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Artikel Jurnal Teks lengkap
Neuroprotective effects of traditional Chinese medicine formulas in animal models of retinal degenerative diseases: a systematic review and meta-analysis
PURPOSE: Retinal degenerative diseases (RDDs) cause irreversible vision loss with limited treatment options. Traditional Chinese medicine (TCM) formulas have demonstrated neuroprotective effects, yet their overall efficacy lacks comprehensive meta-evidence. The aim of this study was to…
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The effectiveness of social support interventions on loneliness among older people in the community: a meta-analysis of randomised controlled trials
BACKGROUND: To combat loneliness among elderly individuals, it is crucial to identify effective strategies that can alleviate the negative impact of loneliness on their overall well-being. OBJECTIVE: This study evaluated social support programs’ impact on loneliness in community-dwelling older…
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Meta-analysis of the effects of probiotic supplementation on bone turnover markers in middle-aged and elderly patients with osteoporosis
BACKGROUND: Osteoporosis is highly prevalent among postmenopausal women and is characterized by a progressive 1–2% annual decline in bone mineral density (BMD). This deterioration contributes to more than 8.9 million fractures globally each year. The condition arises from an imbalance between bone…
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Precision dentistry in preclinical education: analytic rubrics for enhanced objectivity in metal-ceramic crown preparations
INTRODUCTION: Preclinical dental training requires students to master precise tooth preparation skills that directly influence clinical success. Traditional grading methods often lack objectivity and consistency. Analytic rubrics, by deconstructing complex procedures into measurable components, may…
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Enzymatic and microenvironmental regulation in adenosine metabolism-mediated immunosuppression
Adenosine (ADO), as an endogenous purine nucleoside, can regulate almost all aspects of tissue function. However, its abnormal accumulation in the tumor microenvironment (TME) induces immune tolerance and promotes tumor immune evasion by activating adenosine receptors (ADOR). Regulating ADO…
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Artikel Jurnal Teks lengkap
Soil nifH-harboring community assemblage varies across pecan cultivars
INTRODUCTION: This study focused on three pecan (Carya illinoinensis) cultivars (‘Pawnee’, ‘Mahan’, and ‘Jinhua’), systematically assessing variations in soil nitrogenase activity, characteristics traits of nifH-harboring microbial communities across these cultivars. METHODS: Using high-throughput…
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Epidemiologic characteristics and clinical outcomes of respiratory syncytial virus in hospitalized care in Lebanon: a prospective observational study
INTRODUCTION: The aim of this study was to describe the epidemiology and clinical outcomes of respiratory syncytial virus (RSV) infection in hospitalized children and adults from a sentinel surveillance network in Lebanon, and to compare the RSV rates and seasonality before and during COVID-19…
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Artikel Jurnal Teks lengkap
Perioperative anesthesia management of high-molecular-weight kininogen deficiency: a case report and literature review
A prolonged activated partial thromboplastin time (APTT) is a common abnormal finding in preoperative coagulation screening. Failure to accurately identify its underlying etiology can lead to a misjudgment of bleeding risk, potentially resulting in surgical delays, unnecessary transfusion of blood…
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Artikel Jurnal Teks lengkap
Rapid and visual detection of Tacheng tick virus 1 using loop-mediated isothermal amplification technique
INTRODUCTION: Tacheng tick virus 1 (TcTV-1) is an emerging tick-borne nairovirus associated with human febrile illness. To date, no reliable detection method for TcTV-1 has been established. In this study, we developed and evaluated a rapid loop-mediated isothermal amplification (LAMP) assay for…
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Artikel Jurnal Teks lengkap
Multi-level determinants of physical activity and sports participation among adults during COVID-19 pandemic: an interpretable machine learning approach
BACKGROUND: Both physical activity (PA) and sports participation (SP) are considered important for the promotion of health among adults in the post-disease outbreak period. In the context of the COVID-19 pandemic, the study applied the Socio-ecological Model, with a total of 45 factors on four…
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Artikel Jurnal Teks lengkap
Disrupted gray matter structural covariance networks in chronic insomnia disorder
BACKGROUND: Chronic insomnia disorder (CID) is associated with changes in gray matter volume (GMV) and structural connectivity in several brain regions. However, alterations in the topological properties of the structural covariant network (SCN) remain poorly understood in CID. METHODS: Voxel-based…
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Lactobacillus gasseri CBT LGA2 alleviates muscle protein degradation and inflammation in immobilization-induced mouse
INTRODUCTION: Hindlimb immobilization rapidly induces skeletal muscle atrophy by reducing mechanical loading and accelerating proteolytic activity. This atrophy is further exacerbated by inflammatory signaling, which amplifies FOXO3a-driven expression of Atrogin-1 and MuRF1 and suppresses myogenic…
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Multi-modal AI in precision medicine: integrating genomics, imaging, and EHR data for clinical insights
Precision healthcare is increasingly oriented toward the development of therapeutic strategies that are as individualized as the patients receiving them. Central to this paradigm shift is artificial intelligence (AI)-enabled multi-modal data integration, which consolidates heterogeneous data…
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Mitochondrial dysfunction and apoptotic signaling induced by the combined action of 2-aminoethyl dihydrogen phosphate and methyl-β-cyclodextrin in melanoma cells
Melanoma cells exhibit remarkable metabolic adaptability, sustained by lipid enrichment and mitochondrial resilience that enable survival under stress. Disrupting these bioenergetic and structural supports may represent an effective therapeutic avenue. This study investigated the antiproliferative…
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DDI-AttendNet: cross attention with structured graph learning for inter-drug connectivity analysis
INTRODUCTION: In the context of interdisciplinary computational science and its increasingly vital role in advancing applied computer-aided drug discovery, the accurate characterization of inter‐drug connectivity is essential for identifying synergistic therapeutic effects, mitigating adverse…
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Artikel Jurnal Teks lengkap
An adaptive fusion of composite attention convolutional neural network for polyp image segmentation
BACKGROUND: Accurate localization and segmentation of polyp lesions in colonoscopic images are crucial for the early diagnosis of colorectal cancer and treatment planning. However, endoscopic imaging is often affected by noise interference. This includes issues like uneven illumination, mucosal…
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Artikel Jurnal Teks lengkap
Emotional regulation and mental health profiles among Chinese junior middle school students: evidence for the dual-factor model
OBJECTIVE: This study explored latent mental health profiles among adolescents in southwestern China and the association with emotional regulation using the dual-factor model framework. METHODS: 1,682 junior middle school students completed the Emotion Regulation Questionnaire (ERQ), Center for…
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Factors influencing chronic disease self-management behaviors: a national multilevel analysis in China
OBJECTIVE: This study employed multilevel analysis to examine the impact of the prefecture-level city level variable (number of physicians per 1,000 population) on chronic disease self-management behavior (CDSMB) among Chinese adults, while also investigating the effects of individual-level control…
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Artikel Jurnal Teks lengkap
Efficacy of psychosensory interventions for the management of pediatric pain, fear, and distress during emergency care: a systematic review and meta-analysis of randomized clinical trials
The experience of invasive medical procedures (IMP) in pediatric emergency departments (PEDs) is often highly stressful for children and adolescents and potentially leads to short- and long-term biopsychosocial consequences. To address these challenges, psychological and sensory strategies have…
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Artikel Jurnal Teks lengkap
The cGAS-STING signaling pathway: emerging targets and challenges in breast cancer immunotherapy
The cGAS-STING signaling pathway serves as a crucial bridge between innate and adaptive immunity, playing a dual role in breast cancer pathogenesis and treatment. This review delves into its complex functions within the breast tumor microenvironment, where pathway activation can either stimulate…
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