11.943.971 hasil
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Artikel Jurnal Teks lengkap
The association of frailty with health care costs using the FRAIL scale
BACKGROUND: The self-reported FRAIL scale is suitable for frailty assessment in the busy primary care practice setting. AIM: To estimate the association between phenotypic frailty assessed by FRAIL and subsequent health care costs in older men and women. METHODS: Prospective study of 7947…
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Analysis of the Relationship Between Chemical Elements and Neural Necrosis Virus in Mugilids from the Southern Caspian Sea
For years, the Caspian Sea has been affected by chemical pollution resulting from human activities. More recently, Viral Nervous Necrosis (VNN) has emerged as a new threat, severely impacting fish populations in this aquatic ecosystem. The aim of this study was to evaluate differences between…
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Global burden of non-Hodgkin lymphoma in the elderly: a population-based study using GBD 2021
Elderly people are facing an increasing burden of non-Hodgkin lymphoma. However, accurate information on the NHL burden among elderly people remains limited. On the basis of the Global Burden of Diseases 2021, we described the global burden of non-Hodgkin lymphoma in people aged ≥ 65 years and…
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Vascular complications in NPM1-Mutated acute myeloid leukemia: clinical features and prognosis
Although nucleophosmin 1 (NPM1) mutation is generally considered a favorable prognostic biomarker in acute myeloid leukemia (AML), its clinical behavior is heterogeneous. A subset of NPM1-mutated patients continues to experience adverse outcomes despite their favorable genotype. We conducted a…
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Blinatumomab exposure prior to allogeneic stem cell transplantation is associated with increased Epstein-Barr virus reactivation
Blinatumomab, a CD19/CD3 bispecific T-cell engager, is frequently used for B-cell acute lymphoblastic leukemia (B-ALL) prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although its efficacy in achieving measurable residual disease negativity is well established, its profound…
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Role of MRI radiomics in deep learning-based prediction of intestinal diseases
BACKGROUND: Magnetic resonance imaging (MRI) is widely used for the diagnosis, evaluation, and follow-up of intestinal diseases. With advances in artificial intelligence, MRI radiomics and deep learning have emerged as promising tools for prognostic assessment and treatment guidance. This review…
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Comparative chemical and biological study of essential oils and n-hexane extracts of Thymus vulgaris and Thymus serpyllum (Lamiaceae)
This study presents a comparative chemical and biological evaluation of essential oils (EOs) and n-hexane extracts from Thymus vulgaris and Thymus serpyllum (Lamiaceae), alongside a reference commercial thyme oil. GC-MS analysis revealed significant differences in chemical composition among the…
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Detection and characterization of Candidatus mycoplasma haemolamae haplotype in South American camelids farmed in Italy
‘Candidatus Mycoplasma haemolamae’ (CMhl) is a hemotropic bacterium infecting South American Camelids (SAC), whose epidemiology and clinical significance are still not fully elucidated. This study investigated CMhl by qPCR in blood samples of alpacas (Vicugna pacos) and llamas (Lama glama) in Italy…
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Correction: Grape-seed Polyphenols Play a Protective Role in Elastase-induced Abdominal Aortic Aneurysm in Mice
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Artikel Jurnal Teks lengkap
Cross-cultural structures of personal name systems reflect general communicative principles
The structure of personal names appears to differ widely across cultures. Using census records and historical datasets, we present an information-theoretic analysis of name systems that shows how the scope of this variation is more constrained than it might appear. We identify two constraints name…
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Preoperative short physical performance battery in older adult patients with gastric cancer is associated with postoperative complications
BACKGROUND: Older adults with gastric cancer are at high risk of postoperative complications, partly owing to age-related physical function decline. The Short Physical Performance Battery (SPPB) is widely used to assess physical function in older adults; however, its association with postoperative…
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Cue-weighting in processing of prosodic boundaries in Dutch: An event-related potential (ERP) study
Across languages, major prosodic boundaries, such as intonational phrase (henceforth, IP) boundaries, are typically signalled via three types of prosodic cues, namely pitch change, final lengthening, and pause. However, the relative weight of each cue in the perception of IP boundaries differs…
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The impact of nerve management on the risk for persistent postoperative pain one year after open anterior mesh inguinal hernia repair
PURPOSE: Persistent postoperative pain is a major challenge in inguinal hernia surgery. However, the impact of intraoperative nerve management on postoperative pain is poorly understood. The aim was to evaluate how management of the three inguinal nerves during anterior mesh repair of inguinal…
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Hydrogen-rich saline treatment modulates proteomic profiles to mitigate cataract development in a N-methyl-N-nitrosourea-induced rat model
PURPOSE: Cataracts are associated with oxidative stress-induced damage to lens proteins. This study aims to identify differentially expressed proteins (DEPs) associated with the protective effects of hydrogen-rich saline (HRS) against N-methyl-N-nitrosourea (MNU)-induced cataracts, utilizing the…
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Translational and real-world evidence of trastuzumab biosimilar CT-P6 plus pertuzumab in neoadjuvant HER2-positive early breast cancer
BACKGROUND: Data on neoadjuvant treatment with trastuzumab biosimilars, particularly CT-P6, in combination with pertuzumab, are limited. This study evaluates the efficacy, tolerability, and immunogenicity of CT-P6 plus pertuzumab and chemotherapy, in routine clinical practice for HER2-positive…
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Induction chemotherapy with methotrexate, nimustine, and procarbazine for primary CNS lymphoma in the elderly: a retrospective evaluation of safety and efficacy
PURPOSE: Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extranodal non-Hodgkin lymphoma that predominantly affects elderly individuals. High-dose methotrexate (HD-MTX)-based chemotherapy remains the mainstay of PCNSL treatment, but the optimal combination regimen for…
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Real-world outcomes of reduced-dose versus standard-dose antibody drug conjugates in metastatic breast cancer: a retrospective cohort study
PURPOSE: To evaluate whether reduced doses (RD) of trastuzumab deruxtecan (T-DXd) or sacituzumab govitecan (SG) provide similar outcomes to the approved standard doses (SD) in metastatic breast cancer (mBC). METHODS: This retrospective cohort included mBC patients receiving at least one cycle of SG…
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Assessing the involvement of long-term memory in working memory
Complex span tasks are working memory (WM) tasks in which participants maintain series of items (e.g., letters) for further serial recall while performing a concurrent task (e.g., parity judgement on digits). It has been shown that even pushing the demand of this concurrent task at its individual…
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ViMDT: a clinical data visual analysis tool for multi-disciplinary treatment of lung cancer
Multi-disciplinary treatment (MDT) has become a routine practice in clinical cancer diagnosis and treatment, playing an indispensable role in clinical decision-making. By integrating expertise from multiple disciplines, MDT provides patients with individualized diagnosis and treatment strategies…
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Metabolic Alterations Induced by a Seizure-Causing Sodium Channel Mutation and their Partial Normalization by Dietary α-Linolenic Acid in Drosophila
Epilepsy is increasingly recognized as a disorder with prominent metabolic disturbances, but how defined epilepsy-causing mutations reshape metabolism under controlled genetic and environmental conditions remains poorly understood. Here, we used the Drosophila melanogaster gain-of-function…
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