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Artikel Jurnal Teks lengkap
Telomere Crisis Shapes Cancer Evolution
Somatic mutations arise in normal tissues and precursor lesions, often targeting cancer-driver genes involved in cell cycle regulation. Most checkpoint-mutant clones, however, remain dormant throughout an individual’s lifetime and seldom progress to malignancy, implying the presence of protective…
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Bayesian Temporal Prediction: A Robust Algorithm for Real-time EEG Phase-dependent Brain Stimulation
OBJECTIVE: Real-time estimation of brain state is essential for efficient brain stimulation. Specifically, the electroencephalography (EEG) oscillation phase arose as a promising biomarker for instantaneous brain excitability, making it ideal for state-dependent brain stimulation. Current methods…
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Unravelling Sleep Apnea Dynamics: Quantifying Loop Gain using Dynamical Modelling of Ventilatory Control
STUDY OBJECTIVES: Loop gain (LG) is a critical parameter for assessing ventilatory control stability in sleep apnea, with implications for personalized treatment. Existing LG estimation methods are hindered by complex processing and specialized equipment, limiting clinical applicability. This study…
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Prevalence of Chlamydial, Gonococcal, and Syphilis Positivity by Anatomical Site and Sex Via Self-Collected Biospecimens Using At-Home Testing Kits Among a Large and Diverse Cohort of Men and Women Enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) in the United States
INTRODUCTION. Cisgender men who have sex with men (MSM), transgender women, cisgender women, and cisgender men who have sex with women only (MSW) have differential risk of acquiring Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC), the two most commonly reported bacterial sexually…
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Approaches to the Management of Virologic Failure on Dolutegravir-Based Antiretroviral Therapy in the 50 Countries with the Highest Adult HIV Prevalence
Expanded access to dolutegravir as part of a fixed-dose combination with tenofovir disoproxil fumarate and lamivudine (TLD) has revolutionized global HIV treatment, with more than 25 million people prescribed this regimen in 2024. We reviewed national clinical guidelines for management of virologic…
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Childhood Cancer Data Initiative: Expanded access to tumor molecular profiling for children, adolescents, and young adults
The Molecular Characterization Initiative (MCI), a key effort of the NCI’s Childhood Cancer Data Initiative (CCDI), was launched in 2022 in collaboration with the Children’s Oncology Group (COG) to bring comprehensive genomic and molecular profiling to children, adolescents and young adults…
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Parvalbumin interneurons mediate sex differences in prefrontal cortex function
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Artikel Jurnal Teks lengkap
Clinical Measurement of Transepidermal Water Loss
SIGNIFICANCE: Recent reports recognize transepidermal water loss (TEWL) as a critical objective parameter measuring clinical wound healing endpoint. At the site of wound repair, TEWL measures functional wound closure as marked by re-establishment of barrier function at the wound site. This review…
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Reported Neurologic Manifestations Among Persons With Syphilis by Stage of Infection—12 States, 2019–2022
National case-based surveillance data show that reported neurologic manifestations of syphilis increased during 2019–2022 among persons with early and late-stage syphilis. Neurologic manifestations occurred across demographic groups and among those with and without human immunodeficiency virus…
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The Role of Biliverdin Reductase, a Heme Degradation Pathway Enzyme, in the Development of Vasospasm after Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a life-threatening condition with high mortality and significant neurological morbidity, often complicated by delayed cerebral ischemia (DCI) and vasospasm. Heme metabolites, such as biliverdin (BV), are implicated in SAH-induced vascular dysfunction, yet the role…
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Digital credentials for environmental competencies: A scoping review of open recognition systems in climate education
Open education recognition systems are transforming how skills and competencies are validated across formal, informal, and non-formal learning environments. This scoping review examines current practices in open recognition systems—including micro-credentials, digital badges, and open educational…
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High rates of post tuberculosis lung disease among persons successfully treated for drug susceptible and resistant tuberculosis
INTRODUCTION: Tuberculosis remains a critical global public health challenge and there is an urgent need to improve the diagnosis and management of post-tuberculosis lung disease (PTLD). We aimed to compare end of treatment prevalence of PTLD among participants with and without drug-resistant…
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Balanced steady state free precession enables high-resolution dynamic 3D Deuterium Metabolic Imaging of the human brain at 7T
OBJECTIVES: Deuterium ((2)H) Metabolic Imaging (DMI) is an emerging magnetic resonance technique to non-invasively map human brain glucose (Glc) uptake and downstream metabolism following oral or intravenous administration of (2)H-labeled Glc. The achievable spatial resolution is limited due to…
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Marketing for Sensa: a ‘zero nicotine vapor product’ from a major tobacco company
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Artikel Jurnal Teks lengkap
Multimodal imaging demonstrates anti-fibrotic effects of targeting α(v)β(6)/α(v)β(1) integrins in biliary fibrosis
OBJECTIVES: Development of molecular therapies for liver fibrosis are slowed by a lack of non-invasive methods addressing questions of target expression, target engagement, and treatment response. Integrin α(v)β(6) is a biomarker of liver fibrosis that is upregulated in livers of patients with…
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Artikel Jurnal Teks lengkap
Are We Ready for AI-Augmented Generalists?
Artificial Intelligence (AI) is reshaping medical practice and education by unifying the knowledge of medical specialties and subspecialties into a single, intelligent system. This system functions not only as an integrated knowledge base but also as an active cognitive collaborator. By bridging…
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Comparative Safety of Different Antibiotic Regimens for the Treatment of Outpatient Community-Acquired Pneumonia Among Otherwise Healthy Adults
BACKGROUND. Evidence is limited on the comparative safety of antibiotic regimens for treatment of community-acquired pneumonia (CAP). We compared the risk of adverse drug events (ADEs) associated with antibiotic regimens for CAP treatment among otherwise healthy, nonelderly adults. METHODS. We…
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Minimally-Invasive Overactive Bladder Therapy after Prolapse Surgery
IMPORTANCE: Associations between pelvic organ prolapse and overactive bladder exist, yet little is known regarding minimally-invasive overactive bladder therapy use among older women following prolapse surgery. OBJECTIVE: Determine minimally-invasive overactive bladder therapy use…
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Artikel Jurnal Teks lengkap
GLAPAL-H: Global, Local, And Parts Aware Learner for Hydrocephalus Infection Diagnosis in Low-Field MRI
OBJECTIVE: The study aims to develop a method for differentiating between healthy, post-infectious hydrocephalus (PIH), and non-post-infectious hydrocephalus (NPIH) in infants using low-field MRI, which is a safer, low-cost alternative to CT scans. The study develops a custom approach that captures…
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