHSS) score >25] in the real world. METHODS: This study was a…
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Hyperoside ameliorates lupus nephritis by suppressing AKT1-mediated PANoptosis in podocytes: integrating network pharmacology and experimental validation
BACKGROUND: Lupus nephritis (LN), one of the most common and severe complications of systemic lupus erythematosus (SLE), remains challenging to treat due to its complex pathogenesis. Hyperoside (Hyp), a naturally occurring flavonol glycoside and a key active component in numerous Chinese medicines…
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