11.943.971 hasil
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Artikel Jurnal Teks lengkap
KIT Mutant/Core binding factor-negative acute myeloid leukemia might be a complex subgroup with dismal prognosis: a single-center retrospective analysis
KIT mutations are well-established as poor prognostic markers in core binding factor AML (CBF AML). However, data on KIT mutation in CBF-negative (CBF-neg) AML remains scarce. This retrospective study aimed to characterize the clinical features and outcomes of patients with KIT mutant (KIT…
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Effect of feeding mulberry leaves on nutrient digestibility, carcass characteristics, blood parameters and productive performance of growing Flanders rabbits
This study was conducted to evaluate the effect of mulberry leaves (ML) as an alternative source of clover hay on growth performance, nutrient digestibility, carcass traits, and blood parameters of Flanders rabbits. Thirty-six growing rabbits were randomly and equally divided to be fed three diets…
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Differentiable modelling and optimization of multi-planar slicing for multi-axis additive manufacturing
Multi-planar deposition, enabled by multi-axis additive manufacturing, provides an opportunity to address challenging issues in wire arc additive manufacturing, such as residual stresses and distortions. This strategy involves sequentially building sub-parts, by depositing material in each sub-part…
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Evaluation of agmatine’s anti-cancer efficacy in Caco-2 colorectal adenocarcinoma cells
This study aimed to evaluate the potential effects of agmatine on cell viability, migration, invasion, apoptosis, and the expression of the ABCB1, ABCC1, and ABCG2 genes in the Caco-2 colon cancer cell line. Agmatine efficacy was assessed thruogh proliferation, migration, and invasion assays at…
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Medical education and abortion care: evaluating an interdisciplinary learning module in Germany
BACKGROUND: In Germany, first-trimester abortions are legally restricted but allowed under certain conditions, including mandatory counseling and a reflection period. Accessibility concerns persist. To address gaps in medical training, we developed an interdisciplinary learning module on…
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Total plasma N-glycomic patterns of COVID-19 disease
Total plasma N-glycans alter in disease states, with few studies focused on COVID-19. A discovery cohort of 310 COVID-19 patients, replicated with 97 COVID-19 patients and tested with 100 COVID-19 patients, was used to unearth the N-glycans capable of distinguishing infection, as well as prognosis…
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Reduced Fascial Dehiscence with Combined Small-and-Large Technique Compared to Small-Bite Technique in Emergency Midline Laparotomy: A Retrospective Study
PURPOSE: This study aimed to compare the rates of fascial dehiscence after fascial closure using the combined small-and-large technique versus the small-bite technique following emergency laparotomy. METHODS: A retrospective, single-center, observational study was conducted. All patients who…
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Beyond bone effects: the role of denosumab in muscle Health – A systematic review
BACKGROUND: Denosumab, a monoclonal antibody targeting RANKL, is widely used for the treatment of osteoporosis. In addition to its skeletal benefits, emerging evidence suggests that denosumab may also exert positive effects on muscle health by modulating inflammation, myostatin expression, and…
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Association between systemic immune-inflammatory markers and monoclonal gammopathy of undetermined significance in the elderly population: findings from the National health and nutrition examination survey
BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma cell disorder whose prevalence increases with age and may progress to multiple myeloma. The tumor microenvironment plays a crucial role in MGUS pathogenesis and progression. Systemic immune-inflammatory…
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Age at diagnosis, lifestyle factors, and risk of mortality: a city-wide cohort study of cancer survivors
BACKGROUND: The growing global cancer burden highlights the urgent need to improve long-term outcomes among cancer survivors. Age-related biological changes may modify the associations between lifestyle factors and mortality, yet the joint effects of diagnostic age and lifestyle factors remain…
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TP53 mutation heterogeneity reveals distinct prognoses in mantle cell lymphoma
Mantle cell lymphoma (MCL) is an uncommon and aggressive type of B-cell non-Hodgkin lymphoma, wherein TP53 mutations play a critical role. This study analyzed the effect of different TP53 mutations on the clinical characteristics and prognosis of patients with MCL. TP53 sequencing data and clinical…
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Salivary proteomics of patients with type 2 diabetes identify potential biomarkers for diabetes and highlight significant role of immune response
Diabetes is a global public health problem, causing diverse complications, consequently compromising patient quality of life. Salivary proteome is affected by pathological conditions, however, the contributions of salivary proteins to diabetes are not fully understood. Hence, this study aimed to…
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Sugar- and artificially sweetened beverages consumption, body weight, and eating disorders symptoms: findings from a Danish cohort from childhood to early adulthood
PURPOSE: This study assessed the associations between the consumption of sugar- (SSBs) and artificially sweetened beverages (ASBs) and body weight from childhood through adolescence. Moreover, we examined the relationship between childhood weight status and the joint associations between SSBs and…
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The efficacy of reminiscence therapy on the cognition of older patients with cognitive impairment or dementia: a meta-analysis based on regulatory factors
BACKGROUND: With global aging, dementia prevalence is rising, imposing significant burdens. Reminiscence therapy (RT) shows promise for improving cognition in older adults with cognitive impairment or dementia, but evidence remains inconsistent, potentially moderated by factors like age…
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Social evaluation of skilfulness in Tonkean macaques (Macaca tonkeana) and brown capuchins (Sapajus apella)
For optimal decision-making, social animals can benefit from evaluating others’ behaviours. Some species seemingly consider the skills of others when deciding who to interact with in different contexts. Yet, whether and how nonhuman animals form impressions about others’ competence is still…
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Social and psychological effects of a stoma on the sexuality and self-image of patients
PURPOSE: Examining the psychosocial impact of stoma surgery on quality of life, sexual health, and body image, and analyzing demographic factors associated with these outcomes. METHODS: This cross-sectional study included 214 adults with a stoma. Validated instruments, the European Organization for…
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Fetal thoracoamniotic shunting for severe macrocystic congenital pulmonary airway malformation with the Somatex(®) intrauterine shunt: intrauterine course and postnatal outcome
PURPOSE: Thoracoamniotic shunting (TAS) in fetuses with macrocystic congenital pulmonary airway malformation (CPAM) is mostly performed with pigtail shunts like the rocket shunt or the Harrison fetal bladder stent. The aim of this study was to assess the prenatal course, perinatal outcome and…
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Pitching-specific facilitation of upper-limb corticospinal excitability during motor imagery of sports motor skills
Pitching is an essential skill in baseball, requiring precise and well-coordinated neural control. However, elucidating its underlying neural mechanisms remains challenging because of the methodological difficulties in assessing neural activity during dynamic movement. Motor imagery (MI) provides a…
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MYC-driven TRIM27 upregulation promotes prostate cancer progression by enhancing CANX ubiquitination and activating PI3K/AKT signaling
One of the most prevalent malignant tumors in the male genitourinary system is prostate cancer (PCa). The health of men is seriously threatened by the lack of appropriate treatment options for advanced prostate cancer. As E3 ubiquitin ligases, the TRIM family is essential for the development and…
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Priestia megaterium reduces hydrogen sulfide level in swine manure potentially through an assimilatory mechanism and microbiota modulation
ABSTRACT: Noxious odors from swine farms pose significant health and environmental concerns. Hydrogen sulfide (H(2)S) is one of the major compounds causing noxious odors. Using biological inoculants offers a promising, efficient, and cost-effective method to reduce H(2)S emissions from these farms…
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