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Artikel Jurnal Teks lengkap
PLoS Computational Biology Issue Image | Vol. 2(11) November 2006
Colony of differentiated embryonic stem cells: The loss of critical stem cell properties can be detected through specific gene expression changes. In Glover et al, these changes were identified by meta-analysis of multiple, disparate datasets using Pareto front analysis. In the background is an…
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PLoS Genetics Issue Image | Vol. 2(11) November 2006
Projections of hexamer sequence space in the vicinity of the sequences GAAGAA and TATATT: Neighboring sequences are predictive of splicing regulatory element activity. Shown here are projections of hexamer sequence space in the vicinity of the sequences GAAGAA (left blue circle) and TATATT (right…
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Artikel Jurnal Teks lengkap
PLoS Pathogens Issue Image | Vol. 2(11) November 2006
Systemic acquired resistence in wild type Arabidopsis: Transcriptional reprogramming characterizes systemic acquired resistance in wild-type Arabidopsis plants. Upregulated genes are shown in red and downregulated genes in green. This reprogramming is dramatically blocked in the npr1 mutant…
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Selection of Target Sites for Mobile DNA Integration in the Human Genome
DNA sequences from retroviruses, retrotransposons, DNA transposons, and parvoviruses can all become integrated into the human genome. Accumulation of such sequences accounts for at least 40% of our genome today. These integrating elements are also of interest as gene-delivery vectors for human gene…
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Artikel Jurnal Teks lengkap
Computational Inference of Neural Information Flow Networks
Determining how information flows along anatomical brain pathways is a fundamental requirement for understanding how animals perceive their environments, learn, and behave. Attempts to reveal such neural information flow have been made using linear computational methods, but neural interactions are…
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Meta-Analysis of Differentiating Mouse Embryonic Stem Cell Gene Expression Kinetics Reveals Early Change of a Small Gene Set
Stem cell differentiation involves critical changes in gene expression. Identification of these should provide endpoints useful for optimizing stem cell propagation as well as potential clues about mechanisms governing stem cell maintenance. Here we describe the results of a new meta-analysis…
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Robustness and Fragility in Immunosenescence
We construct a model to study tradeoffs associated with aging in the adaptive immune system, focusing on cumulative effects of replacing naive cells with memory cells. Binding affinities are characterized by a stochastic shape space model. System loss arising from an individual infection is…
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Alternative Splicing at NAGNAG Acceptors: Simply Noise or Noise and More?
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Artikel Jurnal Teks lengkap
Genomic Imprinting in Mammals: Emerging Themes and Established Theories
The epigenetic events that occur during the development of the mammalian embryo are essential for correct gene expression and cell-lineage determination. Imprinted genes are expressed from only one parental allele due to differential epigenetic marks that are established during gametogenesis…
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Pigment Pattern in jaguar/obelix Zebrafish Is Caused by a Kir7.1 Mutation: Implications for the Regulation of Melanosome Movement
Many animals have a variety of pigment patterns, even within a species, and these patterns may be one of the driving forces of speciation. Recent molecular genetic studies on zebrafish have revealed that interaction among pigment cells plays a key role in pattern formation, but the mechanism of…
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Operon Conservation and the Evolution of trans -Splicing in the Phylum Nematoda
The nematode Caenorhabditis elegans is unique among model animals in that many of its genes are cotranscribed as polycistronic pre-mRNAs from operons. The mechanism by which these operonic transcripts are resolved into mature mRNAs includes trans-splicing to a family of SL2-like spliced leader…
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Correction: Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells
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Artikel Jurnal Teks lengkap
Opposite Root Growth Phenotypes of hy5 versus hy5 hyh Mutants Correlate with Increased Constitutive Auxin Signaling
The Arabidopsis transcription factor HY5 controls light-induced gene expression downstream of photoreceptors and plays an important role in the switch of seedling shoots from dark-adapted to light-adapted development. In addition, HY5 has been implicated in plant hormone signaling, accounting for…
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Inference of Splicing Regulatory Activities by Sequence Neighborhood Analysis
Sequence-specific recognition of nucleic-acid motifs is critical to many cellular processes. We have developed a new and general method called Neighborhood Inference (NI) that predicts sequences with activity in regulating a biochemical process based on the local density of known sites in sequence…
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Temporal Analysis of Meiotic DNA Double-Strand Break Formation and Repair in Drosophila Females
Using an antibody against the phosphorylated form of His2Av (γ-His2Av), we have described the time course for the series of events leading from the formation of a double-strand break (DSB) to a crossover in Drosophila female meiotic prophase. MEI-P22 is required for DSB formation and localizes to…
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Impact of Nonsense-Mediated mRNA Decay on the Global Expression Profile of Budding Yeast
Nonsense-mediated mRNA decay (NMD) is a eukaryotic mechanism of RNA surveillance that selectively eliminates aberrant transcripts coding for potentially deleterious proteins. NMD also functions in the normal repertoire of gene expression. In Saccharomyces cerevisiae, hundreds of endogenous RNA…
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Genomic Selective Constraints in Murid Noncoding DNA
Recent work has suggested that there are many more selectively constrained, functional noncoding than coding sites in mammalian genomes. However, little is known about how selective constraint varies amongst different classes of noncoding DNA. We estimated the magnitude of selective constraint on a…
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Artikel Jurnal Teks lengkap
Safety and Reactogenicity of an MSP-1 Malaria Vaccine Candidate: A Randomized Phase Ib Dose-Escalation Trial in Kenyan Children
Objective: : Our aim was to evaluate the safety, reactogenicity, and immunogenicity of an investigational malaria vaccine. Design: : This was an age-stratified phase Ib, double-blind, randomized, controlled, dose-escalation trial. Children were recruited into one of three cohorts (dosage groups)…
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