11.943.971 hasil
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A comparative evaluation of salivary and serum procalcitonin to identify infants with serious bacterial infections
Differentiating serious bacterial infections (SBIs) from viral illnesses in infants remains challenging. Although serum procalcitonin (PCT) is a well-established biomarker, its measurement requires invasive blood sampling. This study investigated the correlation between salivary and serum PCT and…
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Asynchrony and functional diversity couple herbivore community dynamics to host plant diversity
Biodiversity loss can destabilize ecosystem functioning. How biodiversity–stability relationships are interlinked across trophic levels remains poorly investigated, however, limiting our ability to predict ecosystem-level consequences of declining biodiversity. Here, we analyze the drivers of…
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Uncertainty aware hybrid learning framework for fast and safe charging of lithium-ion batteries using multi-fidelity observers
Accurate and real-time estimation of the state of charge (SoC) is critical for ensuring the performance, safety, and longevity of lithium-ion batteries in electric vehicles (EVs). This research work presents an Uncertainty-Aware Hybrid Learning Framework for accurate and safe State-of-Charge (SoC)…
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Autonomic neural control of motor activity in the intestine of freshwater barramundi (Lates calcarifer)
Evolutionary pressure on the gastrointestinal (GI) tract of teleost fish differs substantially from those of terrestrial animals. The intestine is a pivotal organ in teleost, for maintaining osmotic balance against the surrounding aquatic environment; primarily through its role in water absorption…
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One-year consolidation with Ponatinib 15 mg in chronic myeloid leukaemia on deep molecular response with Imatinib
Tyrosine kinase inhibitors (TKIs) discontinuation is the standard option for patients with chronic myeloid leukaemia (CML) in deep molecular response (MR) with imatinib. This study aimed to evaluate the efficacy and safety of one year consolidation with ponatinib on treatment-free remission (TFR)…
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Imaging and fluid biomarkers for prognostic stratification in cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA) is a common small vessel disease characterized by Aβ deposition in cortical and leptomeningeal arteries, leading to lobar intracerebral hemorrhage and vascular cognitive impairment. Despite advances in diagnosis, prognosis remains highly heterogeneous, encompassing…
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Reliable directional relaying for T-Connected Series-Compensated transmission lines
This article introduces an extensive directional relaying algorithm designed for series-compensated transmission lines. The proposed algorithm relies on observing the locus of the calculated impedance of the change of the positive-sequence circuit. Both the voltage and current signals in positive…
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An experimental investigation of unique high stepup boost converter for electric vehicle and solar photovoltaic
High step-up DC–DC converters are essential in electric vehicle (EV) and photovoltaic (PV) applications, where low-voltage inputs must be efficiently boosted to higher levels. Conventional converters suffer from high switching losses, bulky components, and unstable regulation under dynamic…
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Risk of preterm birth and peripartal complications after first trimester termination of pregnancy: a retrospective cohort study of 35,897 singleton births
PURPOSE: The objective of this study was to explore whether a history of termination of pregnancy (TOP) in births after 2015 in a high income setting is still linked to preterm birth (PTB) and peripartal complications. METHODS: 35,897 singleton births from a perinatal center with approximately 5000…
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Candida Tropicalis Biofilm Formation Under Secondary Bile Salt Sodium Deoxycholate
Candida species are components of the normal intestinal microbiota and are under constant exposure to bacterial metabolites, including secondary bile salts. Secondary bile salts are produced by commensal bacteria in the intestine and not only affect lipid absorption through emulsification but also…
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Long-term transition of urinary status after robot-assisted radical prostatectomy
To clarify and statistically analyze the long-term transition of urinary condition and quality of life (QOL) after robot-assisted radical prostatectomy (RARP) using some self-report questionnaires. From May 2017 to June 2021, 243 patients who underwent RARP for prostate cancer at Chiba Tokushukai…
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Disproportionate increase of extreme obesity among older adults: an exploratory analysis from the English longitudinal study of ageing
BACKGROUND: The global rise in obesity increasingly includes extreme forms, notably BMI ≥ 50 kg/m², which present disproportionate health risks, especially among older adults. Despite this, most epidemiological research aggregates all obesity (BMI ≥ 30 kg/m²), potentially underestimating the burden…
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Patient-reported disease burden and health care utilization of HAE-nl-C1INH: insights from a real-world survey
Hereditary angioedema (HAE), a rare genetic disorder, is classified into 3 types: Type 1 (low C1 esterase inhibitor [C1-INH]), Type 2 (dysfunctional C1-INH), and HAE-nl-C1INH (normal C1-INH levels). This study aimed to compare characteristics among individuals with HAE Type 1/2 and HAE-nl-C1INH. A…
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Geographical traceability of bacteria based on a systematic stable isotope analysis method
ABSTRACT: The outbreak of certain bacteria can trigger severe diseases, even posing a threat to public safety, leading to significant social panic and economic losses. Thus, tracing the origin of bacteria is of great significance. Stable isotope analysis technology offers a new way to determine the…
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Mechanism of trans-envelope bacterial polysaccharide secretion in Class-3 outer-membrane polysaccharide export (OPX) protein systems
Bacterial secretion of extracellular polysaccharides is essential for surface colonization, biofilm formation, and pathogenesis. In diderm bacteria, such polymers traverse the periplasm and outer membrane (OM) through outer-membrane polysaccharide export (OPX) proteins that form secretion pores…
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Process and analytical strategies for the safe production of mRNA vaccines and therapeutics
The production of high-purity mRNA drug substances by in vitro transcription utilizing T7 RNA polymerase can be challenging due to the formation of product related impurities. These include double-stranded RNA, fragmented mRNA, and uncapped transcripts. This review examines the known mechanisms…
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Ultrasound-guided minimally invasive thoracotomy for removal of migrating grass Awn in a Cat
Migrating grass awns are a rare cause of thoracic reactions in cats, resulting in pleural effusion, inflammation, infection and granulomatous responses. Diagnosis and localization are challenging, and treatment commonly requires invasive surgical intervention. We report a case of a 5-year-old…
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Modeling truncated and censored data with the diffusion model in Stan
Reaction time data in psychology are frequently censored or truncated. For example, two-alternative forced-choice tasks that are implemented with a response window or response deadline give rise to censored or truncated data. This must be accounted for in the data analysis, as important…
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Prevalence, influencing factors, and dementia outcome of sarcopenic obesity in China
BACKGROUND: This study examines the epidemiology of sarcopenic obesity (SO) in China, focusing on national prevalence, modifiable influencing factors, and its longitudinal association with dementia risk in middle-aged and older adults. METHODS: Using the 2015 wave of the China Health and Retirement…
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Digital maternity care in Germany: a cross-sectional web-based survey on midwives’ perceptions
PURPOSE: Maternity care is a central component of any healthcare system and is largely provided by midwives. Considering increasing cost pressures and growing demand for efficiency within the German healthcare system, the development of efficient, digitally supported care models are both encouraged…
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