11.943.971 hasil
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Artikel Jurnal Teks lengkap
Predictive coding and neurocomputational psychiatry: a mechanistic framework for understanding mental disorders
Predictive coding offers a powerful computational framework for understanding brain function and psychiatric disorders at a mechanistic level. This perspective synthesizes advances in computational psychiatry, proposing that mental disorders can be conceptualized as specific alterations in the…
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One health and human animal-bond intervention strategies- assessing veterinary-social service collaborations
This study evaluates a novel interdisciplinary outreach model integrating veterinary care, social work, and public health services to serve unhoused populations and their companion animals in Topeka, Kansas. Grounded in structural vulnerability theory and One Health principles, the project examined…
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Horizontal head-shaking test: pathophysiological mechanisms and clinical interpretation
The horizontal head-shaking test (HST) is a simple, rapid, and non-invasive bedside maneuver that provides valuable insights into both peripheral and central vestibular function. Originally described in the late 19th century and standardized in the 1970s, the HST predominantly stimulates the…
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Deep exploration and precise identification of key risk factors for diabetic peripheral neuropathy using the random forest algorithm
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a prevalent and highly disabling complication of diabetes mellitus, associated with markedly increased rates of disability and mortality. Timely intervention and effective management have been consistently shown to substantially reduce the risk of…
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Tight cultures as a double-edged sword for burnout: the job demands-resources perspective on perceived organizational tightness and the moderating effect of gender
INTRODUCTION: Although research on cultural tightness—the extent to which groups enforce strict norms and tolerate few deviations—reveals mixed effects on wellbeing, most existing evidence comes from national or regional contexts. Yet the dynamics inside organizations are distinct and warrant…
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Prevalence of vitamin D deficiency and related factors among adults in Tokat province, Türkiye: a community-based cross-sectional study
BACKGROUND: Vitamin D deficiency is a major public health concern, worldwide yet data on the adult population in Türkiye remain limited. This study aimed to determine the prevalence of vitamin D deficiency and its associated risk factors in Tokat Province, Türkiye. METHODS: A population based…
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Refined pharmacovigilance assessment of immune checkpoint inhibitors-related bullous pemphigoid: a multi-methodological approach utilizing FAERS database
OBJECTIVES: To evaluate the potential risk of bullous pemphigoid (BP) in patients treated with immune checkpoint inhibitors (ICIs) and to characterize ICI-related BP (irBP) using the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database. METHODS: The present…
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Preoperative Botulinum Toxin for Complex Diaphragmatic Paralysis: A Case Series
INTRODUCTION: The management of giant diaphragmatic paralysis remains a significant surgical challenge, frequently associated with high rates of recurrence and the risk of developing abdominal compartment syndrome. While the use of Botulinum Toxin Type A (BTX- A) as an adjuvant therapy has been…
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A Brief Review of Artificial Intelligence in Living Kidney Donation
Artificial intelligence (AI) is rapidly transforming healthcare, and the field of kidney transplantation (KT) is no exception. While much of the AI-related work has focused on deceased donor KT, there is a growing body of research applying AI tools to living kidney donation (LKD). This review…
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Digitally derived Ki-67 proliferation index for GastroEnteroPancreatic neuroendocrine neoplasms
Ki-67 proliferation indices (PIs) define the grading of GastroEnteroPancreatic NeuroEndocrine Neoplasms (GEPNENs) and are crucial for therapeutic decisions. The precise Ki-67 assessment relies on manual counting, which is time-consuming, hardly accessible during routine pathological signout and…
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“Patient-specific plates: Anatomical precision, economic exclusion?”
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Artikel Jurnal Teks lengkap
Mapping the Dynamic Complexity of Hypertension Management in São Paulo, Brazil
OBJECTIVES: Hypertension is a major cardiovascular risk factor in Brazil and globally, requiring effective healthcare system strategies. This study examines how the health system in São Paulo manages hypertension, identifying patterns and connections that influence patient outcomes and resource…
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Enhancement of oral bioavailability of risedronate through xyloglucan rafts
Bisphosphonates irritate the stomach and oesophagus and have a very limited absorption. The purpose of this study was to increase risedronate (RDN) oral bioavailability by causing a raft to form in the stomach. The creation of a raft prevents the irritation of the stomach and oesophagus caused by…
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Explore thyself: is it time for metacognition screening in clinical trials?
Participant self-report has become increasingly important in the design of clinical trials for Parkinson’s Disease (PD), resonating with the general sense that a person’s account of their experience should be a prime consideration in evaluating the effects of therapeutics. Typical study designs…
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Comparative evaluation of static and dynamic 4D dose recalculations in pencil beam scanning proton therapy for oesophageal cancer
BACKGROUND AND PURPOSE: The robustness of pencil beam scanned (PBS) proton plans to respiratory motion is often assessed in clinical practice by static 4D dose recalculations on selected 4D computed tomography (4DCT) phases. These capture anatomical variation but neglect interplay effects from…
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Intrinsic capacity and risk of hip fracture in older adults: evidence from five multinational aging cohorts
BACKGROUND: Hip fracture poses a substantial threat to the quality of life in older adults. Evidence regarding the association between intrinsic capacity (IC) and hip fracture is limited. This study aimed to investigate the relationship between IC and hip fracture risk in older populations…
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Evaluation of the diagnostic value of metagenomic next-generation sequencing for zoonotic cestode Spirometra mansoni infection
Metagenomic next-generation sequencing (mNGS) technology offers substantial advantages in parasite detection; however, we still know very little about its diagnostic value for Spirometra mansoni infection. In this study, mNGS technology was used to analyse faecal samples and blood samples from cats…
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Legal framework reform imperatives for rabies elimination in Bangladesh
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Artikel Jurnal Teks lengkap
Application of ultrasound and ultrasound-responsive materials in wounds: A systematic review
Wound healing is a multifaceted biological process that is highly susceptible to disruption by numerous internal and external factors, resulting in delayed tissue repair. Recent advancements have highlighted the therapeutic potential of ultrasound, especially when integrated with emerging smart…
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Artikel Jurnal Teks lengkap
Associations of volatile organic compound exposure with phenotypic age acceleration and the synergistic interaction of dietary micronutrients
OBJECTIVE: This study assesses the association between exposure to volatile organic compounds (VOCs) and phenotypic age acceleration, and evaluates the potential synergistic interaction by dietary micronutrient intake. METHODS: A total of 7,209 participants were chosen from the National Health and…
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