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Associations Between the Cardiovascular Health Diet Index (CHDI) and Cardiometabolic Risk Factors in Brazilian Workers: A Cross‐Sectional Study
BACKGROUND: The Cardiovascular Health Diet Index (CHDI) was recently developed to assess compliance with dietary recommendations aimed at preventing cardiovascular disease and promoting cardiovascular health on a population level, based on guidance from the American Heart Association (AHA) and…
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Diet and Dental Caries in Elite Athletes in Ireland
OBJECTIVES: This study assessed dental caries prevalence and dietary habits among elite athletes in Ireland, and analysed dietary intake with particular focus on potentially cariogenic foods and nutrients to determine associations between potentially cariogenic dietary factors and dental caries…
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Replacing the Classics? A Comparison of the ERPs Evoked by IAPS and OASIS Images During Emotional Processing
Emotional visual stimuli presented in laboratory settings reliably elicit prototypical patterns of subjective and psychophysiological responses. These responses likely serve distinct functions and reflect the engagement of appetitive and defensive motivational systems, making them a valuable tool…
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Impacts of urban adaptation on reducing temperatures and heat-related deaths in Belgium
Extreme heat poses increasing risks to urban populations, yet the effectiveness of adaptation strategies at larger scales beyond neighbourhoods remains poorly quantified. The July 2019 heatwave in northwestern Europe, one of the hottest on record, offers a unique opportunity to evaluate city- and…
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Prenatal exposure to acrylamide and metabolic health at 20 years of age A biomarker-based Danish cohort study
Adult obesity and metabolic health may be influenced by prenatal exposure to acrylamide (AA). AA forms in carbohydrate-containing foods and beverages during high-temperature processing. AA disrupts metabolic homeostasis and induces adiposity in mice offspring following gestational exposure. In…
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The race between 4-1BB- and CD28-based CD19 CAR-T products in the therapy of B-cell malignancies
Chimeric antigen receptor T-cell (CAR-T) therapy targeting CD19 has revolutionized the treatment of B-cell malignancies. One of the critical factors influencing CAR-T efficacy and durability is the costimulatory domain, with 4-1BB and CD28 emerging as the two dominant signaling platforms. While…
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On the use and misuse of pangenome and related terms
The growth of pangenomics has been rapid, as data and tools improve over time. However, care should be taken to avoid the misuse of pangenome and related terms, with clarity and precision taking precedent over fashion and trends.
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Exploring health consequences of Asthma-COPD overlap syndrome in a national study
Asthma-COPD overlap syndrome (ACOS) represents a clinically significant yet under characterized respiratory phenotype. Comprehensive population-based assessments of ACOS-attributable burden, smoking dose-response relationships, phenotypic subtypes, and mechanistic pathways remain limited. Using…
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Biosynthesis of silver nanoparticles via Melaleuca alternifolia leaf extract for antibacterial, antifungal, antioxidant and anticancer activity
Synthesis of silver nanoparticles using the leaf extract of Melaleuca alternifolia (M-AgNPs), as evidenced by various physicochemical characterizations, including UV-Visible spectroscopy (UV-Vis), Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), X-ray diffraction…
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Addressing general measurements in quantum Monte Carlo
Quantum Monte Carlo is one of the most promising approaches for dealing with large-scale quantum many-body systems. It has played an extremely important role in understanding strongly correlated physics. However, two fundamental problems, namely the sign problem and general measurement issues, have…
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High-efficiency femtosecond laser fabrication of graphene-hybrid planar micro-supercapacitors with micro/nanostructured electrodes
The integration of surface-regular micro/nanostructured electrodes within a limited footprint area is promising to enhance the electrochemical performance of planar micro-supercapacitors (P-MSCs), while developing simple yet efficient manufacturing methods for such electrodes remains a challenge…
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A detachable crawling robotic hand
The human hand is often viewed as the pinnacle of dexterity, and many robotic hands adopt anthropomorphic designs, while others pursue non-anthropomorphic forms for structural balance or task optimization. However, human-like asymmetry and reliance on a single thumb limit applications that require…
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Lack of concordance among infant social attention measures
Infants’ tendency to focus on socially relevant cues is commonly referred to as ‘social attention’ and is often conceptualized as a unified construct. However, few studies have examined the concordance among measures that fall under this label. In this study, we assessed 50 ten-month-old infants…
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IGF2BP3-dependent glutamine/BCAA metabolic rewiring rejuvenates aged human adipose-derived stem cells for enhanced tissue regeneration
Aging impairs the regenerative capacity and differentiation potential of human adipose-derived stem cells (hASCs), but the mechanisms underlying their functional decline remain unclear. Through systematic functional assays and in vivo experiments, we first confirmed age-associated reductions in…
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Morphological evolution indicates the transformation of stress interference in parallel fractures
Fracture propagation is ubiquitous in natural strata and geological engineering, influencing key processes such as engineering stability assessment and design optimization. While prior studies have investigated the propagation of individual fractures through gelatin experiments, stress interference…
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The pseudouridine synthase PUS7 is associated with stemness and represents a potential therapeutic target in triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) represents a highly aggressive subtype of breast cancer characterized by increased recurrence rates and poor prognosis, primarily due to the lack of effective therapeutic targets. Pseudouridine synthases (PUSs) are a class of enzymes that are responsible for…
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5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer
BACKGROUND: Early cancer detection has the potential to significantly improve treatment outcomes and survival rates. This study investigates the roles of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA…
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Labour market patterns among women and men following the uptake of their first parental leave benefit in Sweden
This study identified long-term labour market patterns after taking the first parental leave benefit among women and men in Sweden and the socio-demographic, economic, and health-related characteristics among the identified patterns. We conducted a prospective cohort study, based on nationwide…
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Real-time semantic segmentation of driving scenes via effective attention-based information fusion and hybrid encoder
Real-time semantic image segmentation approaches require two important properties that should be addressed simultaneously, i.e., extremely accurate segmented outputs and high inference speed. Nonetheless, the semantic segmentation field is dominated by complex deep learning architectures that focus…
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Multiomics Mendelian randomization identifies serpin family G member 1 as a chronic obstructive pulmonary disease modulator
Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide, lacks effective disease-modifying therapies, partly because of complex gene–environment interactions and extensive missing heritability. Here, we applied a multiomics Mendelian randomization (MR)…
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