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The journey to diagnosis and care of functional neurological disorder (FND)
Purpose: Functional neurological disorder (FND) is a common condition, associated with high disability and healthcare costs, and poor treatment access. This qualitative study aimed to explore participants’ experiences of being diagnosed with functional neurological disorder (FND), accessing…
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The role of SPP1 in evaluating the prognosis, immune infiltration, and drug sensitivity of hepatocellular carcinoma
Background: Secretory phosphoprotein 1 (SPP1) has been linked to tumor progression and immune regulation, but its prognostic value, impact on the tumor immune microenvironment (TIME), and drug sensitivity in HCC remain unclear. Methods: We performed a pan-cancer analysis using TIMER and validated…
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Forecasting under-five stunting in Ethiopia using classical and machine learning time series models
Background: The prevalence of under-five stunting in Ethiopia remains above 30%, which, according to World Health Organization (WHO), constitutes a major public health concern. Stunting has long-term consequences for child growth, development, and overall health. Accurate forecasting of its…
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In vivo mouse model of calcific myonecrosis induced by injury
Skeletal muscle is the major tissue that provides a space and source for bone, which is formed by osteoblasts through the secretion of extracellular matrices, such as type I collagen, and the deposition of hydroxyapatite calcium phosphate crystals. In the present study, we injected notexin, a snake…
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Effects of a joint outdoor exercise program for dog owners and dogs on physical activity, sedentary time and sleep-related behaviors
Lack of physical activity (PA) is a rising health challenge in both humans and companion dogs. Therefore, One Health strategies to increase PA in both species have been suggested. The aim of this pilot study was to evaluate the effects of a joint outdoor exercise program with jogging and circuit…
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The Cambridge Questionnaire for Apathy and Impulsivity Traits (CamQUAIT): a novel assessment tool for frontotemporal lobar degeneration-related syndromes
State of the Art: Apathy and impulsivity are common in syndromes associated with frontotemporal lobar degeneration (FTLD). They are associated with high carer distress and poor patient outcomes. There are limited treatment options and progress has been hindered by a lack of appropriate outcome…
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Evaluation of large language models in medical examinations: A scoping review protocol
Introduction: Standardized medical examinations, used to assess trainee clinical competencies, provide a rigorous means to verify LLM accuracy and reliability in medical contexts. Although current evaluations use these exams to test LLMs’ clinical reasoning, significant performance variations occur…
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Risk factors and outcomes of emerging Listeria monocytogenes infection in Pakistan: Insights from a tertiary care hospital
Background: Listeria monocytogenes is a Gram-positive rod responsible for listeriosis. It has emerged as a significant foodborne pathogen and has been implicated in numerous outbreaks worldwide often present with bacteremia and may progress to severe manifestations such as meningoencephalitis…
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Contextualizing cannabis water demand and potential for streamflow impacts relative to residential and agricultural users in Northern California
This study examines the relative water demand and potential streamflow impacts of cannabis cultivation, residential use, and non-cannabis agriculture in rural northern California watersheds. While cannabis has received much attention for its potential impact on sensitive aquatic species, the…
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Unraveling the Cretaceous-Paleogene boundary event across the Gulf of Mexico—High-resolution Rayon reef section, Valles-San Luis Potosi platform, Mexico
The Cretaceous/Paleogene boundary, marked by the Chicxulub impact ejecta layer has a global distribution, with distal, intermediate and proximal boundary sections of distinct mineralogy, geochemistry and stratigraphy. Distal sections show a thin double-layer of spherulites and clay, enriched in…
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A cross-sectional study on the impact of early systematic antidepressant therapy on positive/negative affect and impulsivity in euthymic bipolar disorder patients
Background and objectives: Due to an initial misdiagnosis, bipolar patients who experienced a depressive episode as their first onset were often treated with antidepressants, and continued to exhibit sleep disturbances and elevated impulsivity, even during periods of euthymia. The study aims to…
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Antitumoral immunity induced by gel ethanol ablation to treat unresectable colorectal cancer metastases in the liver
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. A quarter of CRC patients develop liver metastases. Treatment options for liver metastases include surgically removing the tumors or undergoing liver transplantation; however, many patients are ineligible for…
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RMETNet: A cross-subject motor imagery EEG signal classification model based on TSLANet and riemannian geometry features
Motor imagery electroencephalogram (MI-EEG) analysis is essential for natural interaction and autonomous control in brain-computer interfaces (BCIs). However, deep learning models often struggle with inter-subject variability, which limits their ability to generalize across subjects. This study…
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Tracking tuberculosis control using detailed population health and satellite luminosity data: findings from Kazakhstan
Following the collapse of the Soviet Union, Kazakhstan, like many other formerly socialist countries, experienced a surge in tuberculosis (TB). Despite the successful efforts of Kazakhstan’s Ministry of Health in reducing TB related mortality, analysis of TB risk factors in Kazakhstan remains…
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Cryptic diversity in Astroblepus (Siluriformes: Astroblepidae): Integrative taxonomy reveals evolutionary complexity in the Esmeraldas River Basin, Ecuador
Astroblepus is a genus of endemic Andean catfishes with problematic taxonomy because of cryptic diversity, ambiguous historical descriptions, and morphological plasticity. This study applied an integrative taxonomy approach—combining DNA barcoding (COI gene), geometric morphometrics, and…
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EconoGNN: A graph neural network framework for temporal economic resilience insights
Global economic shocks such as the 2008 financial crisis or recent trade escalations between the United States and China have exposed the complexity of interdependent economies and the need for systemic, multi-agent analysis. However, most regional economic resilience (RER) studies remain limited…
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Attenuation of higher-order acoustic modes in a cylindrical waveguide using lined panel-cavity coupling
This work presents a mode-matching framework for analyzing acoustic attenuation in a waveguide that incorporates a centrally lined chamber, membrane discs at the interfaces, and extended inlet–outlet sections. The formulation also covers configurations with a lined cavity backed by rigid or soft…
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A flow cytometric assay of murine erythrocyte osmotic fragility
Flow cytometric test of erythrocyte osmotic fragility (EOF) is a critical diagnostic tool for evaluating membrane stability in hemolytic disorders and storage lesions of human erythrocytes. However, there is a lack of such protocols tailored for mice, one of the most widely used preclinical animal…
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